日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis prevention

对人类造血干细胞进行表观基因组编辑可实现持续且可逆的血栓预防。

Ye, Tianyi; Xu, Wanying; Barrachina, Maria N; Lyu, Peng; Antoszewski, Mateusz; Volpe, Lucrezia Della; Guo, Chun-Jie; Lee, Andrew J; Theardy, Madelaine S; Shelton, Spencer D; Wahlster, Lara; Caulier, Alexis; Messa, Luana; Poeschla, Michael; Agarwal, Gaurav; Mitra, Ronodeep; Schmaier, Alec A; Weissman, Jonathan S; Machlus, Kellie R; Sankaran, Vijay G

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

MECOM对CEBPA的抑制作用会阻断分化,从而驱动侵袭性白血病的发生。

Fleming, Travis J; Antoszewski, Mateusz; Lambo, Sander; Gundry, Michael C; Piussi, Riccardo; Wahlster, Lara; Shah, Sanjana; Reed, Fiona E; Dong, Kevin D; Paulo, Joao A; Gygi, Steven P; Mimoso, Claudia; Goldman, Seth R; Adelman, Karen; Perry, Jennifer A; Pikman, Yana; Stegmaier, Kimberly; Barrachina, Maria N; Machlus, Kellie R; Hovestadt, Volker; Arruda, Andrea; Minden, Mark D; Voit, Richard A; Sankaran, Vijay G

A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan.

小鼠的类似蛰伏的状态会减缓血液表观遗传衰老,延长健康寿命

Jayne Lorna, Lavin-Peter Aurora, Roessler Julian, Tyshkovskiy Alexander, Antoszewski Mateusz, Ren Erika, Markovski Aleksandar, Sun Senmiao, Yao Hanqi, Sankaran Vijay G, Gladyshev Vadim N, Brooke Robert T, Horvath Steve, Griffith Eric C, Hrvatin Sinisa

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells.

基因变异揭示了一种同源异型长链非编码RNA,该RNA能够调节人类造血干细胞

Lyu Peng, Agarwal Gaurav, Guo Chun-Jie, Ye Tianyi, Weng Chen, Antoszewski Mateusz, Joubran Samantha, Caulier Alexis, Poeschla Michael, Sankaran Vijay G

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

通过改变干细胞 RNA 调控来获得对克隆造血的遗传抵抗力

Agarwal Gaurav, Antoszewski Mateusz, Xie Xueqin, Pershad Yash, Arora Uma P, Poon Chi-Lam, Lyu Peng, Lee Andrew J, Guo Chun-Jie, Ye Tianyi, Norford Laila Barakat, Neehus Anna-Lena, Volpe Lucrezia Della, Wahlster Lara, Ranasinghe Diyanath, Ho Tzu-Chieh, Barlowe Trevor S, Chow Arthur, Schurer Alexandra, Taggart James, Durham Benjamin H, Abdel-Wahab Omar, McGraw Kathy L, Allan James M, Soldatov Ruslan, Bick Alexander G, Kharas Michael G, Sankaran Vijay G

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

MECOM对CEBPA的抑制作用会阻断分化,从而驱动侵袭性白血病的发生。

Fleming, Travis J; Antoszewski, Mateusz; Lambo, Sander; Gundry, Michael C; Piussi, Riccardo; Wahlster, Lara; Shah, Sanjana; Reed, Fiona E; Dong, Kevin D; Paulo, Joao A; Gygi, Steven P; Mimoso, Claudia; Goldman, Seth R; Adelman, Karen; Perry, Jennifer A; Pikman, Yana; Stegmaier, Kimberly; Barrachina, Maria N; Machlus, Kellie R; Hovestadt, Volker; Arruda, Andrea; Minden, Mark D; Voit, Richard A; Sankaran, Vijay G

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Tcf1对于T细胞急性淋巴细胞白血病(T-ALL)中致癌性Notch1驱动的染色质拓扑结构的启动至关重要。

Antoszewski, Mateusz; Fournier, Nadine; Ruiz Buendía, Gustavo A; Lourenco, Joao; Liu, Yuanlong; Sugrue, Tara; Dubey, Christelle; Nkosi, Marianne; Pritchard, Colin E J; Huijbers, Ivo J; Segat, Gabriela C; Alonso-Moreno, Sandra; Serracanta, Elisabeth; Belver, Laura; Ferrando, Adolfo A; Ciriello, Giovanni; Weng, Andrew P; Koch, Ute; Radtke, Freddy