日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

C1Q(+) TPP1(+) macrophages promote colon cancer progression through SETD8-driven p53 methylation.

C1Q(+) TPP1(+) 巨噬细胞通过 SETD8 驱动的 p53 甲基化促进结肠癌进展

Veschi Veronica, Verona Francesco, Di Bella Sebastiano, Turdo Alice, Gaggianesi Miriam, Di Franco Simone, Mangiapane Laura Rosa, Modica Chiara, Lo Iacono Melania, Bianca Paola, Brancato Ornella Roberta, D'Accardo Caterina, Porcelli Gaetana, Lentini Vincenzo Luca, Sperduti Isabella, Sciacca Elisabetta, Fitzgerald Peter, Lopez-Perez David, Martine Pierre, Brown Kate, Giannini Giuseppe, Appella Ettore, Stassi Giorgio, Todaro Matilde

SGSS05-NS3, a covalent SETD8 inhibitor that activates p53 pathway in neuroblastoma

SGSS05-NS3 是一种共价 SETD8 抑制剂,可激活神经母细胞瘤中的 p53 通路。

Liu, Zhihui; Bagchi, Sukriti; Yan, Chunhua; Hu, Ying; Blum, Gil; Ma, Anqi; Jin, Jian; Luo, Minkui; Di Bella, Sebastiano; Verona, Francesco; Appella, Ettore; Giannini, Giuseppe; Thiele, Carol J; Veschi, Veronica

Publisher Correction: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques

出版商更正:疫苗加杀微生物剂可有效预防猕猴阴道内SIV病毒的传播

Rahman, Mohammad Arif; Bissa, Massimiliano; Silva de Castro, Isabela; Helmold Hait, Sabrina; Stamos, James D; Bhuyan, Farzana; Hunegnaw, Ruth; Sarkis, Sarkis; Gutowska, Anna; Doster, Melvin N; Moles, Ramona; Hoang, Tanya; Miller Jenkins, Lisa M; Appella, Ettore; Venzon, David J; Choo-Wosoba, Hyoyoung; Cardozo, Timothy; Baum, Marc M; Appella, Daniel H; Robert-Guroff, Marjorie; Franchini, Genoveffa

The p53 Saga: Early Steps in the Development of Tumor Immunotherapy

p53传奇:肿瘤免疫疗法发展的早期步骤

DeLeo, Albert B; Appella, Ettore

A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity

捕获的人类PPM1A-磷酸肽复合物揭示了对PPM蛋白磷酸酶活性调控至关重要的结构特征

Debnath, Subrata; Kosek, Dalibor; Tagad, Harichandra D; Durell, Stewart R; Appella, Daniel H; Acevedo, Roderico; Grishaev, Alexander; Dyda, Fred; Appella, Ettore; Mazur, Sharlyn J

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

表观遗传siRNA和化学筛选发现SETD8抑制是治疗高危神经母细胞瘤中p53激活的有效策略

Veschi, Veronica; Liu, Zhihui; Voss, Ty C; Ozbun, Laurent; Gryder, Berkley; Yan, Chunhua; Hu, Ying; Ma, Anqi; Jin, Jian; Mazur, Sharlyn J; Lam, Norris; Souza, Barbara K; Giannini, Giuseppe; Hager, Gordon L; Arrowsmith, Cheryl H; Khan, Javed; Appella, Ettore; Thiele, Carol J

A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins

一种预防HIV-1感染的新型策略:联合使用靶向核衣壳蛋白和融合蛋白的抑制剂

Yang, Yu; Zhu, Jingyu; Hassink, Matthew; Jenkins, Lisa M Miller; Wan, Yanmin; Appella, Daniel H; Xu, Jianqing; Appella, Ettore; Zhang, Xiaoyan

Introduction to thematic series: protein interactions, structures, and networks

专题系列导论:蛋白质相互作用、结构和网络

Appella, Ettore; Jenkins, Lisa M Miller; Guengerich, F Peter

Genetic variants and mutations of PPM1D control the response to DNA damage

PPM1D的基因变异和突变控制着对DNA损伤的反应。

Dudgeon, Crissy; Shreeram, Sathyavageeswaran; Tanoue, Kan; Mazur, Sharlyn J; Sayadi, Ahmed; Robinson, Robert C; Appella, Ettore; Bulavin, Dmitry V

Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1)

丝氨酸/苏氨酸磷酸酶PPM1D(Wip1)环肽抑制剂的优化

Ryo Hayashi, Kan Tanoue, Stewart R Durell, Deb K Chatterjee, Lisa M Miller Jenkins, Daniel H Appella, Ettore Appella