日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles.

开发具有增强的 HIV-1 非核苷类逆转录酶抑制剂,以提高其耐药性和药代动力学特性

Wang Zhao, Rumrill Shawn, Kang Dongwei, Guma Samuel Desta, Feng Da, De Clercq Erik, Pannecouque Christophe, Chen Chin Ho, Arnold Eddy, Ruiz Francesc Xavier, Liu Xinyong, Zhan Peng

Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals

登革病毒聚合酶晶体学片段筛选揭示了多个结合位点,可用于开发非核苷类抗黄病毒药物

Saini, Manisha; Aschenbrenner, Jasmin C; Ruiz, Francesc Xavier; Chopra, Ashima; Chandran, Anu V; Marples, Peter G; Balcomb, Blake H; Fearon, Daren; von Delft, Frank; Arnold, Eddy

The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice.

抗病毒药物 BDGR-49 可保护小鼠免受致命的嗜神经性委内瑞拉马脑炎病毒鼻内感染

Williams Evan P, Xue Yi, Vogel Peter, Yang Dong, Ponce-Flores Alejandro, Li Xiaoyu, Ogorek Tyler J, Saini Manisha, Iulek Jorge, Ruiz Francesc Xavier, Arnold Eddy, Golden Jennifer E, Meibohm Bernd, Jonsson Colleen B

Crystallographic fragment screening of the dengue virus polymerase reveals multiple binding sites for the development of non-nucleoside antiflavivirals

登革病毒聚合酶晶体学片段筛选揭示了多个可用于开发非核苷类抗黄病毒药物的结合位点

Saini, Manisha; Aschenbrenner, Jasmin C; Ruiz, Francesc Xavier; Chopra, Ashima; Chandran, Anu V; Marples, Peter G; Balcomb, Blake H; Fearon, Daren; von Delft, Frank; Arnold, Eddy

Structures, functions and adaptations of the human LINE-1 ORF2 protein

人类LINE-1 ORF2蛋白的结构、功能和适应性

Baldwin, Eric T; van Eeuwen, Trevor; Hoyos, David; Zalevsky, Arthur; Tchesnokov, Egor P; Sánchez, Roberto; Miller, Bryant D; Di Stefano, Luciano H; Ruiz, Francesc Xavier; Hancock, Matthew; Işik, Esin; Mendez-Dorantes, Carlos; Walpole, Thomas; Nichols, Charles; Wan, Paul; Riento, Kirsi; Halls-Kass, Rowan; Augustin, Martin; Lammens, Alfred; Jestel, Anja; Upla, Paula; Xibinaku, Kera; Congreve, Samantha; Hennink, Maximiliaan; Rogala, Kacper B; Schneider, Anna M; Fairman, Jennifer E; Christensen, Shawn M; Desrosiers, Brian; Bisacchi, Gregory S; Saunders, Oliver L; Hafeez, Nafeeza; Miao, Wenyan; Kapeller, Rosana; Zaller, Dennis M; Sali, Andrej; Weichenrieder, Oliver; Burns, Kathleen H; Götte, Matthias; Rout, Michael P; Arnold, Eddy; Greenbaum, Benjamin D; Romero, Donna L; LaCava, John; Taylor, Martin S

Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

设计一种在小鼠模型中具有抗病毒功效的SARS-CoV-2木瓜蛋白酶样蛋白酶抑制剂

Tan, Bin; Zhang, Xiaoming; Ansari, Ahmadullah; Jadhav, Prakash; Tan, Haozhou; Li, Kan; Chopra, Ashima; Ford, Alexandra; Chi, Xiang; Ruiz, Francesc Xavier; Arnold, Eddy; Deng, Xufang; Wang, Jun

Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure

动力学协同进化模型预测了在药物选择压力下HIV-1耐药突变的出现时间。

Biswas, Avik; Choudhuri, Indrani; Arnold, Eddy; Lyumkis, Dmitry; Haldane, Allan; Levy, Ronald M

Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors.

基于结构的共价SARS-CoV-2木瓜蛋白酶样蛋白酶抑制剂设计

Tan Bin, Liang Xueying, Ansari Ahmadullah, Jadhav Prakash, Tan Haozhou, Li Kan, Ruiz Francesc Xavier, Arnold Eddy, Deng Xufang, Wang Jun

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

发现含哌嗪磺酰基的二芳基嘧啶衍生物是强效的HIV-1非核苷类逆转录酶抑制剂

Jiang, Xiangyi; Huang, Boshi; Rumrill, Shawn; Pople, David; Zalloum, Waleed A; Kang, Dongwei; Zhao, Fabao; Ji, Xiangkai; Gao, Zhen; Hu, Lide; Wang, Zhao; Xie, Minghui; De Clercq, Erik; Ruiz, Francesc X; Arnold, Eddy; Pannecouque, Christophe; Liu, Xinyong; Zhan, Peng

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

设计一种在小鼠模型中具有抗病毒功效的SARS-CoV-2木瓜蛋白酶样蛋白酶抑制剂

Tan, Bin; Zhang, Xiaoming; Ansari, Ahmadullah; Jadhav, Prakash; Tan, Haozhou; Li, Kan; Chopra, Ashima; Ford, Alexandra; Chi, Xiang; Ruiz, Francesc Xavier; Arnold, Eddy; Deng, Xufang; Wang, Jun