日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

直接生物学:简化药物发现中从化学到生物学的路径

Hübner, Ariane F; Barthels, Fabian

Nanoscale Direct-to-Biology Optimization and Structural Insights into Selective S. aureus TrmD Inhibitors

纳米尺度直接生物优化及选择性金黄色葡萄球菌TrmD抑制剂的结构解析

Hübner, Ariane F; Weldert, Annabelle C; Marciniak, Tessa; Hof, Florian; Beck, Vivien S; Carien, Samuel; Mulartschyk, Sophie N; Wolf, Eva; Ziebuhr, Wilma; Barthels, Fabian

NMR Analysis and Assignment of a Biosynthesis Gene Cluster for Trichokonins VI and VIII, Antiplasmodial Large Peptaibols Produced by a Trichoderma sp. Fungus

对木霉属真菌产生的抗疟原虫大肽类化合物——毛霉素VI和VIII的生物合成基因簇进行核磁共振分析和鉴定

Bertonha, Ariane F; Williams, David E; Nicacio, Karen J; de Amorim, Marcelo R; Schoellhorn, Sydney M; Aguiar, Anna Caroline C; Valdes, Talita Alvarenga; Mendes, Giovana Rossi; Moura, Igor M R; Michaliski, Lamonielli F; Gotha, Matheus; Zuccarino, Caue A W; Sette, Lara D; Ferreira, Antônio G; Andersen, Raymond J; Guido, Rafael Victorio Carvalho; Berlinck, Roberto G S

DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site.

DNA编码文库筛选发现了靶向隐蔽变构结合位点的强效DNMT2抑制剂

Frey Ariane F, Schwan Merlin, Weldert Annabelle C, Kadenbach Valerie, Kopp Jürgen, Nidoieva Zarina, Zimmermann Robert A, Gleue Lukas, Zimmer Collin, Jörg Marko, Friedland Kristina, Helm Mark, Sinning Irmgard, Barthels Fabian

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype.

结构导向设计甲基转移酶样 3 (METTL3) 蛋白水解靶向嵌合体 (PROTAC),其中包含吲哚-烟酰胺化学类型

Weldert Annabelle C, Frey Ariane F, Krone Mackenzie W, Krähe Franziska, Kuhn Hannah, Kersten Christian, Barthels Fabian

High-throughput protein crystallography to empower natural product-based drug discovery

高通量蛋白质晶体学助力基于天然产物的药物发现

Meneghello, Raphael; Rustiguel, Joane K; de Araújo, Evandro Ares; de Felício, Rafael; Fernandes, Arthur Zanetti N; Ferreira, Everton L F; Gubiani, Juliana R; Takeda, Agnes A S; Araujo, Amanda; de Lima Silva, Caio C; Bertonha, Ariane F; Urano, Raquel P M; Trindade, Daniel M; Cunha, Thiago M; Cardoso, Alisson C; Berlinck, Roberto G S; Nascimento, Andrey F Ziem; Trivella, Daniela B B

Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer

连接多个微环境蛋白质组揭示头颈癌的生物学机制

Busso-Lopes, Ariane F; Neves, Leandro X; Câmara, Guilherme A; Granato, Daniela C; Pretti, Marco Antônio M; Heberle, Henry; Patroni, Fábio M S; Sá, Jamile; Yokoo, Sami; Rivera, César; Domingues, Romênia R; Normando, Ana Gabriela C; De Rossi, Tatiane; Mello, Barbara P; Galdino, Nayane A L; Pauletti, Bianca A; Lacerda, Pammela A; Rodrigues, André Afonso N; Casarim, André Luis M; de Lima-Souza, Reydson A; Damas, Ingrid I; Mariano, Fernanda V; Gollob, Kenneth J; Medina, Tiago S; Cervigne, Nilva K; Prado-Ribeiro, Ana Carolina; Brandão, Thaís Bianca; Villa, Luisa L; Uno, Miyuki; Boroni, Mariana; Kowalski, Luiz Paulo; González-Arriagada, Wilfredo Alejandro; Paes Leme, Adriana F

Metabolomics Reveals Minor Tambjamines in a Marine Invertebrate Food Chain

代谢组学揭示海洋无脊椎动物食物链中的微量坦布胺类物质

Takaki, Mirelle; Freire, Vítor F; Nicacio, Karen J; Bertonha, Ariane F; Nagashima, Nozomu; Sarpong, Richmond; Padula, Vinicius; Ferreira, Antonio G; Berlinck, Roberto G S

Pleiotropic Effect of Hormone Insulin-Like Growth Factor-I in Immune Response and Pathogenesis in Leishmaniases

激素胰岛素样生长因子-I在利什曼病免疫反应和发病机制中的多效性作用

Reis, Luiza C; Ramos-Sanchez, Eduardo Milton; Araujo, Fernanda N; Leal, Ariane F; Ozaki, Christiane Y; Sevillano, Orlando R; Uscata, Bernardina A; Goto, Hiro

Synthesis of Agelastatin A and Derivatives Premised on a Hidden Symmetry Element Leading to Analogs Displaying Anticancer Activity

基于隐藏对称元素的Agelastatin A及其衍生物的合成,得到具有抗癌活性的类似物

Xue, Haoran; Svatek, Haleigh; Bertonha, Ariane F; Reisenauer, Keighley; Robinson, Joshua; Kim, Minwoo; Ingros, Alec; Ho, Matthew; Taube, Joseph; Romo, Daniel