日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fasting and Caloric Restriction Activate an ADIOL-NHR-91-Kynurenine Pathway Signaling Axis to Promote Healthspan

禁食和热量限制激活 ADIOL-NHR-91-犬尿氨酸通路信号轴,从而促进健康寿命

Guijarro-Hernández, Ana; Yoo, Shinja; Lemieux, George A; Komatsu, Sena; Latiff, Abdullah Q; Patil, Rishika R; Ashrafi, Kaveh

Dietary restriction promotes neuronal resilience via ADIOL

饮食限制通过 ADIOL 促进神经元恢复力。

Guijarro-Hernández, Ana; Yoo, Shinja; Lemieux, George A; Komatsu, Sena; Latiff, Abdullah Q; Patil, Rishika R; Ashrafi, Kaveh

The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels

类固醇激素ADIOL通过降低神经链中犬尿酸水平来促进学习。

Lemieux, George A; Yoo, Shinja; Lin, Lin; Vohra, Mihir; Ashrafi, Kaveh

Identifying lipid particle sub-types in live Caenorhabditis elegans with two-photon fluorescence lifetime imaging

利用双光子荧光寿命成像技术鉴定活体秀丽隐杆线虫中的脂质颗粒亚型

Chen, Wei-Wen; Tang, Wenyu; Hamerton, Emily K; Kuo, Penelope X; Lemieux, George A; Ashrafi, Kaveh; Cicerone, Marcus T

Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity

利用光谱相干拉曼成像技术对秀丽隐杆线虫进行成像,揭示了脂质颗粒的多样性。

Chen, Wei-Wen; Lemieux, George A; Camp, Charles H Jr; Chang, Ta-Chau; Ashrafi, Kaveh; Cicerone, Marcus T

Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter

秀丽隐杆线虫中神经系统产生犬尿酸需要AAT-1转运蛋白。

Lin, Lin; Lemieux, George A; Enogieru, Osatohanmwen Jessica; Giacomini, Kathleen M; Ashrafi, Kaveh

Kynurenic acid accumulation underlies learning and memory impairment associated with aging

犬尿酸的积累是与衰老相关的学习和记忆障碍的根本原因。

Vohra, Mihir; Lemieux, George A; Lin, Lin; Ashrafi, Kaveh

The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite

饮食限制对学习的有益影响与它对寿命的影响截然不同,并且是通过消耗一种神经抑制代谢物来实现的。

Vohra, Mihir; Lemieux, George A; Lin, Lin; Ashrafi, Kaveh

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

环核苷酸磷酸二酯酶 4 (PDE4) 作为潜在驱虫药物靶点的表型、化学和功能表征

Long Thavy, Rojo-Arreola Liliana, Shi Da, El-Sakkary Nelly, Jarnagin Kurt, Rock Fernando, Meewan Maliwan, Rascón Alberto A Jr, Lin Lin, Cunningham Katherine A, Lemieux George A, Podust Larissa, Abagyan Ruben, Ashrafi Kaveh, McKerrow James H, Caffrey Conor R

Stressing about misplaced fat is a key to longevity

对多余脂肪的担忧是长寿的关键。

Lemieux, George A; Ashrafi, Kaveh