日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

内质网小管的空间蛋白质组学分析揭示了CLMN的存在,CLMN是一种位于黏着斑的内质网-肌动蛋白连接蛋白,可促进细胞迁移。

Holly Merta,Kaitlynn Gov,Tadamoto Isogai,Blessy Paul,Achinta Sannigrahi,Arun Radhakrishnan,Gaudenz Danuser,W Mike Henne

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER

DGAT2 抑制可阻止 SREBP-1 裂解并通过增加内质网中的磷脂酰乙醇胺来改善肝脂肪变性

Shunxing Rong, Mingfeng Xia, Goncalo Vale, Simeng Wang, Chai-Wan Kim, Shili Li, Jeffrey G McDonald, Arun Radhakrishnan, Jay D Horton

Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis

开发单克隆抗体来研究 MARCH6,这是一种调节控制脂质稳态的蛋白质的 E3 连接酶

Shimeng Xu, Linda Donnelly, Daniel L Kober, Myra Mak, Arun Radhakrishnan

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

一种涉及 ACAT 和 SREBPs 的协同机制,通过该机制,氧固醇消耗可利用的胆固醇,以限制微生物感染

David B Heisler #, Kristen A Johnson #, Duo H Ma, Maikke B Ohlson, Lishu Zhang, Michelle Tran, Chase D Corley, Michael E Abrams, Jeffrey G McDonald, John W Schoggins, Neal M Alto, Arun Radhakrishnan

Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing

肩胛结构突出了交织的管腔环旋转在胆固醇感应中的关键作用

Daniel L Kober, Arun Radhakrishnan, Joseph L Goldstein, Michael S Brown, Lindsay D Clark, Xiao-Chen Bai, Daniel M Rosenbaum

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

补丁 1 降低了胆固醇在膜外叶的可及性

Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi

The use of anthrolysin O and ostreolysin A to study cholesterol in cell membranes

使用 anthrolysin O 和 ostreolysin A 研究细胞膜中的胆固醇

Kristen A Johnson, Arun Radhakrishnan

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

胆固醇稳定肝细胞中的TAZ以促进实验性非酒精性脂肪性肝炎

Xiaobo Wang, Bishuang Cai, Xiaoming Yang, Oluwatoni O Sonubi, Ze Zheng, Rajasekhar Ramakrishnan, Hongxue Shi, Luca Valenti, Utpal B Pajvani, Jaspreet Sandhu, Rodney E Infante, Arun Radhakrishnan, Douglas F Covey, Kun-Liang Guan, Jochen Buck, Lonny R Levin, Peter Tontonoz, Robert F Schwabe, Ira Tabas

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol

氧固醇通过调动细胞表面可及的胆固醇提供对细菌感染的先天免疫

Michael E Abrams #, Kristen A Johnson #, Sofya S Perelman, Li-Shu Zhang, Shreya Endapally, Katrina B Mar, Bonne M Thompson, Jeffrey G McDonald, John W Schoggins, Arun Radhakrishnan, Neal M Alto

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

质膜中鞘磷脂两种构象的分子鉴别

Shreya Endapally ,Donna Frias ,Magdalena Grzemska ,Austin Gay ,Diana R Tomchick ,Arun Radhakrishnan