日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Alpha-B-Crystallin 过表达足以促进小鼠的肿瘤发生和转移

Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M Apaja, Pascal H G Duijf, John Finnie, Kum Kum Khanna

Addressing Dynamics at Catalytic Heterogeneous Interfaces with DFT-MD: Anomalous Temperature Distributions from Commonly Used Thermostats

利用DFT-MD方法研究催化异相界面动力学:常用恒温器中的异常温度分布

Korpelin, Ville; Kiljunen, Toni; Melander, Marko M; Caro, Miguel A; Kristoffersen, Henrik H; Mammen, Nisha; Apaja, Vesa; Honkala, Karoliina

Reprogramming endo-lysosomal proteostasis disease stress by UBR1- and arginylation-driven endophagy and autophagy protein quality control

UBR1和精氨酸化驱动的内吞作用和自噬作用对内溶酶体蛋白稳态疾病应激的重编程蛋白质质量控制

Wang, Ben B; Apaja, Pirjo M

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes

Endofin 是 HD-PTP 和 ESCRT-0 相互依赖的内体泛素化跨膜货物分选所必需的

Jalal M Kazan, Guillaume Desrochers, Claire E Martin, Hyeonju Jeong, Dmitri Kharitidi, Pirjo M Apaja, Ariel Roldan, Nicole St Denis, Anne-Claude Gingras, Gergely L Lukacs, Arnim Pause

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase

RFFL E3 连接酶对 CFTR 进行不依赖伴侣的外周质量控制

Tsukasa Okiyoneda, Guido Veit, Ryohei Sakai, Misaki Aki, Takeshi Fujihara, Momoko Higashi, Seiko Susuki-Miyata, Masanori Miyata, Norihito Fukuda, Akihiko Yoshida, Haijin Xu, Pirjo M Apaja, Gergely L Lukacs

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

分子伴侣在单分子和细胞中拯救突变 CFTR 的能量格局

Miklos Bagdany, Guido Veit, Ryosuke Fukuda, Radu G Avramescu, Tsukasa Okiyoneda, Imad Baaklini, Jay Singh, Guy Sovak, Haijin Xu, Pirjo M Apaja, Sara Sattin, Lenore K Beitel, Ariel Roldan, Giorgio Colombo, William Balch, Jason C Young, Gergely L Lukacs

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking

导致白质脑病的 CLCN2 突变与 Cl- 通道功能和运输受损有关

Héctor Gaitán-Peñas, Pirjo M Apaja, Tanit Arnedo, Aida Castellanos, Xabier Elorza-Vidal, David Soto, Xavier Gasull, Gergely L Lukacs, Raúl Estévez

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

核糖体柄蛋白沉默部分纠正了 ΔF508-CFTR 功能表达缺陷

Guido Veit, Kathryn Oliver, Pirjo M Apaja, Doranda Perdomo, Aurélien Bidaud-Meynard, Sheng-Ting Lin, Jingyu Guo, Mert Icyuz, Eric J Sorscher, John L Hartman IV, Gergely L Lukacs

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

内体 pH 和配体占据在整合素 α5β1 泛素化、内吞分选和细胞迁移中的相互作用

Dmitri Kharitidi, Pirjo M Apaja, Sanaz Manteghi, Kei Suzuki, Elena Malitskaya, Ariel Roldan, Marie-Claude Gingras, Junichi Takagi, Gergely L Lukacs, Arnim Pause

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

一些门控增强剂,包括 VX-770,会降低 ΔF508-CFTR 的功能表达。

Veit, Guido; Avramescu, Radu G; Perdomo, Doranda; Phuan, Puay-Wah; Bagdany, Miklos; Apaja, Pirjo M; Borot, Florence; Szollosi, Daniel; Wu, Yu-Sheng; Finkbeiner, Walter E; Hegedus, Tamas; Verkman, Alan S; Lukacs, Gergely L