Atze T相关文献与解析，生知库 | 链接生命科学的每一步

Reverse transcription of HIV-1 2-LTR circle transcripts does frequently cause 3'-polypurine tract mutations implicated in dolutegravir resistance

HIV-1 2-LTR环状转录本的逆转录常常导致3'-多嘌呤序列突变，而这种突变与多替拉韦耐药性有关。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/jvi.00335-24

Dekker, José G; Klaver, Bep; Berkhout, Ben; Das, Atze T

HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

HIV 利用其 RNA 激活应激激酶 PKR，从而劫持细胞抗病毒机制，以促进 rev/tat mRNA 的剪接。

期刊:Cell and Bioscience

影响因子:6.2

doi:10.1186/s13578-023-00972-1

Namer, Lise Sarah; Harwig, Alex; Heynen, Stephan P; Das, Atze T; Berkhout, Ben; Kaempfer, Raymond

CRISPR-Cas attack of HIV-1 proviral DNA can cause unintended deletion of surrounding cellular DNA

CRISPR-Cas 攻击 HIV-1 前病毒 DNA 可导致周围细胞 DNA 意外删除

期刊:Journal of Virology

影响因子:4

doi:10.1128/jvi.01334-23

Ye Liu, Caroline S Binda, Ben Berkhout, Atze T Das

HIV-1 3'-Polypurine Tract Mutations Confer Dolutegravir Resistance by Switching to an Integration-Independent Replication Mechanism via 1-LTR Circles.

HIV-1 3'-多嘌呤序列突变通过 1-LTR 环状结构转变为整合非依赖性复制机制，从而赋予多替拉韦耐药性

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/jvi.00361-23

Dekker JosÃ© G, Klaver Bep, Berkhout Ben, Das Atze T

Mutations in the HIV-1 3'-Polypurine Tract Can Confer Dolutegravir Resistance

HIV-1 3'-多嘌呤序列的突变可导致多替拉韦耐药性。

期刊:Antimicrobial Agents and Chemotherapy

影响因子:4.5

doi:10.1128/AAC.01027-21

Dekker, José G; Klaver, Bep; Berkhout, Ben; Das, Atze T

Transient CRISPR-Cas Treatment Can Prevent Reactivation of HIV-1 Replication in a Latently Infected T-Cell Line

瞬时 CRISPR-Cas 治疗可以阻止潜伏感染的 T 细胞系中 HIV-1 复制的重新激活

期刊:Viruses-Basel

影响因子:3.8

doi:10.3390/v13122461

Ye Liu, Rienk E Jeeninga, Bep Klaver, Ben Berkhout, Atze T Das

Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA

利用CRISPR-Cas12a系统，仅使用单个crRNA即可在细胞培养中彻底清除所有感染性HIV病毒。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaa226

Gao, Zongliang; Fan, Minghui; Das, Atze T; Herrera-Carrillo, Elena; Berkhout, Ben

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

核输出途径对细胞质HIV-1 RNA转运机制和分布的影响

期刊:mBio

影响因子:4.7

doi:10.1128/mBio.01578-20

Chen, Jianbo; Umunnakwe, Chijioke; Sun, David Q; Nikolaitchik, Olga A; Pathak, Vinay K; Berkhout, Ben; Das, Atze T; Hu, Wei-Shau

CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA

CRISPR-Cas9 双 gRNA 攻击导致 HIV-1 前病毒 DNA 突变、切除和反转

期刊:Viruses-Basel

影响因子:3.8

doi:10.3390/v12030330

Caroline S Binda, Bep Klaver, Ben Berkhout, Atze T Das

Evaluation of the effect of RNA secondary structure on Cas13d-mediated target RNA cleavage

评估RNA二级结构对Cas13d介导的靶RNA切割的影响

Reverse transcription of HIV-1 2-LTR circle transcripts does frequently cause 3'-polypurine tract mutations implicated in dolutegravir resistance

HIV-1 2-LTR环状转录本的逆转录常常导致3'-多嘌呤序列突变，而这种突变与多替拉韦耐药性有关。

HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA

HIV 利用其 RNA 激活应激激酶 PKR，从而劫持细胞抗病毒机制，以促进 rev/tat mRNA 的剪接。

CRISPR-Cas attack of HIV-1 proviral DNA can cause unintended deletion of surrounding cellular DNA

CRISPR-Cas 攻击 HIV-1 前病毒 DNA 可导致周围细胞 DNA 意外删除

HIV-1 3'-Polypurine Tract Mutations Confer Dolutegravir Resistance by Switching to an Integration-Independent Replication Mechanism via 1-LTR Circles.

HIV-1 3'-多嘌呤序列突变通过 1-LTR 环状结构转变为整合非依赖性复制机制，从而赋予多替拉韦耐药性

Mutations in the HIV-1 3'-Polypurine Tract Can Confer Dolutegravir Resistance

HIV-1 3'-多嘌呤序列的突变可导致多替拉韦耐药性。

Transient CRISPR-Cas Treatment Can Prevent Reactivation of HIV-1 Replication in a Latently Infected T-Cell Line

瞬时 CRISPR-Cas 治疗可以阻止潜伏感染的 T 细胞系中 HIV-1 复制的重新激活

Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA

利用CRISPR-Cas12a系统，仅使用单个crRNA即可在细胞培养中彻底清除所有感染性HIV病毒。

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution

核输出途径对细胞质HIV-1 RNA转运机制和分布的影响

CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA

CRISPR-Cas9 双 gRNA 攻击导致 HIV-1 前病毒 DNA 突变、切除和反转