日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma

MT-125抑制非肌肉肌球蛋白IIA和IIB,延长胶质母细胞瘤患者的生存期。

Rajappa S Kenchappa ,Laszlo Radnai ,Erica J Young ,Natanael Zarco ,Li Lin ,Athanassios Dovas ,Christian T Meyer ,Ashley Haddock ,Alice Hall ,Katalin Toth ,Peter Canoll ,Naveen K H Nagaiah ,Gavin Rumbaugh ,Michael D Cameron ,Theodore M Kamenecka ,Patrick R Griffin ,Courtney A Miller ,Steven S Rosenfeld

Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence

胶质母细胞瘤对纺锤体抑制剂的耐药性取决于 STAT3 和治疗诱导的衰老

Natanael Zarco, Athanassios Dovas, Virginea de Araujo Farias, Naveen K H Nagaiah, Ashley Haddock, Peter A Sims, Dolores Hambardzumyan, Christian T Meyer, Peter Canoll, Steven S Rosenfeld, Rajappa S Kenchappa

Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

胶质母细胞瘤中,STAT3通过SRC和EGFR信号通路的联合激活而产生对有丝分裂驱动蛋白抑制剂的耐药性。

Rajappa S Kenchappa,Athanassios Dovas,Michael G Argenziano,Christian T Meyer,Lauren E Stopfer,Matei A Banu,Brianna Pereira,Jessica Griffith,Afroz Mohammad,Surabhi Talele,Ashley Haddock,Natanael Zarco,William Elmquist,Forest White,Vito Quaranta,Peter Sims,Peter Canoll,Steven S Rosenfeld