日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity

TGN1412 抗 CD28 单克隆抗体下铰链突变可产生特异性 FcγRIIb 结合并保留超级激动剂活性

Alicia M Chenoweth, Sandra Esparon, Bruce D Wines, Janine Schuurman, Aran F Labrijn, P Mark Hogarth

Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

利用双特异性抗体靶向人类 CD73 上的两个不同表位可提高抗癌活性

Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren Wk Hansen, Morten F Gjerstorff, Christa E Müller, Paul Whi Parren, Henrik J Ditzel

FcγR Binding and ADCC Activity of Human IgG Allotypes

人 IgG 同种异型的 FcγR 结合和 ADCC 活性

Steven W de Taeye, Arthur E H Bentlage, Mirjam M Mebius, Joyce I Meesters, Suzanne Lissenberg-Thunnissen, David Falck, Thomas Sénard, Nima Salehi, Manfred Wuhrer, Janine Schuurman, Aran F Labrijn, Theo Rispens, Gestur Vidarsson

CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory

CD3 双特异性抗体疗法将实体肿瘤转变为炎症部位,但不会安装保护性记忆

Hreinn Benonisson, Işıl Altıntaş, Marjolein Sluijter, Sandra Verploegen, Aran F Labrijn, Danita H Schuurhuis, Mischa A Houtkamp, J Sjef Verbeek, Janine Schuurman, Thorbald van Hall

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies

控制 Fab 臂交换形成双特异性免疫球蛋白 G1 抗体的动力学机制

Dennis R Goulet, Steven J Orcutt, Adam Zwolak, Theo Rispens, Aran F Labrijn, Rob N de Jong, William M Atkins, Mark L Chiu

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

高效生成双特异性鼠抗体,用于同源啮齿动物模型中的临床前研究

Aran F Labrijn, Joyce I Meesters, Matthew Bunce, Anthony A Armstrong, Sandeep Somani, Tom C Nesspor, Mark L Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W H I Parren

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

铰链缺失型 IgG4 阻断剂治疗恒河猴乙酰胆碱受体重症肌无力

Mario Losen, Aran F Labrijn, Vivianne H van Kranen-Mastenbroek, Maarten L Janmaat, Krista G Haanstra, Frank J Beurskens, Tom Vink, Margreet Jonker, Bert A 't Hart, Marina Mané-Damas, Peter C Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H de Baets, Paul W H I Parren

Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches

通过控制 Fab 臂交换生产稳定的双特异性 IgG1:通过应用标准方法实现从实验室到大规模生产的可扩展性

Michael J Gramer, Ewald T J van den Bremer, Muriel D van Kampen, Amitava Kundu, Peter Kopfmann, Eric Etter, David Stinehelfer, Justin Long, Tom Lannom, Esther H Noordergraaf, Jolanda Gerritsen, Aran F Labrijn, Janine Schuurman, Patrick H C van Berkel, Paul W H I Parren

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

CH3 结构域中 Y407 的突变显著改变了人类 IgG 的糖基化和结构

Rebecca J Rose, Patrick H C van Berkel, Ewald T J van den Bremer, Aran F Labrijn, Tom Vink, Janine Schuurman, Albert J R Heck, Paul W H I Parren