日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of AMG 133, a Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonist and Glucagon-Like Peptide 1 Receptor Agonist Antibody-Drug Conjugate for the Treatment of Obesity

发现 AMG 133,一种葡萄糖依赖性胰岛素促泌多肽受体拮抗剂和胰高血糖素样肽-1受体激动剂抗体-药物偶联物,用于治疗肥胖症

Wu, Bin; Falsey, James R; Netirojjanakul, Chawita; Herberich, Brad; Holder, Jerry Ryan; Sham, Kelvin; Aral, Jennifer; Forsythe, Neil; Walker, Kenneth W; Lu, Shu-Chen; Hager, Todd; Stanislaus, Shanaka; Komorowski, Renee; Atangan, Larissa; Achmatowicz, Michal; Romanini, Dante; Weeraratne, Dohan; Miranda, Les P; Véniant, Murielle M; Cheng, Yuan

A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings

在临床前和 I 期临床试验中,与 GLP-1 类似物偶联的 GIPR 拮抗剂可促进体重减轻并改善代谢指标。

Véniant, Murielle M; Lu, Shu-Chen; Atangan, Larissa; Komorowski, Renee; Stanislaus, Shanaka; Cheng, Yuan; Wu, Bin; Falsey, James R; Hager, Todd; Thomas, Veena A; Ambhaikar, Malhar; Sharpsten, Lucie; Zhu, Yineng; Kurra, Vamsi; Jeswani, Rohini; Oberoi, Rajneet K; Parnes, Jane R; Honarpour, Narimon; Neutel, Joel; Strande, Jennifer L

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

与 GLP-1 肽结合的 GIPR 拮抗剂抗体是双特异性分子,可减轻肥胖小鼠和猴子的体重

Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A Killion, Renee Komorowski, Yuan Cheng, Chawita Netirojjanakul, James R Falsey, Marina Stolina, Denise Dwyer, Clarence Hale, Shanaka Stanislaus, Todd Hager, Veena A Thomas, John M Harrold, David J Lloyd, Murielle M Véniant

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

慢性葡萄糖依赖性胰岛素促泌多肽受体 (GIPR) 激动作用使脂肪细胞 GIPR 活性降低,模仿功能性 GIPR 拮抗作用

Elizabeth A Killion, Michelle Chen, James R Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M Véniant, David J Lloyd

An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice

载脂蛋白A-I模拟肽抗体可生成类似高密度脂蛋白(HDL)的颗粒,并增加小鼠体内α-1 HDL亚组分。

Lu, Shu-Chen; Atangan, Larissa; Won Kim, Ki; Chen, Michelle M; Komorowski, Renee; Chu, Carolyn; Han, Joon; Hu, Sylvia; Gu, Wei; Véniant, Murielle; Wang, Minghan

An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium

视黄酸受体拮抗剂抑制人前列腺癌细胞生长的效果优于抑制正常前列腺上皮细胞生长的效果。

Keedwell, R G; Zhao, Y; Hammond, L A; Wen, K; Qin, S; Atangan, L I; Shurland, D-L; Wallace, D M A; Bird, R; Reitmair, A; Chandraratna, R A S; Brown, G