日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Astro-Versus Microglia-Enriched Transcriptomes from Aged Atxn2-CAG100-Knockin Mice Suggest Underlying Pathology of RNA Processing at Ribosomes, and Possibly at U-Bodies

来自老年 Atxn2-CAG100 敲入小鼠的星形胶质细胞与小胶质细胞富集转录组提示核糖体 RNA 加工的潜在病理,以及可能在 U 体中发生的病理。

Auburger, Georg; Kandi, Arvind Reddy; Vutukuri, Rajkumar; Almaguer-Mederos, Luis-Enrique; Gispert, Suzana; Sen, Nesli-Ece; Key, Jana

Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration

自藻类以来,对共济蛋白-2家族的生物信息学分析强调了其小亚型、大嵌合体以及人类外显子1B作为预防神经退行性疾病治疗靶点的重要性。

Auburger, Georg W J; Key, Jana; Gispert, Suzana; Lastres-Becker, Isabel; Almaguer-Mederos, Luis-Enrique; Bassa, Carole; Auburger, Antonius; Auburger, Georg; Arsovic, Aleksandar; Deller, Thomas; Sen, Nesli-Ece

Influence of ATXN2 intermediate CAG repeats, 9bp duplication and alternative splicing on SCA3 pathogenesis.

ATXN2 中间 CAG 重复序列、9bp 重复和选择性剪接对 SCA3 发病机制的影响

Lauerer Marilena, Faber Jennifer, Casadei Nicolas, Santana Magda M, Auburger Georg, Pogoda Michaela, Admard Jakob, Kaupp Lea, Kos Patricia Laura, Raposo Mafalda, Lima Manuela, de Almeida Luis Pereira, Garcia-Moreno Hector, Giunti Paola, de Vries Jeroen, van de Warrenburg Bart P, van Gaalen Judith, Grobe-Einsler Marcus, Koyak Berkan, Reetz Kathrin, Erdlenbruch Friedrich, Jacobi Heike, Infante Jon, Hengel Holger, Schöls Ludger, Klockgether Thomas, Rieß Olaf, Hübener-Schmid Jeannette

Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death but Restricts Spontaneous Mobility and Affects the Alternative Splicing Pathway

成年额叶皮层CamK2a+神经元中条件性ATXN2L敲除不会导致细胞死亡,但会限制自发迁移并影响选择性剪接途径。

Key, Jana; Almaguer-Mederos, Luis-Enrique; Kandi, Arvind Reddy; Fellenz, Meike; Gispert, Suzana; Köpf, Gabriele; Meierhofer, David; Deller, Thomas; Auburger, Georg

Multiomics approach identifies SERPINB1 as candidate biomarker for spinocerebellar ataxia type 2

多组学方法鉴定出SERPINB1是2型脊髓小脑性共济失调的候选生物标志物

Almaguer-Mederos, Luis E; Key, Jana; Sen, Nesli-Ece; Canet-Pons, Julia; Döring, Claudia; Meierhofer, David; Gispert-Sánchez, Suzana; Cuello-Almarales, Dany; Almaguer-Gotay, Dennis; Osorio-González, Lidia M; Aguilera-Rodríguez, Raúl; Medrano-Montero, Jacqueline; Auburger, Georg

Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production

基因敲除小鼠研究表明,线粒体CLPP肽酶和CLPX解折叠酶在内膜附近的基质凝聚体中发挥作用,作为蛋白质组装体中转录加工、翻译和血红素生成的快速应激反应。

Key, Jana; Gispert, Suzana; Auburger, Georg

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes

细菌ClpXP-ClpB家族富含RNA结合蛋白复合物

Auburger, Georg; Key, Jana; Gispert, Suzana

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

双相情感障碍多重家族携带精神疾病常见风险变异的负担更重

Andlauer, Till F M; Guzman-Parra, Jose; Streit, Fabian; Strohmaier, Jana; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J; Del Río Noriega, Francisco; Perez, Fermin Perez; Haro González, Jesus; Orozco Diaz, Guillermo; de Diego-Otero, Yolanda; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C; Treutlein, Jens; Witt, Stephanie H; Cichon, Sven; Kogevinas, Manolis; Rivas, Fabio; Mayoral, Fermín; Müller-Myhsok, Bertram; Forstner, Andreas J; Nöthen, Markus M; Rietschel, Marcella

Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families

多重家族中双相情感障碍1型和2型的临床和遗传差异

Guzman-Parra, Jose; Streit, Fabian; Forstner, Andreas J; Strohmaier, Jana; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J; Del Río Noriega, Francisco; Perez Perez, Fermin; Haro González, Jesus; Orozco Diaz, Guillermo; de Diego-Otero, Yolanda; Moreno-Kustner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C; Sirignano, Lea; Witt, Stephanie H; Cichon, Sven; Rivas, Fabio; Mayoral, Fermín; Nöthen, Markus M; Andlauer, Till F M; Rietschel, Marcella

Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families

对来自 27 个多发性双相情感障碍家族的 81 名个体进行全外显子组测序

Forstner, Andreas J; Fischer, Sascha B; Schenk, Lorena M; Strohmaier, Jana; Maaser-Hecker, Anna; Reinbold, Céline S; Sivalingam, Sugirthan; Hecker, Julian; Streit, Fabian; Degenhardt, Franziska; Witt, Stephanie H; Schumacher, Johannes; Thiele, Holger; Nürnberg, Peter; Guzman-Parra, José; Orozco Diaz, Guillermo; Auburger, Georg; Albus, Margot; Borrmann-Hassenbach, Margitta; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J; Del Río Noriega, Francisco; Perez Perez, Fermin; Haro González, Jesus; Rivas, Fabio; Mayoral, Fermin; Bauer, Michael; Pfennig, Andrea; Reif, Andreas; Herms, Stefan; Hoffmann, Per; Pirooznia, Mehdi; Goes, Fernando S; Rietschel, Marcella; Nöthen, Markus M; Cichon, Sven