日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有体内口服疗效

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R

Correction to: Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells

更正:APOBEC3B 表达升高驱动 p53 缺陷细胞中类似 kataegic 的突变特征和复制应激相关的治疗脆弱性

Nikkilä, Jenni; Kumar, Rahul; Campbell, James; Brandsma, Inger; Pemberton, Helen N; Wallberg, Fredrik; Nagy, Kinga; Scheer, Ildikó; Vertessy, Beata G; Serebrenik, Artur A; Monni, Valentina; Harris, Reuben S; Pettitt, Stephen J; Ashworth, Alan; Lord, Christopher J

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2

CACHE挑战赛#3:靶向SARS-CoV-2的Nsp3宏结构域

Herasymenko, Oleksandra; Silva, Madhushika; Correy, Galen J; Abu-Saleh, Abd Al-Aziz A; Ackloo, Suzanne; Arrowsmith, Cheryl; Ashworth, Alan; Ban, Fuqiang; Beck, Hartmut; Bishop, Kevin P; Bohórquez, Hugo J; Bolotokova, Albina; Breznik, Marko; Chau, Irene; Chen, Yu; Cherkasov, Artem; Dehaen, Wim; Della Corte, Dennis; Denzinger, Katrin; Doering, Niklas P; Edfeldt, Kristina; Edwards, Aled; Fayne, Darren; Gentile, Francesco; Gibson, Elisa; Gokdemir, Ozan; Gunnarsson, Anders; Günther, Judith; Irwin, John J; Jensen, Jan Halborg; Harding, Rachel J; Hillisch, Alexander; Hoffer, Laurent; Hogner, Anders; Hutchinson, Ashley; Kandwal, Shubhangi; Karlova, Andrea; Koirala, Kushal; Kotelnikov, Sergei; Kozakov, Dima; Lee, Juyong; Lee, Soowon; Lessel, Uta; Liu, Sijie; Liu, Xuefeng; Loppnau, Peter; Meiler, Jens; Moretti, Rocco; Moroz, Yurii S; Muvva, Charuvaka; Oprea, Tudor I; Paige, Brooks; Pandit, Amit; Park, Keunwan; Poda, Gennady; Protopopov, Mykola V; Pütter, Vera; Ravichandran, Rahul; Rognan, Didier; Rosta, Edina; Sabnis, Yogesh; Scott, Thomas; Seitova, Almagul; Sharma, Purshotam; Sindt, François; Song, Minghu; Steinmann, Casper; Stevens, Rick; Talagayev, Valerij; Tararina, Valentyna V; Tarkhanova, Olga; Tingey, Damon; Trant, John F; Treleaven, Dakota; Tropsha, Alexander; Walters, Patrick; Wells, Jude; Westermaier, Yvonne; Wolber, Gerhard; Wortmann, Lars; Zheng, Shuangjia; Fraser, James S; Schapira, Matthieu

Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'

对来自三个近交系小鼠的假常染色体区域的序列比较分析表明,它是进化速度最快的“染色体”。

Kasahara, Takaoki; Mekada, Kazuyuki; Abe, Kuniya; Ashworth, Alan; Kato, Tadafumi

Identification of a Two-Gene Biomarker Correlated with Sensitivity to Combined PARP7 Inhibition and AHR Activation in Cancer Cells

鉴定与癌细胞对PARP7抑制和AHR激活联合治疗敏感性相关的双基因生物标志物

Gou, Xuxu; Chen, Huadong; Diolaiti, Morgan E; Ashworth, Alan

Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning.

基于形状片段连接和主动学习探索 SARS-CoV-2 宏结构域的结构-活性关系

Correy Galen J, Rachman Moira M, Togo Takaya, Gahbauer Stefan, Doruk Yagmur U, Stevens Maisie G V, Jaishankar Priyadarshini, Kelley Brian, Goldman Brian, Schmidt Molly, Kramer Trevor, Radchenko Dmytro S, Moroz Yurii S, Ashworth Alan, Riley Patrick, Shoichet Brian K, Renslo Adam R, Walters W Patrick, Fraser James S

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Structure-activity relationship studies on 2-thienylidene substituted 3-oxo-2,3-dihydrobenzofuran-7-carboxamides as poly (ADP-ribose) polymerase inhibitors

2-噻吩亚甲基取代的3-氧代-2,3-二氢苯并呋喃-7-甲酰胺作为聚(ADP-核糖)聚合酶抑制剂的构效关系研究

Salami, Abosede; Adiele, Ugochi; Coate, Griffin; Diolaiti, Morgan; Chen, Huadong; Lu, Junhao; Ashworth, Alan; Patil, Manisha; Fleishman, Joshua S; Ramaraju, Andhavaram; Patel, Akanksha; Patel, Himaxi; Patel, Ketankumar; Murakami, Megumi; Ambudkar, Suresh V; Talele, Tanaji T

AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid

AcrIF11 是一种强效的 CRISPR 特异性 ADP-核糖基转移酶,由噬菌体和质粒编码。

Chen, Daphne F; Roe, Leah T; Yuping, Li; Borges, Adair L; Zhang, Jenny Y; Babbar, Palak; Maji, Sourobh; Stevens, Maisie G V; Correy, Galen J; Diolaiti, Morgan E; Smith, Dominique H; Ashworth, Alan; Stroud, Robert M; Kelly, Mark J S; Bondy-Denomy, Joseph; Fraser, James S

Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold

发现一种新型[6-6-5-5-6]五环四氢环戊酞嗪酮作为有前景的PARP抑制剂骨架

Doruk, Yagmur U; Diolaiti, Morgan E; Ashworth, Alan; Talele, Tanaji T