日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into the therapeutic properties of delta opioid receptor

对δ阿片受体治疗特性的机制性见解

Bernhard, Sarah M; Roy Chowdhury, Susovan; Murata, Tsuyoshi; Reinl, Erin L; Ramos-Gonzalez, Nokomis; Denn, Elizabeth; Appourchaux, Kevin; Inoue, Asuka; England, Sarah K; Fay, Jonathan F; Majumdar, Susruta; Chanda, Baron; Che, Tao

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

μ-阿片受体正向变构调节剂的发现和动态药理学

O'Brien, Evan S; Wang, Junzheng; Tanguturi, Parthasaradhireddy; Li, Mengchu; White, Elizabeth; Shiimura, Yuki; Paul, Barnali; Appourchaux, Kevin; Kumar, Kaavya Krishna; Huang, Weijiao; Majumdar, Susruta; Traynor, John R; Streicher, John M; Chen, Chunlai; Kobilka, Brian K

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Total synthesis and biological activity of "carbamorphine": O-to-CH(2) replacement in the E-ring of the morphine core structure.

“卡巴吗啡”的全合成及生物活性:吗啡核心结构E环中的O-到-CH(2)取代

Akiyama Sota, Ople Rohini S, Kremsmair Alexander, Ramos-Gonzalez Nokomis, Nedungadan Thomas, Kennedy Brandon J, Appourchaux Kevin, Eans Shainnel O, Tsai Bowen A, Kraml Christina, Huang Xi-Ping, McLaughlin Jay P, Majumdar Susruta, Sarpong Richmond

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

A µ-opioid receptor modulator that works cooperatively with naloxone.

一种与纳洛酮协同作用的μ-阿片受体调节剂

O'Brien Evan S, Rangari Vipin Ashok, El Daibani Amal, Eans Shainnel O, Hammond Haylee R, White Elizabeth, Wang Haoqing, Shiimura Yuki, Krishna Kumar Kaavya, Jiang Qianru, Appourchaux Kevin, Huang Weijiao, Zhang Chensong, Kennedy Brandon J, Mathiesen Jesper M, Che Tao, McLaughlin Jay P, Majumdar Susruta, Kobilka Brian K

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

配体与μ阿片受体钠位点的水分子相互作用介导的信号调控

Ople, Rohini S; Ramos-Gonzalez, Nokomis; Li, Qiongyu; Sobecks, Briana L; Aydin, Deniz; Powers, Alexander S; Faouzi, Abdelfattah; Polacco, Benjamin J; Bernhard, Sarah M; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel O; Tsai, Bowen A; Dror, Ron O; Varga, Balazs R; Wang, Haoqing; Hüttenhain, Ruth; McLaughlin, Jay P; Majumdar, Susruta

Structure-based design of bitopic ligands for the µ-opioid receptor

基于结构的μ-阿片受体双位点配体设计

Faouzi, Abdelfattah; Wang, Haoqing; Zaidi, Saheem A; DiBerto, Jeffrey F; Che, Tao; Qu, Qianhui; Robertson, Michael J; Madasu, Manish K; El Daibani, Amal; Varga, Balazs R; Zhang, Tiffany; Ruiz, Claudia; Liu, Shan; Xu, Jin; Appourchaux, Kevin; Slocum, Samuel T; Eans, Shainnel O; Cameron, Michael D; Al-Hasani, Ream; Pan, Ying Xian; Roth, Bryan L; McLaughlin, Jay P; Skiniotis, Georgios; Katritch, Vsevolod; Kobilka, Brian K; Majumdar, Susruta

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor

κ-阿片受体肽-药物偶联配体的设计和结构验证

Edin Muratspahić #,Kristine Deibler #,Jianming Han #,Nataša Tomašević,Kirtikumar B Jadhav,Aina-Leonor Olivé-Marti,Nadine Hochrainer,Roland Hellinger,Johannes Koehbach,Jonathan F Fay,Mohammad Homaidur Rahman,Lamees Hegazy,Timothy W Craven,Balazs R Varga,Gaurav Bhardwaj,Kevin Appourchaux,Susruta Majumdar,Markus Muttenthaler,Parisa Hosseinzadeh,David J Craik,Mariana Spetea,Tao Che,David Baker,Christian W Gruber