日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

分化良好的胃肠胰神经内分泌肿瘤的肿瘤间谱系多样性和免疫抑制转录程序

Samantha E Hoffman, Todd W Dowrey, Carlos Villacorta Martin, Kevin Bi, Breanna Titchen, Shreya Johri, Laura DelloStritto, Miraj Patel, Colin Mackichan, Stephanie Inga, Judy Chen, Grace Grimaldi, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Jason Yeung, Asaf Rotem, Ewa Sicinska, Erin Shannon, Thomas Cla

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

微环境驱动胰腺癌细胞的状态、可塑性和药物反应

Srivatsan Raghavan ,Peter S Winter ,Andrew W Navia ,Hannah L Williams ,Alan DenAdel ,Kristen E Lowder ,Jennyfer Galvez-Reyes ,Radha L Kalekar ,Nolawit Mulugeta ,Kevin S Kapner ,Manisha S Raghavan ,Ashir A Borah ,Nuo Liu ,Sara A Väyrynen ,Andressa Dias Costa ,Raymond W S Ng ,Junning Wang ,Emma K Hill ,Dorisanne Y Ragon ,Lauren K Brais ,Alex M Jaeger ,Liam F Spurr ,Yvonne Y Li ,Andrew D Cherniack ,Matthew A Booker ,Elizabeth F Cohen ,Michael Y Tolstorukov ,Isaac Wakiro ,Asaf Rotem ,Bruce E Johnson ,James M McFarland ,Ewa T Sicinska ,Tyler E Jacks ,Ryan J Sullivan ,Geoffrey I Shapiro ,Thomas E Clancy ,Kimberly Perez ,Douglas A Rubinson ,Kimmie Ng ,James M Cleary ,Lorin Crawford ,Scott R Manalis ,Jonathan A Nowak ,Brian M Wolpin ,William C Hahn ,Andrew J Aguirre ,Alex K Shalek

Spatially organized multicellular immune hubs in human colorectal cancer

人类结直肠癌中空间组织化的多细胞免疫中心

Karin Pelka ,Matan Hofree ,Jonathan H Chen ,Siranush Sarkizova ,Joshua D Pirl ,Vjola Jorgji ,Alborz Bejnood ,Danielle Dionne ,William H Ge ,Katherine H Xu ,Sherry X Chao ,Daniel R Zollinger ,David J Lieb ,Jason W Reeves ,Christopher A Fuhrman ,Margaret L Hoang ,Toni Delorey ,Lan T Nguyen ,Julia Waldman ,Max Klapholz ,Isaac Wakiro ,Ofir Cohen ,Julian Albers ,Christopher S Smillie ,Michael S Cuoco ,Jingyi Wu ,Mei-Ju Su ,Jason Yeung ,Brinda Vijaykumar ,Angela M Magnuson ,Natasha Asinovski ,Tabea Moll ,Max N Goder-Reiser ,Anise S Applebaum ,Lauren K Brais ,Laura K DelloStritto ,Sarah L Denning ,Susannah T Phillips ,Emma K Hill ,Julia K Meehan ,Dennie T Frederick ,Tatyana Sharova ,Abhay Kanodia ,Ellen Z Todres ,Judit Jané-Valbuena ,Moshe Biton ,Benjamin Izar ,Conner D Lambden ,Thomas E Clancy ,Ronald Bleday ,Nelya Melnitchouk ,Jennifer Irani ,Hiroko Kunitake ,David L Berger ,Amitabh Srivastava ,Jason L Hornick ,Shuji Ogino ,Asaf Rotem ,Sébastien Vigneau ,Bruce E Johnson ,Ryan B Corcoran ,Arlene H Sharpe ,Vijay K Kuchroo ,Kimmie Ng ,Marios Giannakis ,Linda T Nieman ,Genevieve M Boland ,Andrew J Aguirre ,Ana C Anderson ,Orit Rozenblatt-Rosen ,Aviv Regev ,Nir Hacohen

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

在患者模型中,多模态混合 Perturb-CITE-seq 筛选揭示了癌症免疫逃逸的机制

Chris J Frangieh # ,Johannes C Melms # ,Pratiksha I Thakore # ,Kathryn R Geiger-Schuller # ,Patricia Ho ,Adrienne M Luoma ,Brian Cleary ,Livnat Jerby-Arnon ,Shruti Malu ,Michael S Cuoco ,Maryann Zhao ,Casey R Ager ,Meri Rogava ,Lila Hovey ,Asaf Rotem ,Chantale Bernatchez ,Kai W Wucherpfennig ,Bruce E Johnson ,Orit Rozenblatt-Rosen ,Dirk Schadendorf ,Aviv Regev ,Benjamin Izar

A single-cell landscape of high-grade serous ovarian cancer

高级别浆液性卵巢癌的单细胞图谱

Benjamin Izar # ,Itay Tirosh # ,Elizabeth H Stover # ,Isaac Wakiro ,Michael S Cuoco ,Idan Alter ,Christopher Rodman ,Rachel Leeson ,Mei-Ju Su ,Parin Shah ,Marcin Iwanicki ,Sarah R Walker ,Abhay Kanodia ,Johannes C Melms ,Shaolin Mei ,Jia-Ren Lin ,Caroline B M Porter ,Michal Slyper ,Julia Waldman ,Livnat Jerby-Arnon ,Orr Ashenberg ,Titus J Brinker ,Caitlin Mills ,Meri Rogava ,Sébastien Vigneau ,Peter K Sorger ,Levi A Garraway ,Panagiotis A Konstantinopoulos ,Joyce F Liu ,Ursula Matulonis ,Bruce E Johnson ,Orit Rozenblatt-Rosen ,Asaf Rotem ,Aviv Regev

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

用于新鲜和冷冻人类肿瘤的单细胞和单核RNA测序工具箱

Michal Slyper # ,Caroline B M Porter # ,Orr Ashenberg # ,Julia Waldman ,Eugene Drokhlyansky ,Isaac Wakiro ,Christopher Smillie ,Gabriela Smith-Rosario ,Jingyi Wu ,Danielle Dionne ,Sébastien Vigneau ,Judit Jané-Valbuena ,Timothy L Tickle ,Sara Napolitano ,Mei-Ju Su ,Anand G Patel ,Asa Karlstrom ,Simon Gritsch ,Masashi Nomura ,Avinash Waghray ,Satyen H Gohil ,Alexander M Tsankov ,Livnat Jerby-Arnon ,Ofir Cohen ,Johanna Klughammer ,Yanay Rosen ,Joshua Gould ,Lan Nguyen ,Matan Hofree ,Peter J Tramontozzi ,Bo Li ,Catherine J Wu ,Benjamin Izar ,Rizwan Haq ,F Stephen Hodi ,Charles H Yoon ,Aaron N Hata ,Suzanne J Baker ,Mario L Suvà ,Raphael Bueno ,Elizabeth H Stover ,Michael R Clay ,Michael A Dyer ,Natalie B Collins ,Ursula A Matulonis ,Nikhil Wagle ,Bruce E Johnson ,Asaf Rotem ,Orit Rozenblatt-Rosen ,Aviv Regev

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

癌细胞程序促进T细胞排斥和对检查点阻断的耐药性

Livnat Jerby-Arnon ,Parin Shah ,Michael S Cuoco ,Christopher Rodman ,Mei-Ju Su ,Johannes C Melms ,Rachel Leeson ,Abhay Kanodia ,Shaolin Mei ,Jia-Ren Lin ,Shu Wang ,Bokang Rabasha ,David Liu ,Gao Zhang ,Claire Margolais ,Orr Ashenberg ,Patrick A Ott ,Elizabeth I Buchbinder ,Rizwan Haq ,F Stephen Hodi ,Genevieve M Boland ,Ryan J Sullivan ,Dennie T Frederick ,Benchun Miao ,Tabea Moll ,Keith T Flaherty ,Meenhard Herlyn ,Russell W Jenkins ,Rohit Thummalapalli ,Monika S Kowalczyk ,Israel Cañadas ,Bastian Schilling ,Adam N R Cartwright ,Adrienne M Luoma ,Shruti Malu ,Patrick Hwu ,Chantale Bernatchez ,Marie-Andrée Forget ,David A Barbie ,Alex K Shalek ,Itay Tirosh ,Peter K Sorger ,Kai Wucherpfennig ,Eliezer M Van Allen ,Dirk Schadendorf ,Bruce E Johnson ,Asaf Rotem ,Orit Rozenblatt-Rosen ,Levi A Garraway ,Charles H Yoon ,Benjamin Izar ,Aviv Regev

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

利用类器官肿瘤球体进行PD-1阻断的体外分析

Russell W Jenkins,Amir R Aref,Patrick H Lizotte,Elena Ivanova,Susanna Stinson,Chensheng W Zhou,Michaela Bowden,Jiehui Deng,Hongye Liu ,Diana Miao,Meng Xiao He ,William Walker,Gao Zhang,Tian Tian,Chaoran Cheng,Zhi Wei,Sangeetha Palakurthi,Mark Bittinger,Hans Vitzthum,Jong Wook Kim,Ashley Merlino,Max Quinn,Chandrasekar Venkataramani,Joshua A Kaplan,Andrew Portell,Prafulla C Gokhale,Bart Phillips,Alicia Smart,Asaf Rotem,Robert E Jones,Lauren Keogh,Maria Anguiano,Lance Stapleton,Zhiheng Jia,Michal Barzily-Rokni,Israel Cañadas,Tran C Thai,Marc R Hammond,Raven Vlahos,Eric S Wang,Hua Zhang,Shuai Li,Glenn J Hanna,Wei Huang,Mai P Hoang,Adriano Piris,Jean-Pierre Eliane,Anat O Stemmer-Rachamimov,Lisa Cameron,Mei-Ju Su,Parin Shah,Benjamin Izar,Manisha Thakuria,Nicole R LeBoeuf,Guilherme Rabinowits,Viswanath Gunda,Sareh Parangi,James M Cleary,Brian C Miller,Shunsuke Kitajima,Rohit Thummalapalli,Benchun Miao,Thanh U Barbie,Vivek Sivathanu,Joshua Wong,William G Richards , Raphael Bueno , Charles H Yoon,Juan Miret,Meenhard Herlyn,Levi A Garraway,Eliezer M Van Allen,Gordon J Freeman,Paul T Kirschmeier,Jochen H Lorch,Patrick A Ott,F Stephen Hodi,Keith T Flaherty,Roger D Kamm  ,Genevieve M Boland,Kwok-Kin Wong,David Dornan , Cloud Peter Paweletz ,David A Barbie

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

基因组规模鉴定乳腺细胞转化过程中介导炎症网络的转录因子

Zhe Ji, Lizhi He, Asaf Rotem, Andreas Janzer, Christine S Cheng, Aviv Regev, Kevin Struhl

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state

黑色素瘤细胞通过可逆诱导缓慢分裂的去分化状态对 RAF 抑制产生适应性抵抗

Mohammad Fallahi-Sichani, Verena Becker, Benjamin Izar, Gregory J Baker, Jia-Ren Lin, Sarah A Boswell, Parin Shah, Asaf Rotem, Levi A Garraway, Peter K Sorger