日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants

SARS-CoV-2 感染气道类器官揭示了祖先型、Delta 型和 Omicron 型变体对四跨膜蛋白-8 的保守利用

Hysenaj, Lisiena; Little, Samantha; Kulhanek, Kayla; Magnen, Melia; Bahl, Kriti; Gbenedio, Oghenekevwe M; Prinz, Morgan; Rodriguez, Lauren; Andersen, Christopher; Rao, Arjun Arkal; Shen, Alan; Lone, Jean-Christophe; Lupin-Jimenez, Leonard C; Bonser, Luke R; Serwas, Nina K; Mick, Eran; Khalid, Mir M; Taha, Taha Y; Kumar, Renuka; Li, Jack Z; Ding, Vivianne W; Matsumoto, Shotaro; Maishan, Mazharul; Sreekumar, Bharath; Simoneau, Camille; Nazarenko, Irina; Tomlinson, Michael G; Khan, Khajida; von Gottberg, Anne; Sigal, Alex; Looney, Mark R; Fragiadakis, Gabriela K; Jablons, David M; Langelier, Charles R; Matthay, Michael; Krummel, Matthew; Erle, David J; Combes, Alexis J; Sil, Anita; Ott, Melanie; Kratz, Johannes R; Roose, Jeroen P

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

通过治疗性阻断IL-6信号通路可以降低与COVID-19严重程度相关的髓系程序。

Jason A Hackney ,Haridha Shivram ,Jason Vander Heiden ,Chris Overall ,Luz Orozco ,Xia Gao ,Eugene Kim ,Nathan West ,Aditi Qamra ,Diana Chang ,Arindam Chakrabarti ,David F Choy ,Alexis J Combes ,Tristan Courau ,Gabriela K Fragiadakis ,Arjun Arkal Rao ,Arja Ray ,Jessica Tsui ,Kenneth Hu ,Nicholas F Kuhn ,Matthew F Krummel ,David J Erle ,Kirsten Kangelaris ,Aartik Sarma ,Zoe Lyon ,Carolyn S Calfee ,Prescott G Woodruff ,Rajani Ghale ,Eran Mick ,Ashley Byrne ,Beth Shoshana Zha ,Charles Langelier ,Carolyn M Hendrickson ,Monique G P van der Wijst ,George C Hartoularos ,Tianna Grant ,Raymund Bueno ,David S Lee ,John R Greenland ,Yang Sun ,Richard Perez ,Anton Ogorodnikov ,Alyssa Ward ,Chun Jimmie Ye ,Jacqueline M McBride ,Fang Cai ,Anastasia Teterina ,Min Bao ,Larry Tsai ,Ivan O Rosas ,Aviv Regev ,Sharookh B Kapadia ,Rebecca N Bauer ,Carrie M Rosenberger

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

癌症中巨噬细胞与耗竭CD8+ T细胞之间的时空共依赖性

Kelly Kersten ,Kenneth H Hu ,Alexis J Combes ,Bushra Samad ,Tory Harwin ,Arja Ray ,Arjun Arkal Rao ,En Cai ,Kyle Marchuk ,Jordan Artichoker ,Tristan Courau ,Quanming Shi ,Julia Belk ,Ansuman T Satpathy ,Matthew F Krummel

Discovering dominant tumor immune archetypes in a pan-cancer census

在泛癌普查中发现主要的肿瘤免疫原型

Alexis J Combes ,Bushra Samad ,Jessica Tsui ,Nayvin W Chew ,Peter Yan ,Gabriella C Reeder ,Divyashree Kushnoor ,Alan Shen ,Brittany Davidson ,Andrea J Barczak ,Michael Adkisson ,Austin Edwards ,Mohammad Naser ,Kevin C Barry ,Tristan Courau ,Taymour Hammoudi ,Rafael J Argüello ,Arjun Arkal Rao ,Adam B Olshen ,Jenny Zhan ,Katelyn C Davis ,Robin K Kelley ,Jocelyn S Chapman ,Chloe E Atreya ,Amar Patel ,Adil I Daud ,Patrick Ha ,Aaron A Diaz ,Johannes R Kratz ,Eric A Collisson ,Gabriela K Fragiadakis ,David J Erle ,Alexandre Boissonnas ,Saurabh Asthana ,Vincent Chan ,Matthew F Krummel

Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer's Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions

对公开的单核转录组学阿尔茨海默病数据集进行生物信息学分析,揭示了APOE基因型在两个脑区不同细胞类型中的特异性变化

Belonwu, Stella A; Li, Yaqiao; Bunis, Daniel G; Rao, Arjun Arkal; Solsberg, Caroline Warly; Oskotsky, Tomiko; Taubes, Alice L; Grone, Brian; Zalocusky, Kelly A; Fragiadakis, Gabriela K; Huang, Yadong; Sirota, Marina

Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer's Disease Across Two Brain Regions

基于性别分层的单细胞RNA测序分析揭示了阿尔茨海默病在两个脑区中存在的性别特异性和细胞类型特异性转录反应

Belonwu, Stella A; Li, Yaqiao; Bunis, Daniel; Rao, Arjun Arkal; Solsberg, Caroline Warly; Tang, Alice; Fragiadakis, Gabriela K; Dubal, Dena B; Oskotsky, Tomiko; Sirota, Marina

Global absence and targeting of protective immune states in severe COVID-19

全球范围内,重症新冠肺炎患者的保护性免疫状态缺失或受到攻击

Alexis J Combes # ,Tristan Courau # ,Nicholas F Kuhn # ,Kenneth H Hu # ,Arja Ray # ,William S Chen ,Nayvin W Chew ,Simon J Cleary ,Divyashree Kushnoor ,Gabriella C Reeder ,Alan Shen ,Jessica Tsui ,Kamir J Hiam-Galvez ,Priscila Muñoz-Sandoval ,Wandi S Zhu ,David S Lee ,Yang Sun ,Ran You ,Mélia Magnen ,Lauren Rodriguez ,K W Im ,Nina K Serwas ,Aleksandra Leligdowicz ,Colin R Zamecnik ,Rita P Loudermilk ,Michael R Wilson ,Chun J Ye ,Gabriela K Fragiadakis ,Mark R Looney ,Vincent Chan ,Alyssa Ward ,Sidney Carrillo ,David J Erle ,Prescott G Woodruff ,Charles Langelier ,Kirsten Kangelaris ,Carolyn M Hendrickson ,Carolyn Calfee ,Arjun Arkal Rao ,Matthew F Krummel

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I型干扰素自身抗体与COVID-19患者的全身免疫改变有关。

Monique G P van der Wijst ,Sara E Vazquez ,George C Hartoularos ,Paul Bastard ,Tianna Grant ,Raymund Bueno ,David S Lee ,John R Greenland ,Yang Sun ,Richard Perez ,Anton Ogorodnikov ,Alyssa Ward ,Sabrina A Mann ,Kara L Lynch ,Cassandra Yun ,Diane V Havlir ,Gabriel Chamie ,Carina Marquez ,Bryan Greenhouse ,Michail S Lionakis ,Philip J Norris ,Larry J Dumont ,Kathleen Kelly ,Peng Zhang ,Qian Zhang ,Adrian Gervais ,Tom Le Voyer ,Alexander Whatley ,Yichen Si ,Ashley Byrne ,Alexis J Combes ,Arjun Arkal Rao ,Yun S Song ,Gabriela K Fragiadakis ,Kirsten Kangelaris ,Carolyn S Calfee ,David J Erle ,Carolyn Hendrickson ,Matthew F Krummel ,Prescott G Woodruff ,Charles R Langelier ,Jean-Laurent Casanova ,Joseph L Derisi ,Mark S Anderson ,Chun Jimmie Ye

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

携带 HLA-C*04:01 基因者罹患 COVID-19 重症的风险增加

January Weiner ,Phillip Suwalski ,Manuel Holtgrewe ,Alexander Rakitko ,Charlotte Thibeault ,Melina Müller ,Dimitri Patriki ,Claudia Quedenau ,Ulrike Krüger ,Valery Ilinsky ,Iaroslav Popov ,Joseph Balnis ,Ariel Jaitovich ,Elisa T Helbig ,Lena J Lippert ,Paula Stubbemann ,Luis M Real ,Juan Macías ,Juan A Pineda ,Marta Fernandez-Fuertes ,Xiaomin Wang ,Zehra Karadeniz ,Jacopo Saccomanno ,Jan-Moritz Doehn ,Ralf-Harto Hübner ,Bernd Hinzmann ,Mauricio Salvo ,Anja Blueher ,Sandra Siemann ,Stjepan Jurisic ,Juerg H Beer ,Jonas Rutishauser ,Benedikt Wiggli ,Hansruedi Schmid ,Kathrin Danninger ,Ronald Binder ,Victor M Corman ,Barbara Mühlemann ,Rao Arjun Arkal ,Gabriela K Fragiadakis ,Eran Mick ,Consortium Comet ,Carolyn S Calfee ,David J Erle ,Carolyn M Hendrickson ,Kirsten N Kangelaris ,Matthew F Krummel ,Prescott G Woodruff ,Charles R Langelier ,Urmila Venkataramani ,Federico García ,Joanna Zyla ,Christian Drosten ,Braun Alice ,Terry C Jones ,Norbert Suttorp ,Martin Witzenrath ,Stefan Hippenstiel ,Tomasz Zemojtel ,Carsten Skurk ,Wolfgang Poller ,Tatiana Borodina ,Study Group Pa-Covid ,Stephan Ripke ,Leif E Sander ,Dieter Beule ,Ulf Landmesser ,Toumy Guettouche ,Florian Kurth ,Bettina Heidecker

Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature

通过新表位负荷和 APOBEC 特征预测复发性宫颈透明细胞腺癌青少年患者对 PD-1 抑制的完全缓解

Anya Levinson, Alex G Lee, Henry J Martell, Marcus R Breese, Charles Zaloudek, Jessica Van Ziffle, Benjamin Laguna, Stanley G Leung, M Dwight Chen, Lee-May Chen, Jacob Pfeil, Nicholas R Ladwig, Avanthi Tayi Shah, Inge Behroozfard, Arjun Arkal Rao, Sofie R Salama, E Alejandro Sweet-Cordero, Elliot St