日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIP4K2C: an emerging fulcrum for multiple diseases

PIP4K2C:多种疾病的新兴支点

Pozzetti, Luca; Mishra, Manjari; Einav, Shirit; Asquith, Christopher R M

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C 抑制可逆转 SARS-CoV-2 引起的自噬通量受损

Karim Marwah, Mishra Manjari, Lo Chieh-Wen, Saul Sirle, Cagirici Halise Busra, Gourdelier Manon, Ghita Luca, Ojha Amrita, Tran Do Hoang Nhu, Agrawal Aditi, McGraw Connor, East Michael P, Gammeltoft Karen Anbro, Sahoo Malaya Kumar, Mooney Nancie A, Johnson Gary L, Das Soumita, Leyssen Pieter, Neyts Johan, Chiu Winston, Cohen Courtney A, Bukh Jens, Gottwein Judith, Dye John M, Neff Norma, Jackson Peter K, Pinsky Benjamin A, Laitinen Tuomo, Pantsar Tatu, Poso Antti, Zanini Fabio, De Jonghe Steven, Asquith Christopher R M, Einav Shirit

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

利用定量构效关系发现和优化窄谱Tousled样激酶2 (TLK2) 抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Enhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy.

利用喹唑啉类双重治疗策略增强粘菌素对沙门氏菌感染的疗效

Lobertti Carlos A, Gizzi Fernán O, Magni Christian, Rial Analía, Chabalgoity José A, Yim Lucía, Blancato Víctor S, Asquith Christopher R M, García Véscovi Eleonora

Pentathiepins are an understudied molecular prism of biological activities

五硫杂环庚烷是一类尚未得到充分研究的生物活性分子棱镜

Pozzetti, Luca; Asquith, Christopher R M

Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles

利用监督式机器学习理解激酶抑制剂毒素载体谱

Bieberich, Andrew A; Asquith, Christopher R M

The Synthesis and Biological Applications of the 1,2,3-Dithiazole Scaffold

1,2,3-二噻唑骨架的合成及其生物学应用

Kalogirou, Andreas S; Oh, Hans J; Asquith, Christopher R M

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

利用定量构效关系发现和优化Tousled样激酶2(TLK2)的窄谱抑制剂

Asquith, Christopher R M; East, Michael P; Laitinen, Tuomo; Alamillo-Ferrer, Carla; Hartikainen, Erkka; Wells, Carrow I; Axtman, Alison D; Drewry, David H; Tizzard, Graham J; Poso, Antti; Willson, Timothy M; Johnson, Gary L

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

鉴定 4-苯胺基喹啉(唑)啉为细胞活性蛋白激酶新型 3 (PKN3) 抑制剂化学型

Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H

PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders

PIKfyve:一种用于治疗 COVID-19、癌症和神经退行性疾病的脂质激酶靶点

Huang, Pei-Tzu; Einav, Shirit; Asquith, Christopher R M