日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KLHDC3 deficiency in mice reveals essential roles in development, survival, and adiposity via the DesCEND ubiquitin pathway

小鼠KLHDC3缺陷揭示了其通过DesCEND泛素通路在发育、存活和脂肪沉积中发挥的关键作用。

Paula Armina V Buco,Ashfaqul Hoque,Wilson Castillo-Tandazo,Alistair M Chalk,Monique F Smeets,Carl R Walkley

Insights into Graphene Nanostructures, Fabrication Techniques, Mechanical, and Functional Behavior Characterization

石墨烯纳米结构、制备技术、力学性能和功能行为表征的深入研究

Khadem, Ashfaqul Hoque; Diaz, Camili Brignoni; Lou, Lihua

Enhanced Expression of Mitochondrial Magmas Protein in Ovarian Carcinomas: Magmas Inhibition Facilitates Antitumour Effects, Signifying a Novel Approach for Ovarian Cancer Treatment

卵巢癌中线粒体Magmas蛋白表达增强:抑制Magmas蛋白可增强抗肿瘤作用,提示卵巢癌治疗的新策略

Ali Raza ,Ashfaqul Hoque ,Rodney Luwor ,Ruth M Escalona ,Jason Kelly ,Revati Sharma ,Fadi Charchar ,Simon Chu ,Mary K Short ,Paul T Jubinsky ,George Kannourakis ,Nuzhat Ahmed

AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates

通过无标记质谱法对 AMPK 磷酸化位点进行分析,揭示了大量受 mTORC1 调控的底物

William J Smiles #, Ashley J Ovens #, Dingyi Yu, Naomi X Y Ling, Andrea C Poblete Goycoolea, Kaitlin R Morrison, Emmanuel O Murphy, Astrid Glaser, Sophie F Monks O'Byrne, Scott Taylor, Alistair M Chalk, Carl R Walkley, Luke M McAloon, John W Scott, Bruce E Kemp, Ashfaqul Hoque, Christopher G Langend

N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

兴奋毒性期间神经元的 N 端变化揭示与突触功能障碍相关的蛋白水解事件以及神经保护的潜在靶点

S Sadia Ameen, Nane Griem-Krey, Antoine Dufour, M Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik F Draxler, Robert L Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S Lucet, Michael G Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bo

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

AMPKα2 特异性磷酸化开关控制溶酶体靶向激活

Kaitlin R Morrison, William J Smiles, Naomi X Y Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin R W Ngoei, Dingyi Yu, Lisa Murray-Segal, John W Scott, Sandra Galic, Bruce E Kemp, Janni Petersen, Jonathan S Oakhill

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

阻断 AMPK β1 肉豆蔻酰化可增强 AMPK 活性并保护小鼠免受高脂饮食引起的肥胖和肝脂肪变性

Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J Ovens, Gavin Tjin, Luke M McAloon, Dingyi Yu, Naomi X Y Ling, Matthew J Sanders, Jonathan S Oakhill, John W Scott, Gregory R Steinberg, Kim Loh, Bruce E Kemp, Kei Sakamoto, Sandra Galic

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

mTORC1 直接抑制 AMPK 促进营养应激下的细胞增殖

Naomi X Y Ling #, Adrian Kaczmarek #, Ashfaqul Hoque #, Elizabeth Davie #, Kevin R W Ngoei #, Kaitlin R Morrison, William J Smiles, Gabriella M Forte, Tingting Wang, Shervi Lie, Toby A Dite, Christopher G Langendorf, John W Scott, Jonathan S Oakhill, Janni Petersen

The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

eEF2 激酶诱导的 STAT3 失活通过 PKM2 磷酸化抑制肺癌细胞增殖

Min Xiao, Jianling Xie, Yu Wu, Genzhu Wang, Xin Qi, Zailiang Liu, Yuying Wang, Xuemin Wang, Ashfaqul Hoque, Jon Oakhill, Christopher G Proud, Jing Li

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

对 Ca2+ -钙调蛋白依赖性蛋白激酶激酶 2 (CaMKK2) 的 R311C 变体进行功能分析,发现其为一名双相情感障碍患者的新生突变

Naomi Xy Ling, Christopher G Langendorf, Ashfaqul Hoque, Sandra Galic, Kim Loh, Bruce E Kemp, Andrew L Gundlach, Jonathan S Oakhill, John W Scott