日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting of a Bile Acid Receptor, Takeda G Protein Receptor 5 [TGR5], by a Novel First-in-Class Competitive Antagonist, SBI-364, Diminishes Hepatic and Renal Cystogenesis in Polycystic Liver and Kidney Disease

新型首创竞争性拮抗剂SBI-364靶向胆汁酸受体——武田G蛋白受体5 [TGR5],可减少多囊肝肾疾病中的肝肾囊肿形成。

Masyuk, Tetyana; Masyuk, Anatoliy; Trussoni, Christy; Lorenzo-Pisarello, Maria; Ardecky, Robert; Pinkerton, Anthony; Sergienko, Edward; Olson, Steven; Zou, Jiwen; Ganji, Santhi Reddy; Kramer, Bryan; Vuong, Krystine; Jankowski, She-Chia; Ma, Chen-Ting; Holleran, John; Pollari, Sirkku; Brown, Brock; Ramachandra, Raghuveer; Chung, Thomas; Turner, Carys; Morgenthaler, Olivia; Kawashima, Hanako; LaRusso, Nicholas

Structure-activity relationships of thiadiazole agonists of the human secretin receptor

人类促胰液素受体噻二唑激动剂的构效关系

Robert Ardecky, Daniela G Dengler, Kaleeckal G Harikumar, Mathew M Abelman, Jiwen Zou, Bryan A Kramer, Santhi Reddy Ganji, Steve Olson, Alina Ly, Nikhil Puvvula, Chen-Ting Ma, Raghuveer Ramachandra, Eduard A Sergienko, Laurence J Miller

Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells

发现针对白血病细胞中致癌酪氨酸磷酸酶 SHP2 的新型呋喃苯甲酰胺抑制剂

Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J Lambert, Maria Celeridad, Ming Zhao, Karina Barbosa, Laurent J S De Backer, Elizabeth Kwong, Palak Gosalia, Socorro Rodiles, John Holleran, Robert Ardecky, Stefan Grotegut, Steven Olson, John H Hutchinson, Elena B Pasquale, Kri

Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth

丝氨酸-苏氨酸激酶 TAO3 介导的含有侵袭性伪足支架 TKS5α 的内体运输促进癌症侵袭和肿瘤生长

Shinji Iizuka #, Manuela Quintavalle #, Jose C Navarro, Kyle P Gribbin, Robert J Ardecky, Matthew M Abelman, Chen-Ting Ma, Eduard Sergienko, Fu-Yue Zeng, Ian Pass, George V Thomas, Shannon K McWeeney, Christian A Hassig, Anthony B Pinkerton, Sara A Courtneidge

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase

发现口服生物可利用的低分子量蛋白酪氨酸磷酸酶嘌呤类抑制剂

Stephanie M Stanford, Michael A Diaz, Robert J Ardecky, Jiwen Zou, Tarmo Roosild, Zachary J Holmes, Tiffany P Nguyen, Michael P Hedrick, Socorro Rodiles, April Guan, Stefan Grotegut, Eugenio Santelli, Thomas D Y Chung, Michael R Jackson, Nunzio Bottini, Anthony B Pinkerton

Discovery of small molecule positive allosteric modulators of the secretin receptor

发现促胰液素受体的小分子正变构调节剂

Daniela G Dengler, Kaleeckal G Harikumar, Sirkku Pollari, Qing Sun, Brock T Brown, Aki Shinoki-Iwaya, Robert Ardecky, Laurence J Miller, Eduard A Sergienko

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

开发用于鉴定针对促胰液素受体的小分子调节剂的测试漏斗

Daniela G Dengler, Qing Sun, John Holleran, Sirkku Pollari, Jannis Beutel, Brock T Brown, Aki Shinoki Iwaya, Robert Ardecky, Kaleeckal G Harikumar, Laurence J Miller, Eduard A Sergienko

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

TGR5通过环磷酸腺苷/Gαs信号通路促进多囊肝病啮齿动物的肝囊肿形成。

Masyuk, Tatyana V; Masyuk, Anatoliy I; Lorenzo Pisarello, Maria; Howard, Brynn N; Huang, Bing Q; Lee, Pui-Yuen; Fung, Xavier; Sergienko, Eduard; Ardecky, Robert J; Chung, Thomas D Y; Pinkerton, Anthony B; LaRusso, Nicholas F

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

通过抑制低分子量酪氨酸磷酸酶逆转糖尿病

Stephanie M Stanford, Alexander E Aleshin, Vida Zhang, Robert J Ardecky, Michael P Hedrick, Jiwen Zou, Santhi R Ganji, Matthew R Bliss, Fusayo Yamamoto, Andrey A Bobkov, Janna Kiselar, Yingge Liu, Gregory W Cadwell, Shilpi Khare, Jinghua Yu, Antonio Barquilla, Thomas D Y Chung, Tomas Mustelin, Simon

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis

鉴定有效的 SMAC 模拟物,该模拟物可使癌细胞对 TNF 家族诱导的细胞凋亡敏感

Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosford