日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stability and progressive differentiation of T(FR) cells are intrinsically and extrinsically controlled by T(FH) programs

T(FR)细胞的稳定性和逐步分化受到T(FH)程序内在和外在的调控。

Lee, Jeong-Mi; Raeder, Paulo Lisboa; Rashid, Ridwan B; Zhang, Hengcheng; Nelson, Cody S; Richardson, Sierra G; Burke, Kelly P; Chandrakar, Pragya; Podestà, Manuel A; Gempler, Maya G; Batty, Cole; Kong, Dejun; Gavzy, Samuel J; Shirkey, Marina W; Yang, Cyrus; Bromberg, Jonathan S; Haigis, Marcia C; Marasco, Wayne A; Sharpe, Arlene H; Sage, Peter T

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy

利用炎症性单核细胞克服抗PD-1免疫疗法的耐药性

Zimmerman, Matthew P; Huang, Amy Y; Cox, Emily K; Al Abosy, Rose; Chong, Wan Lin; Bastian, Alexander G; Vietor, Katherine; Choutri, Yacine; Collier, Jenna; Zhabotynsky, Vasyl; Wang, Haiyang; Fung, Megan; Weiss, Sarah A; Robitschek, Emily J; Lin, Jia-Ren; Vallius, Tuulia; Pant, Shishir M; Sorger, Peter K; Hugo, Willy; Sen, Debattama R; Haining, W Nicholas; Sharpe, Arlene H; Miller, Brian C

A STUB1-CHIC2 complex inhibits CD8(+) T cells to restrain tumor immunity

STUB1-CHIC2复合物抑制CD8(+) T细胞,从而抑制肿瘤免疫

LaFleur, Martin W; Milling, Lauren E; Prathima, Priyamvada; Li, Vivian; Lemmen, Ashlyn M; Streeter, Ivy S L; Heisig, Paul K S; Derosia, Nicole M; Riffo, Elizabeth; Xu, Haonan; Nguyen, Thao H; Kolengaden, Aashiya; Markson, Samuel C; Doench, John G; Sharpe, Arlene H

Single-Cell Analyses Reveal a Functionally Heterogeneous Exhausted CD8+ T-cell Subpopulation That Is Correlated with Response to Checkpoint Therapy in Melanoma

单细胞分析揭示了一种功能异质性的耗竭CD8+ T细胞亚群,该亚群与黑色素瘤对免疫检查点疗法的反应相关。

Kelly M Mahuron # ,Osmaan Shahid # ,Prachi Sao # ,Clinton Wu # ,Alexandra M Haugh ,Laura A Huppert ,Lauren S Levine ,Margaret M Lowe ,Michael Alvarado ,Markee Micu ,Katy K Tsai ,Melissa Chow ,Meromit Singer ,Jason M Schenkel ,Arlene H Sharpe ,Michael D Rosenblum ,Kristen E Pauken ,Adil I Daud

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion

PD-1以细胞内在和细胞外在两种方式调节肿瘤浸润的CD8+ T细胞。

Pauken, Kristen E; Markson, Samuel C; Conway, Thomas S; Juneja, Vikram R; Shahid, Osmaan; Burke, Kelly P; Rowe, Jared H; Nguyen, Thao H; Collier, Jenna L; Walsh, Jaclyn M L; Fung, Megan E; Luber, Jacob M; Ringel, Alison E; Schenkel, Jason M; Freeman, Gordon J; Haigis, Marcia C; Singer, Meromit; Sharpe, Arlene H

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

细胞外天冬酰胺的耗竭会损害自身反应性T细胞,并改善多发性硬化症小鼠模型中的自身免疫性疾病。

Georgiev, Peter; Johnson, Sheila; Kurmi, Kiran; Hu, Song-Hua; Han, SeongJun; Patterson, Dillon; Nguyen, Thao H; Huang, Linglin; Liang, Dan; Goldman, Naomi; Conway, Thomas; Creasey, Hannah; Rowe, Jared; Haigis, Marcia C; Sharpe, Arlene H

Neuropeptide signalling orchestrates T cell differentiation

神经肽信号传导调控T细胞分化

Hou, Yu; Sun, Linyu; LaFleur, Martin W; Huang, Linglin; Lambden, Conner; Thakore, Pratiksha I; Geiger-Schuller, Kathryn; Kimura, Kimitoshi; Yan, Longjun; Zang, Yue; Tang, Ruihan; Shi, Jingwen; Barilla, Rocky; Deng, Liwen; Subramanian, Ayshwarya; Wallrapp, Antonia; Choi, Hee Sun; Kye, Yoon-Chul; Ashenberg, Orr; Schiebinger, Geoffrey; Doench, John G; Chiu, Isaac M; Regev, Aviv; Sharpe, Arlene H; Kuchroo, Vijay K

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

LAG-3 维持 TOX 表达并调节 CD94/NKG2-Qa-1b 轴,从而控制耗竭 CD8 T 细胞 NK 受体的表达和细胞毒性。

Shin Foong Ngiow ,Sasikanth Manne ,Yinghui Jane Huang ,Tarek Azar ,Zeyu Chen ,Divij Mathew ,Qingzhou Chen ,Omar Khan ,Jennifer E Wu ,Victor Alcalde ,Ahron J Flowers ,Sean McClain ,Amy E Baxter ,Makoto Kurachi ,Junwei Shi ,Alexander C Huang ,Josephine R Giles ,Arlene H Sharpe ,Dario A A Vignali ,E John Wherry

LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

LAG-3 和 PD-1 在 CD8+ T 细胞上发挥协同作用,导致 T 细胞耗竭并抑制自分泌 IFN-γ 依赖性抗肿瘤免疫。

Lawrence P Andrews ,Samuel C Butler ,Jian Cui ,Anthony R Cillo ,Carly Cardello ,Chang Liu ,Erin A Brunazzi ,Andrew Baessler ,Bingxian Xie ,Sheryl R Kunning ,Shin Foong Ngiow ,Yinghui Jane Huang ,Sasikanth Manne ,Arlene H Sharpe ,Greg M Delgoffe ,E John Wherry ,John M Kirkwood ,Tulia C Bruno ,Creg J Workman ,Dario A A Vignali

X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system

X-CHIME 能够实现免疫系统中基因的组合、诱导、谱系特异性和顺序敲除

Martin W LaFleur, Ashlyn M Lemmen, Ivy S L Streeter, Thao H Nguyen, Lauren E Milling, Nicole M Derosia, Zachary M Hoffman, Jacob E Gillis, Qin Tjokrosurjo, Samuel C Markson, Amy Y Huang, Praju V Anekal, Paula Montero Llopis, W Nicholas Haining, John G Doench, Arlene H Sharpe