日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

针对 14-3-3/ERα 复合物的分子胶的支架跃迁

Konstantinidou Markella, Zingiridis Marios, Pennings Marloes A M, Fragkiadakis Michael, Virta Johanna M, Revalde Jezrael L, Visser Emira J, Ottmann Christian, Brunsveld Luc, Neochoritis Constantinos G, Arkin Michelle R

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.

吞噬受体 MERTK 和 AXL 在前粒蛋白缺乏型 FTD 中的相反作用

Clelland Claire Dudley, Fan Li, Saloner Rowan, Etchegaray Jon Iker, Altobelli Chad Richard, Salomonsson Sally, Maltos Alisha M, Sachdev Aradhana, Zhu Jingjie, Lee Se-In, Li Yaqiao, Zhou Yungui, Le David, Wang Chao, Carling Gillian, Kodama Lay, Sayed Faten, Perez-Bermejo Jaun A, Geier Ethan G, Yokoyama Jennifer S, Rosen Howie, Nana Alissa L, Spina Salvatore, Grinberg Lea T, Seeley William W, Elahi Fanny, Boxer Adam L, Arkin Michelle R, Gan Li

Synthetic autophagy receptor

合成自噬受体

Jiang, Ziwen; Kuo, Yu-Hsuan; Arkin, Michelle R

Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.

利用 PARP 抑制剂对 CDK12 缺陷型前列腺癌进行合成致死靶向治疗

Chou Jonathan, Robinson Troy M, Egusa Emily A, Lodha Roshan, Zhang Meng, Badura Michelle, Mikayelyan Mane, Delavan Henry M, Swinderman Jason, Wilson Chris, Zhu Jun, Das Rajdeep, Nguyen Minh, Loehr Andrea, Golsorkhi Tony, Simmons Andrew, Abida Wassim, Chinnaiyan Arul M, Arkin Michelle R, Small Eric J, Quigley David A, Yang Lixing, Kim Minkyu, Ashworth Alan, Feng Felix Y

A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement

自上而下的蛋白质组学分析评估KRAS4B-化合物相互作用

D'Ippolito, Robert A; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R T; Scheidemantle, Grace M; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E; Stephen, Andrew G; Esposito, Dominic; McCormick, Frank; Nissley, Dwight V; DeHart, Caroline J

14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization

14-3-3 蛋白质-蛋白质相互作用:从机制理解到小分子稳定化

Somsen, Bente A; Cossar, Peter J; Arkin, Michelle R; Brunsveld, Luc; Ottmann, Christian

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation

受自噬受体启发的抗体融合蛋白用于靶向细胞内降解

Jiang, Ziwen; Kuo, Yu-Hsuan; Arkin, Michelle R

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments

基于非选择性片段的14-3-3σ/ERα蛋白-蛋白相互作用共价小分子稳定剂的结构优化

Konstantinidou, Markella; Visser, Emira J; Vandenboorn, Edmee; Chen, Sheng; Jaishankar, Priyadarshini; Overmans, Maurits; Dutta, Shubhankar; Neitz, R Jeffrey; Renslo, Adam R; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R

In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets.

基于体内多巴胺神经元成像的小分子筛选鉴定出新型神经保护化合物和靶点

Kim Gha-Hyun J, Mo Han, Liu Harrison, Okorie Meri, Chen Steven, Zheng Jiashun, Li Hao, Arkin Michelle, Huang Bo, Guo Su