日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Human intestinal enteroids: Nonclinical applications for predicting oral drug disposition, toxicity, and efficacy

人类肠道类器官：预测口服药物处置、毒性和疗效的非临床应用

期刊:Pharmacology & Therapeutics
影响因子:12.5
doi:10.1016/j.pharmthera.2025.108879
O'Mahony, Eimear T; Arian, Christopher M; Aryeh, Kayenat S; Wang, Kai; Thummel, Kenneth E; Kelly, Edward J
3D/类器官
Human
毒理研究
发表日期：2025
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Leveraging RNA-seq deconvolution to improve complex in vitro model characterization

利用RNA-seq反卷积技术改进复杂体外模型表征

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110510
Hansen, Brad C; Arian, Christopher M; Zeng, Yuting; Takezawa, Meg G; Theberge, Ashleigh B; Faustman, Elaine M; Thummel, Kenneth E; Kelly, Edward J
发表日期：2025
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A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption

肠道反应：应用人肠类器官单层细胞探究北美黄连介导的二甲双胍肠道吸收抑制机制

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1016/j.jpet.2025.103597
Arian, Christopher M; O'Mahony, Eimear T; Manwill, Preston K; Graf, Tyler N; Oberlies, Nicholas H; Cech, Nadja B; Clarke, John D; Smith, Jason G; Paine, Mary F; Kelly, Edward J; Thummel, Kenneth E
3D/类器官
细胞生物学
发表日期：2025
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The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

二甲双胍与天然产物金印草之间的药代动力学相互作用与二甲双胍剂量相关：一项针对 2 型糖尿病成年患者的三臂交叉研究

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70120
Nguyen James T, Arian Christopher M, Tanna Rakshit S, Cherel Maxey G, Layton Matthew E, White John R, Thummel Kenneth E, Paine Mary F
代谢
糖尿病
发表日期：2025
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An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations

阐明北美黄连-咪达唑仑药代动力学相互作用机制的综合方法：应用体外试验和基于生理的药代动力学模型理解临床观察结果

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.8
doi:10.1124/jpet.123.001681
Nguyen, James T; Tian, Dan-Dan; Tanna, Rakshit S; Arian, Christopher M; Calamia, Justina C; Rettie, Allan E; Thummel, Kenneth E; Paine, Mary F
发表日期：2023
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Gutsy science: In vitro systems of the human intestine to model oral drug disposition

大胆的科学：利用体外人体肠道系统模拟口服药物的处置

期刊:Pharmacology & Therapeutics
影响因子:12.5
doi:10.1016/j.pharmthera.2021.107962
Arian, Christopher M; Imaoka, Tomoki; Yang, Jade; Kelly, Edward J; Thummel, Kenneth E
发表日期：2022
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