日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

一项全基因组基因-睡眠相互作用研究在732,564名参与者中发现了新的脂质基因位点

Noordam, Raymond; Wang, Wenyi; Nagarajan, Pavithra; Wang, Heming; Brown, Michael R; Bentley, Amy R; Hui, Qin; Kraja, Aldi T; Morrison, John L; O'Connel, Jeffrey R; Lee, Songmi; Schwander, Karen; Bartz, Traci M; de Las Fuentes, Lisa; Feitosa, Mary F; Guo, Xiuqing; Hanfei, Xu; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Lefevre, Christophe; Mangino, Massimo; Milaneschi, Yuri; van der Most, Peter J; Pacheco, Natasha L; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Sun, Quan; Tabara, Yasuharu; Vojinovic, Dina; Wang, Yujie; Weiss, Stefan; Yang, Qian; Zhao, Wei; Zhu, Wanying; Ansari, Md Abu Yusuf; Aschard, Hugues; Anugu, Pramod; Assimes, Themistocles L; Attia, John; Baker, Laura D; Ballantyne, Christie; Bazzano, Lydia; Boerwinkle, Eric; Cade, Brain; Chen, Hung-Hsin; Chen, Wei; Ida Chen, Yii-Der; Chen, Zekai; Cho, Kelly; De Anda-Duran, Ileana; Dimitrov, Latchezar; Do, Anh; Edwards, Todd; Faquih, Tariq; Hingorani, Aroon; Fisher-Hoch, Susan P; Gaziano, J Michael; Gharib, Sina A; Giri, Ayush; Ghanbari, Mohsen; Grabe, Hans Jörgen; Graff, Mariaelisa; Charles Gu, C; He, Jiang; Heikkinen, Sami; Hixson, James; Ho, Yuk-Lam; Hood, Michelle M; Houghton, Serena C; Karvonen-Gutierrez, Carrie A; Kawaguchi, Takahisa; Kilpeläinen, Tuomas O; Komulainen, Pirjo; Lin, Henry J; Linchangco, Gregorio V Jr; Luik, Annemarie I; Ma, Jintao; Meigs, James B; McCormick, Joseph B; Menni, Cristina; Nolte, Ilja M; Norris, Jill M; Petty, Lauren E; Polikowsky, Hannah G; Raffield, Laura M; Rich, Stephen S; Riha, Renata L; Russ, Thomas C; Ruiz-Narvaez, Edward A; Sitlani, Colleen M; Smith, Jennifer A; Snieder, Harold; Sofer, Tamar; Shen, Botong; Tang, Jingxian; Taylor, Kent D; Teder-Laving, Maris; Triatin, Rima; Tsai, Michael Y; Völzke, Henry; Westerman, Kenneth E; Xia, Rui; Yao, Jie; Young, Kristin L; Zhang, Ruiyuan; Zonderman, Alan B; Zhu, Xiaofeng; Below, Jennifer E; Cox, Simon R; Evans, Michelle; Fornage, Myriam; Fox, Ervin R; Franceschini, Nora; Harlow, Sioban D; Holliday, Elizabeth; Ikram, M Arfan; Kelly, Tanika; Lakka, Timo A; Lawlor, Deborah A; Li, Changwei; Liu, Ching-Ti; Mägi, Reedik; Manning, Alisa K; Matsuda, Fumihiko; Morrison, Alanna C; Nauck, Matthias; North, Kari E; Penninx, Brenda Wjh; Province, Michael A; Psaty, Bruce M; Rotter, Jerome I; Spector, Tim D; Wagenknecht, Lynne E; van Dijk, Ko Willems; Jaquish, Cashell E; Wilson, Peter Wf; Peyser, Patricia A; Munroe, Patricia B; de Vries, Paul S; Gauderman, W James; Sun, Yan V; Chen, Han; Miller, Clint L; Winkler, Thomas W; Rao, Dabeeru C; Redline, Susan; van Heemst, Diana

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals

超过48万名个体中基因与睡眠时长对血糖特征的交互作用

Wang, Heming; Nagarajan, Pavithra; Miller, Clint L; Bentley, Amy R; Noordam, Raymond; Westerman, Kenneth E; Brown, Michael R; Kraja, Aldi T; O'Connell, Jeffrey R; Schwander, Karen; Li, Changwei; Sanghvi, Mihir M; Song, Yipei; Bartz, Traci M; Braunack-Mayer, Vincent; Chen, Ling; Du, Jiawen; Dunca, Diana; Feitosa, Mary F; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Highland, Heather M; Huang, Zhijie; Kang, Changhoon; Lakka, Timo A; Lefevre, Christophe; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Missikpode, Celestin; Morrison, John L; Palmer, Nicholette D; Richmond, Anne; Shahisavandi, Mina; Tang, Jingxian; van der Most, Peter J; Weiss, Stefan; Yu, Chenglong; Zhu, Wanying; Ansari, Md Abu Yusuf; Anugu, Pramod; Aschard, Hugues; Ashok, Kaavya; Attia, John R; Bazzano, Lydia A; Cade, Brian E; Campbell, Archie; Dimitrov, Latchezar M; Do, Anh; Faquih, Tariq; FinesilverSmith, Sandy L; Fisher-Hoch, Susan P; Fretts, Amanda M; Gharib, Sina A; Goodarzi, Mark O; Graff, Mariaelisa; Gu, Charles; Hanson, Paul; He, Jiang; Heikkinen, Sami; Hixson, James; Hsu, Sarah; Kähönen, Mika; Kho, Minjung; Kim, Hyunju; Komulainen, Pirjo; Launer, Lenore J; Lemaitre, Rozenn N; McNeil, John J; McCormick, Joseph B; Nolte, Ilja M; Raffield, Laura M; Raitakari, Olli T; Ramírez, Julia; Riha, Renata L; Risch, Martin; Risch, Lorenz; Russ, Tom C; Sarnowski, Chloé; Schram, Miranda T; Scott, Rodney J; Sofer, Tamar; Sun, Quan; Völker, Uwe; Völzke, Henry; Wang, Yujie; van Dijk, Ko Willems; Wood, Alexis C; Young, Kristin L; Zhang, Ruiyuan; Zhu, Xiaofeng; Below, Jennifer E; Conen, David; Cox, Simon R; Fox, Ervin R; Franceschini, Nora; Ghanbari, Mohsen; Grabe, Hans Jörgen; Gudnason, Vilmundur; Hayward, Caroline; Holliday, Elizabeth G; Jaquish, Cashell E; Lacaze, Paul; Lee, Seunggeun; Lehtimäki, Terho; Liu, Ching-Ti; Morrison, Alanna C; North, Kari E; Peyser, Patricia A; Province, Michael A; Psaty, Bruce M; Rauramaa, Rainer; Rosendaal, Frits R; Rotter, Jerome I; Snieder, Harold; Wagenknecht, Lynne E; Wareham, Nicholas J; Giri, Ayush; Kelly, Tanika N; Munroe, Patricia B; Gauderman, James; Winkler, Thomas W; de Vries, Paul S; Rao, Dabeeru C; Manning, Alisa K; Chen, Han; de Las Fuentes, Lisa; Redline, Susan; Meigs, James B

Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics

利用多性状遗传学识别慢性阻塞性肺疾病亚型

Ziyatdinov, Andrey; Hobbs, Brian D; Kanaan-Izquierdo, Samir; Moll, Matthew; Sakornsakolpat, Phuwanat; Shrine, Nick; Chen, Jing; Song, Kijoung; Bowler, Russell P; Castaldi, Peter J; Tobin, Martin D; Kraft, Peter; Silverman, Edwin K; Julienne, Hanna; Cho, Michael H; Aschard, Hugues

The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals

环境对健康人类肠道微生物群中细菌共丰度的影响

Boetto, Christophe; Romero, Violeta Basten; Henches, Léo; Frouin, Arthur; Auvergne, Antoine; Patin, Etienne; Bredon, Marius; Kennedy, Sean P; Duffy, Darragh; Quintana-Murci, Lluis; Sokol, Harry; Aschard, Hugues

Refinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions

对已发表的基因-体力活动相互作用影响高密度脂蛋白胆固醇的研究进行完善:性别和脂蛋白亚组分的作用

Westerman, Kenneth E; Kilpeläinen, Tuomas O; Sevilla-Gonzalez, Magdalena; Connelly, Margery A; Wood, Alexis C; Tsai, Michael Y; Taylor, Kent D; Rich, Stephen S; Rotter, Jerome I; Otvos, James D; Bentley, Amy R; Mora, Samia; Aschard, Hugues; Rao, D C; Gu, Charles; Chasman, Daniel I; Manning, Alisa K

Pitfalls in performing genome-wide association studies on ratio traits

对比率性状进行全基因组关联研究的陷阱

McCaw, Zachary R; Dey, Rounak; Somineni, Hari; Amar, David; Mukherjee, Sumit; Sandor, Kaitlin; Karaletsos, Theofanis; Koller, Daphne; Aschard, Hugues; Smith, George Davey; MacArthur, Daniel; O'Dushlaine, Colm; Soare, Thomas W

Polygenic risk score prediction accuracy convergence

多基因风险评分预测准确性收敛

Henches, Léo; Kim, Jihye; Yang, Zhiyu; Rubinacci, Simone; Pires, Gabriel; Albiñana, Clara; Boetto, Christophe; Julienne, Hanna; Frouin, Arthur; Auvergne, Antoine; Suzuki, Yuka; Djebali, Sarah; Delaneau, Olivier; Ganna, Andrea; Vilhjálmsson, Bjarni; Privé, Florian; Aschard, Hugues

Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids

结合SNP与心理社会因素相互作用的多民族全基因组关联分析,发现了血清脂质的新基因位点

Bentley, Amy R; Brown, Michael R; Musani, Solomon K; Schwander, Karen L; Winkler, Thomas W; Sims, Mario; Kilpeläinen, Tuomas O; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Chai, Jin-Fang; Chitrala, Kumaraswamy Naidu; Franceschini, Nora; Graff, Mariaelisa; Guo, Xiuqing; Hartwig, Fernando P; Horimoto, Andrea R V R; Lim, Elise; Liu, Yongmei; Manning, Alisa K; Nolte, Ilja M; Noordam, Raymond; Richard, Melissa A; Smith, Albert V; Sung, Yun Ju; Vojinovic, Dina; Wang, Rujia; Wang, Yujie; Feitosa, Mary F; Harris, Sarah E; Lyytikäinen, Leo-Pekka; Pistis, Giorgio; Rauramaa, Rainer; van der Most, Peter J; Ware, Erin; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R; Arking, Dan E; Arnett, Donna K; Ballantyne, Christie; Boerwinkle, Eric; Chen, Yii-Der Ida; Daviglus, Martha L; de Las Fuentes, Lisa; de Vries, Paul S; Delaney, Joseph A C; Fretts, Amanda M; Ekunwe, Lynette; Faul, Jessica D; Gallo, Linda C; Heikkinen, Sami; Homuth, Georg; Ikram, M Arfan; Isasi, Carmen R; Jonas, Jost Bruno; Keltikangas-Järvinen, Liisa; Komulainen, Pirjo; Kraja, Aldi T; Krieger, Jose E; Launer, Lenore; Liu, Jianjun; Lohman, Kurt; Luik, Annemarie I; Manichaikul, Ani W; Marques-Vidal, Pedro; Milaneschi, Yuri; Mwasongwe, Stanford E; O'Connell, Jeffrey R; Rice, Kenneth; Rich, Stephen S; Schreiner, Pamela J; Schwettmann, Lars; Shikany, James M; Shu, Xiao-Ou; Smith, Jennifer A; Snieder, Harold; Sotoodehnia, Nona; Tai, E Shyong; Taylor, Kent D; Tinker, Lesley; Tsai, Michael Y; Uitterlinden, André G; van Duijn, Cornelia M; van Heemst, Diana; Waldenberger, Melanie; Wallace, Robert B; Wee, Hwee-Lin; Weir, David R; Wei, Wen-Bin; Willems van Dijk, Ko; Wilson, Gregory; Yao, Jie; Young, Kristin L; Zhang, Xiaoyu; Zhao, Wei; Zhu, Xiaofeng; Zonderman, Alan B; Deary, Ian J; Gieger, Christian; Grabe, Hans Jörgen; Lakka, Timo A; Lehtimäki, Terho; Oldehinkel, Albertine J; Preisig, Martin; Wang, Ya-Xing; Zheng, Wei; Evans, Michele K; Province, Michael; Gauderman, James; Gudnason, Vilmundur; Hartman, Catharina A; Horta, Bernardo L; Kardia, Sharon L R; Kooperberg, Charles; Liu, Ching-Ti; Mook-Kanamori, Dennis O; Penninx, Brenda Wjh; Pereira, Alexandre C; Peyser, Patricia A; Psaty, Bruce M; Rotter, Jerome I; Sim, Xueling; North, Kari E; Rao, Dabeeru C; Bierut, Laura; Miller, Clint L; Morrison, Alanna C; Rotimi, Charles N; Fornage, Myriam; Fox, Ervin R

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

一项针对来自不同人群的 811,405 名个体的大规模全基因组研究,探讨了基因-睡眠时长相互作用与血压之间的关系。

Nagarajan, Pavithra; Winkler, Thomas W; Bentley, Amy R; Miller, Clint L; Kraja, Aldi T; Schwander, Karen; Lee, Songmi; Wang, Wenyi; Brown, Michael R; Morrison, John L; Giri, Ayush; O'Connell, Jeffrey R; Bartz, Traci M; de Las Fuentes, Lisa; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Kho, Minjung; Lefevre, Christophe; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Shen, Botong; Stadler, Stefan; Sun, Quan; Tang, Jingxian; Thériault, Sébastien; van der Graaf, Adriaan; van der Most, Peter J; Wang, Yujie; Weiss, Stefan; Westerman, Kenneth E; Yang, Qian; Yasuharu, Tabara; Zhao, Wei; Zhu, Wanying; Altschul, Drew; Ansari, Md Abu Yusuf; Anugu, Pramod; Argoty-Pantoja, Anna D; Arzt, Michael; Aschard, Hugues; Attia, John R; Bazzanno, Lydia; Breyer, Max A; Brody, Jennifer A; Cade, Brian E; Chen, Hung-Hsin; Chen, Yii-Der Ida; Chen, Zekai; de Vries, Paul S; Dimitrov, Latchezar M; Do, Anh; Du, Jiawen; Dupont, Charles T; Edwards, Todd L; Evans, Michele K; Faquih, Tariq; Felix, Stephan B; Fisher-Hoch, Susan P; Floyd, James S; Graff, Mariaelisa; Gu, Charles; Gu, Dongfeng; Hairston, Kristen G; Hanley, Anthony J; Heid, Iris M; Heikkinen, Sami; Highland, Heather M; Hood, Michelle M; Kähönen, Mika; Karvonen-Gutierrez, Carrie A; Kawaguchi, Takahisa; Kazuya, Setoh; Kelly, Tanika N; Komulainen, Pirjo; Levy, Daniel; Lin, Henry J; Liu, Peter Y; Marques-Vidal, Pedro; McCormick, Joseph B; Mei, Hao; Meigs, James B; Menni, Cristina; Nam, Kisung; Nolte, Ilja M; Pacheco, Natasha L; Petty, Lauren E; Polikowsky, Hannah G; Province, Michael A; Psaty, Bruce M; Raffield, Laura M; Raitakari, Olli T; Rich, Stephen S; Riha, Renata L; Risch, Lorenz; Risch, Martin; Ruiz-Narvaez, Edward A; Scott, Rodney J; Sitlani, Colleen M; Smith, Jennifer A; Sofer, Tamar; Teder-Laving, Maris; Völker, Uwe; Vollenweider, Peter; Wang, Guanchao; Willems van Dijk, Ko; Wilson, Otis D; Xia, Rui; Yao, Jie; Young, Kristin L; Zhang, Ruiyuan; Zhu, Xiaofeng; Below, Jennifer E; Böger, Carsten A; Conen, David; Cox, Simon R; Dörr, Marcus; Feitosa, Mary F; Fox, Ervin R; Franceschini, Nora; Gharib, Sina A; Gudnason, Vilmundur; Harlow, Sioban D; He, Jiang; Holliday, Elizabeth G; Kutalik, Zoltan; Lakka, Timo A; Lawlor, Deborah A; Lee, Seunggeun; Lehtimäki, Terho; Li, Changwei; Liu, Ching-Ti; Mägi, Reedik; Matsuda, Fumihiko; Morrison, Alanna C; Penninx, Brenda Wjh; Peyser, Patricia A; Rotter, Jerome I; Snieder, Harold; Spector, Tim D; Wagenknecht, Lynne E; Wareham, Nicholas J; Zonderman, Alan B; North, Kari E; Fornage, Myriam; Hung, Adriana M; Manning, Alisa K; Gauderman, James; Chen, Han; Munroe, Patricia B; Rao, Dabeeru C; van Heemst, Diana; Redline, Susan; Noordam, Raymond; Wang, Heming

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

大规模基因-吸烟相互作用及精细定位研究在超过100万人中发现了多个新的血压基因位点

Zhang, Mengyu; Brown, Michael R; Bentley, Amy R; Winkler, Thomas W; Noordam, Raymond; Nagarajan, Pavithra; Guo, Bohong; Lee, Songmi; Schwander, Karen; Wang, Wenyi; Westerman, Kenneth; O'Connell, Jeffrey R; Ammous, Farah; Argoty-Pantoja, Anna D; Bartz, Traci M; Batini, Chiara; Boua, Palwende R; Cordell, Heather J; Díez-Ahijado, Laia; Dimitrov, Latchezar; Do, Anh N; Du, Jiawen; Feitosa, Mary F; Giri, Ayush; Giulianini, Franco; Gudmundsdottir, Valborg; Guo, Xiuqing; Harris, Sarah E; Hasbani, Natalie R; Herold, Janina M; Hikino, Keiko; Hofer, Edith; Hsu, Fang-Chi; Jackson, Anne U; Kho, Minjung; Kraja, Aldi T; Lyytikäinen, Leo-Pekka; Meirhaeghe, Aline; Muntaner, Manon; Nakatochi, Masahiro; Nardone, Giuseppe Giovanni; Nutile, Teresa; Palmer, Nicholette D; Pecori, Alessandro; Rao, Varun S; Rauramaa, Rainer; Sanghvi, Mihir M; Santin, Aurora; Shen, Botong; Stringham, Heather M; Takeuchi, Fumihiko; Tan, Ye An; Tang, Jingxian; Thériault, Sébastien; Trofimova, Olga; Trompet, Stella; van der Most, Peter J; Wang, Ya Xing; Wang, Zhe; Wang, Yujie; Ware, Erin B; Weiss, Stefan; Wickremasinghe, Ananda Rajitha; Yu, Chenglong; Zhu, Wanying; Ansari, Md Abu Yusuf; Anugu, Pramod; Banas, Bernhard; Barr, R Graham; Basnet, Til B; Boerwinkle, Eric; Böger, Carsten A; Breyer, Max; Broeckel, Ulrich; Bryant, Luke; Cade, Brian; Camarda, Silvia; Cennamo, Pasqualina; Checkley, William; Chee, Miao-Li; Chen, Guanjie; Coley, Kayesha; Collins, Stacey D; de Borst, Martin H; de Las Fuentes, Lisa; Deary, Ian J; Dupont, Charles T; Enzinger, Christian; Faquih, Tariq; Faul, Jessica D; Silva, Lilian Fernandes; Gauthier, Victoria; Gepner, Adam D; Gorski, Mathias; Grabe, Hans Jörgen; Graff, Mariaelisa; Gu, Charles C; He, Jiang; Heikkinen, Sami; Hidalgo, Bertha; Highland, Heather M; Hixson, James E; Hood, Michelle M; Hunt, Steven C; Irvin, Marguerite Ryan; Isono, Masato; Kähönen, Mika; Kardia, Sharon L R; Karvonen-Gutierrez, Carrie A; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kaufman, Joel D; Koistinen, Heikki A; Komulainen, Pirjo; Krämer, Bernhard K; Launer, Lenore J; Leonard, Hampton; Levy, Daniel; Liu, Jianjun; Marques-Vidal, Pedro; Martinez-Perez, Angel; Matsuda, Koichi; McNeil, John J; Milaneschi, Yuri; Miranda, J Jaime; Morrison, John L; Nalls, Michael; Ng, Maggie Cy; Nolte, Ilja M; Norris, Jill M; Oravilahti, Anniina; Patki, Amit; Petty, Lauren E; Peyser, Patricia A; Pianigiani, Giulia; Raffield, Laura M; Raitakari, Olli T; Ramsay, Michele; Rice, Ken M; Ridker, Paul M; Risch, Lorenz; Risch, Martin; Ruggiero, Daniela; Ruiz-Narvaez, Edward A; Russ, Tom C; Sabanayagam, Charumathi; Vaitinadin, Nataraja Sarma; Schmidt, Reinhold; Scott, Laura J; Singh, Surina; Sitlani, Colleen M; Smit, Roelof A J; Smith, Jennifer A; Sun, Quan; Tai, E Shyong; Taylor, Kent D; Tesolin, Paola; Tham, Yih Chung; Tinashe, Chikowore; van Dam, Rob M; Vaucher, Julien; Völker, Uwe; Wang, Chaolong; Wilson, Otis D; Wong, Tien-Yin; Xu, Jianzhao; Yamamoto, Ken; Yao, Jie; Yokota, Mitsuhiro; Young, Kristin L; Zimmermann, Martina E; Amouyel, Philippe; Below, Jennifer E; Bergmann, Sven; Bernabe-Ortiz, Antonio; Bierut, Laura; Boehnke, Michael; Bowden, Donald W; Brandenburg, Jean-Tristan; Chasman, Daniel I; Cheng, Ching-Yu; Ciullo, Marina; Concas, Maria Pina; Conen, David; Cox, Simon R; Dauchet, Luc; de Silva, Hithanadura Janaka; Dörr, Marcus; Edwards, Todd L; Fox, Ervin R; Franceschini, Nora; Freedman, Barry I; Girotto, Giorgia; Gudnason, Vilmundur; Harlow, Sioban D; Heid, Iris M; Hung, Adriana M; Ichihara, Sahoko; Jaquish, Cashell E; John, Catherine; Jonas, Jost B; Jukema, J Wouter; Kato, Norihiro; Keavney, Bernard D; Kelly, Tanika N; Laakso, Markku; Lacaze, Paul; Lakka, Timo; Lee, Seunggeun; Lehtimäki, Terho; Liu, Ching-Ti; Loos, Ruth J F; North, Kari E; Penninx, Brenda; Province, Michael A; Psaty, Bruce M; Redline, Susan; Rosendaal, Frits R; Rotimi, Charles N; Rotter, Jerome I; Sabater-Lleal, Maria; Schmidt, Helena; Sim, Xueling; Snieder, Harold; Spedicati, Beatrice; Stark, Klaus J; Terao, Chikashi; Wagenknecht, Lynne E; Weir, David R; Zhao, Wei; Zhu, Xiaofeng; Munroe, Patricia B; Sun, Yan V; Gauderman, James; Manning, Alisa K; Fornage, Myriam; Aschard, Hugues; Wang, Heming; de Vries, Paul S; Wang, Gao; Rao, Dabeeru C; Morrison, Alanna C; Chen, Han