日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Negative allosteric modulation of α5-GABA(A) receptors engages dynamic cortical glutamatergic and GABAergic mechanisms underlying adaptive behavior in mice.

α5-GABA(A)受体的负变构调节激活了小鼠适应性行为背后的动态皮质谷氨酸能和GABA能机制。

Daher Fernanda, Fukushima Caio T, Ingebretsen Erik A, Bidlack Jean M, Atack John R, Popa Mariana O, Fogaça Manoela V

Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors

四氢吡唑并吡啶酮类化合物作为一类新型高效高选择性LIMK抑制剂

Baldwin, Alex G; Foley, David W; Jones, D Heulyn; Lee, Hyunah; Collins, Ross; Wahab, Ben; Pedder, Josephine H; Waters, Loren; Paine, Marie; Schino, Lauramariú; Feng, Gui Jie; Kariuki, Benson M; Elkins, Jonathan M; Atack, John R; Ward, Simon E

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.

MDI-114215 的发现:一种强效且选择性的 LIMK 抑制剂,可用于治疗脆性 X 综合征

Baldwin Alex G, Foley David W, Collins Ross, Lee Hyunah, Jones D Heulyn, Wahab Ben, Waters Loren, Pedder Josephine, Paine Marie, Feng Gui Jie, Privitera Lucia, Ashall-Kelly Alexander, Thomas Carys, Gillespie Jason A, Schino Lauramariú, Belelli Delia, Rocha Cecilia, Maussion Gilles, Krahn Andrea I, Durcan Thomas M, Elkins Jonathan M, Lambert Jeremy J, Atack John R, Ward Simon E

Basmisanil, an α5-GABA(A)R negative allosteric modulator, produces rapid and sustained antidepressant-like responses in male mice

Basmisanil 是一种 α5-GABA(A)R 负变构调节剂,可在雄性小鼠中产生快速且持续的抗抑郁样反应。

Daher, Fernanda; Villalobos, Narcy A; Hanley, Marcus; Atack, John R; Popa, Mariana O; Fogaça, Manoela V

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

酪氨酸121的移动暴露出一个配体结合口袋,该口袋将丝氨酸消旋酶的催化作用与ATP结合偶联起来。

Koulouris, Chloe R; Gardiner, Sian E; Harris, Tessa K; Elvers, Karen T; Mark Roe, S; Gillespie, Jason A; Ward, Simon E; Grubisha, Olivera; Nicholls, Robert A; Atack, John R; Bax, Benjamin D

multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated (18)F-fluorination

通过铜介导的 (18)F-氟化反应合成 [18F]氟马西尼的多患者剂量

Gendron, Thibault; Destro, Gianluca; Straathof, Natan J W; Sap, Jeroen B I; Guibbal, Florian; Vriamont, Charles; Caygill, Claire; Atack, John R; Watkins, Andrew J; Marshall, Christopher; Hueting, Rebekka; Warnier, Corentin; Gouverneur, Véronique; Tredwell, Matthew

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile

对新型AMPA受体正向变构调节剂MDI-222进行药理学表征,该调节剂具有更佳的安全性。

Ward, Simon E; Harries, Mark H; Aldegheri, Laura; Bradford, Andrea M; Ballini, Elisa; Dawson, Lee; Lacroix, Laurent; Pardoe, Joanne; Starr, Kathryn; Weil, Annette; Waters, Kerry; Atack, John R; Woolley, Marie

Conformational flexibility within the small domain of human serine racemase

人丝氨酸消旋酶小结构域内的构象灵活性

Koulouris, Chloe R; Bax, Benjamin D; Atack, John R; Roe, S Mark

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase

依布硒啉与人肌醇单磷酸酶Cys141结合的结晶和结构

Fenn, Gareth D; Waller-Evans, Helen; Atack, John R; Bax, Benjamin D

Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABA(A) Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys

证据表明,苯二氮卓类药物的镇静作用涉及意想不到的GABA(A)受体亚型:恒河猴的定量观察研究

Duke, Angela N; Meng, Zhiqiang; Platt, Donna M; Atack, John R; Dawson, Gerard R; Reynolds, David S; Tiruveedhula, V V N Phani Babu; Li, Guanguan; Stephen, Michael Rajesh; Sieghart, Werner; Cook, James M; Rowlett, James K