日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation

干扰 LSD1 和 WNT 可重编转录,从而协同诱导 AML 分化。

Amir Hosseini # ,Abhinav Dhall # ,Nemo Ikonen ,Natalia Sikora ,Sylvain Nguyen ,Yuqi Shen ,Maria Luisa Jurgensen Amaral ,Alan Jiao ,Felice Wallner ,Philipp Sergeev ,Yuhua Lim ,Yuanqin Yang ,Binje Vick ,Kimihito Cojin Kawabata ,Ari Melnick ,Paresh Vyas ,Bing Ren ,Irmela Jeremias ,Bethan Psaila ,Caroline A Heckman ,M Andrés Blanco ,Yang Shi

SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions

SMARCA4 是一种单倍体不足的 B 细胞淋巴瘤抑癌基因,它精细调控中心细胞的命运决定。

Qing Deng ,Priya Lakra ,Panhong Gou ,Haopeng Yang ,Cem Meydan ,Matthew Teater ,Christopher Chin ,Wenchao Zhang ,Tommy Dinh ,Usama Hussein ,Xubin Li ,Estela Rojas ,Weiguang Liu ,Patrick K Reville ,Atish Kizhakeyil ,Darko Barisic ,Sydney Parsons ,Ashley Wilson ,Jared Henderson ,Brooks Scull ,Channabasavaiah Gurumurthy ,Francisco Vega ,Amy Chadburn ,Branko Cuglievan ,Nader Kim El-Mallawany ,Carl Allen ,Christopher Mason ,Ari Melnick ,Michael R Green

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

ARID1A 协调 SWI/SNF 介导的转录因子顺序结合,ARID1A 缺失驱动前记忆 B 细胞命运和淋巴瘤发生。

Darko Barisic ,Christopher R Chin ,Cem Meydan ,Matt Teater ,Ioanna Tsialta ,Coraline Mlynarczyk ,Amy Chadburn ,Xuehai Wang ,Margot Sarkozy ,Min Xia ,Sandra E Carson ,Santo Raggiri ,Sonia Debek ,Benedikt Pelzer ,Ceyda Durmaz ,Qing Deng ,Priya Lakra ,Martin Rivas ,Christian Steidl ,David W Scott ,Andrew P Weng ,Christopher E Mason ,Michael R Green ,Ari Melnick

Profiling the activity of the para-caspase MALT1 in B-cell acute lymphoblastic leukemia for potential targeted therapeutic application

分析 B 细胞急性淋巴细胞白血病中副胱天蛋白酶 MALT1 的活性,以用于潜在的靶向治疗应用

Firas M Safa, Terri Rasmussen, Lorena Fontan, Min Xia, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Jan A Burger, Yara Mouawad, Hana Safah, Erik K Flemington, Nakhle S Saba

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9

人类 B 细胞活化的多组学分析揭示溶酶体 BCAT1 在 B 细胞受体和 TLR9 导致的 mTOR 过度活化中发挥关键作用

Benjamin Gewurz, Rui Guo, Matthew Lim, Hardik Shah, Joao Paulo, Yuchen Zhang, Haopeng Yang, Liang Wei Wang, Daniel Strebinger, Nicolas Smith, Meng Li, Merrin Leong, Michael Lutchenkov, Jin-Hua Liang, Zhixuan Li, Yin Wang, Rishi Puri, Ari Melnick, Michael Green, John Asara, Adonia Papathanassiu, Stev

MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression

MALT1 蛋白酶抑制通过逆转肿瘤相关巨噬细胞依赖性免疫抑制来抑制胶质母细胞瘤进展

Juliana Hofstätter Azambuja, Saigopalakrishna S Yerneni, Lisa M Maurer, Hannah E Crentsil, Gabriela N Debom, Linda Klei, Mei Smyers, Chaim T Sneiderman, Kristina E Schwab, Rajesh Acharya, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete J Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Pe

BTG1 mutation yields supercompetitive B cells primed for malignant transformation

BTG1突变产生具有超强竞争力的B细胞,这些B细胞易于发生恶性转化。

Coraline Mlynarczyk ,Matt Teater ,Juhee Pae ,Christopher R Chin ,Ling Wang ,Theinmozhi Arulraj ,Darko Barisic ,Antonin Papin ,Kenneth B Hoehn ,Ekaterina Kots ,Jonatan Ersching ,Arnab Bandyopadhyay ,Ersilia Barin ,Hui Xian Poh ,Chiara M Evans ,Amy Chadburn ,Zhengming Chen ,Hao Shen ,Hannah M Isles ,Benedikt Pelzer ,Ioanna Tsialta ,Ashley S Doane ,Huimin Geng ,Muhammad Hassan Rehman ,Jonah Melnick ,Wyatt Morgan ,Diu T T Nguyen ,Olivier Elemento ,Michael G Kharas ,Samie R Jaffrey ,David W Scott ,George Khelashvili ,Michael Meyer-Hermann ,Gabriel D Victora ,Ari Melnick

Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

联合治疗可逆转肿瘤微环境介导的MALT1抑制剂在B细胞淋巴瘤中的减弱作用

Shivem B Shah ,Christopher R Carlson ,Kristine Lai ,Zhe Zhong ,Grazia Marsico ,Katherine M Lee ,Nicole E Félix Vélez ,Elisabeth B Abeles ,Mayar Allam ,Thomas Hu ,Lauren D Walter ,Karen E Martin ,Khanjan Gandhi ,Scott D Butler ,Rishi Puri ,Angela L McCleary-Wheeler ,Wayne Tam ,Olivier Elemento ,Katsuyoshi Takata ,Christian Steidl ,David W Scott ,Lorena Fontan ,Hideki Ueno ,Benjamin D Cosgrove ,Giorgio Inghirami ,Andrés J García ,Ahmet F Coskun ,Jean L Koff ,Ari Melnick ,Ankur Singh

Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response

Bach2蛋白和RNA表达的差异性调控决定了早期B细胞反应中的细胞命运

Qianwen Hu ,Tingting Xu ,Min Zhang ,Heng Zhang ,Yongbo Liu ,Hua-Bing Li ,Chiqi Chen ,Junke Zheng ,Zhen Zhang ,Fubin Li ,Nan Shen ,Wenqian Zhang ,Ari Melnick ,Chuanxin Huang

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

胚胎滞育样适应伴随Myc活性抑制,使肿瘤治疗得以持续

Eugen Dhimolea ,Ricardo de Matos Simoes ,Dhvanir Kansara ,Aziz Al'Khafaji ,Juliette Bouyssou ,Xiang Weng ,Shruti Sharma ,Joseline Raja ,Pallavi Awate ,Ryosuke Shirasaki ,Huihui Tang ,Brian J Glassner ,Zhiyi Liu ,Dong Gao ,Jordan Bryan ,Samantha Bender ,Jennifer Roth ,Michal Scheffer ,Rinath Jeselsohn ,Nathanael S Gray ,Irene Georgakoudi ,Francisca Vazquez ,Aviad Tsherniak ,Yu Chen ,Alana Welm ,Cihangir Duy ,Ari Melnick ,Boris Bartholdy ,Myles Brown ,Aedin C Culhane ,Constantine S Mitsiades