日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulation.

舒沃度肽通过脑室周围器官发挥作用,激活与食欲调节相关的神经元区域。

Zimmermann Tina, Bleymehl Katherin, Haebel Peter, Perens Johanna, Roostalu Urmas, Hecksher-Sørensen Jacob, Doerr Jonas, Jarosch Sebastian, Lam Daniel, Klein Holger, Pekcec Anton, Chehimi Samar N, Crist Richard C, Reiner Benjamin C, Hayes Matthew R, Augustin Robert

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

肝星状细胞通过R-spondin 3控制肝脏分区、大小和功能。

Atsushi Sugimoto # ,Yoshinobu Saito # ,Guanxiong Wang # ,Qiuyan Sun ,Chuan Yin ,Ki Hong Lee ,Yana Geng ,Presha Rajbhandari ,Celine Hernandez ,Marcella Steffani ,Jingran Qie ,Thomas Savage ,Dhruv M Goyal ,Kevin C Ray ,Taruna V Neelakantan ,Deqi Yin ,Johannes Melms ,Brandon M Lehrich ,Tyler M Yasaka ,Silvia Liu ,Michael Oertel ,Tian Lan ,Adrien Guillot ,Moritz Peiseler ,Aveline Filliol ,Hiroaki Kanzaki ,Naoto Fujiwara ,Samhita Ravi ,Benjamin Izar ,Mario Brosch ,Jochen Hampe ,Helen Remotti ,Josepmaria Argemi ,Zhaoli Sun ,Timothy J Kendall ,Yujin Hoshida ,Frank Tacke ,Jonathan A Fallowfield ,Storm K Blockley-Powell ,Rebecca A Haeusler ,Jonathan B Steinman ,Utpal B Pajvani ,Satdarshan P Monga ,Ramon Bataller ,Mojgan Masoodi ,Nicholas Arpaia ,Youngmin A Lee ,Brent R Stockwell ,Hellmut G Augustin ,Robert F Schwabe

Novel NPY2R agonist BI 1820237 provides synergistic anti-obesity efficacy when combined with the GCGR/GLP-1R dual agonist survodutide

新型NPY2R激动剂BI 1820237与GCGR/GLP-1R双重激动剂苏沃度肽联合使用时,可产生协同抗肥胖疗效。

Augustin, Robert; Oldenburger, Anouk; Baader-Pagler, Tamara; Zimmermann, Tina; Borghardt, Jens; Hecksher-Sørensen, Jacob; Baljuls, Angela; Reindl, Wolfgang; Krawczyk, Bartlomiej; Martel, Eric; Brennauer, Albert; Peters, Stefan; Grube, Achim; Rudkjaer, Lise Biehl; Haebel, Peter

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.

针对 cAMP 偏向信号传导优化的 GLP-1 类似物可改善肥胖小鼠的体重减轻

Douros Jonathan D, Novikoff Aaron, DuBois Barent, Rohlfs Rebecca, Mokrosinski Jacek, Hogendorf Wouter F J, Augustin Robert, Merkestein Myrte, Egaa Martini Lene Brandt, Linderoth Lars, Gerrard Elliot, Kodra Janos Tibor, Norlin Jenny, Roed Nikolaj Kulahin, Oldenburger Anouk, Mowery Stephanie A, Waldhoer Maria, Perez-Tilve Diego, Finan Brian, Reedtz-Runge Steffen, Müller Timo D, Knerr Patrick J

Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application

以能量消耗作为肥胖症治疗方法所面临的挑战:从临床前模型到临床应用

Löffler, Mona C; Betz, Matthias J; Blondin, Denis P; Augustin, Robert; Sharma, Anand K; Tseng, Yu-Hua; Scheele, Camilla; Zimdahl, Heike; Mark, Michael; Hennige, Anita M; Wolfrum, Christian; Langhans, Wolfgang; Hamilton, Bradford S; Neubauer, Heike

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

SGLT2在胰岛α细胞和β细胞中不表达,抑制SGLT2并不直接影响啮齿动物和人类的胰高血糖素和胰岛素分泌。

Chae, Heeyoung; Augustin, Robert; Gatineau, Eva; Mayoux, Eric; Bensellam, Mohammed; Antoine, Nancy; Khattab, Firas; Lai, Bao-Khanh; Brusa, Davide; Stierstorfer, Birgit; Klein, Holger; Singh, Bilal; Ruiz, Lucie; Pieper, Michael; Mark, Michael; Herrera, Pedro L; Gribble, Fiona M; Reimann, Frank; Wojtusciszyn, Anne; Broca, Christophe; Rita, Nano; Piemonti, Lorenzo; Gilon, Patrick

The apical sorting signal for human GLUT9b resides in the N-terminus

人类GLUT9b的顶端分选信号位于N端。

Bibee, Kristin P; Augustin, Robert; Gazit, Vered; Moley, Kelle H

Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction

睾丸中GLUT8的溶酶体定位——GLUT8的EXXXLL基序足以通过AP1和AP2介导的相互作用进行细胞内分选。

Diril, Muhammed Kasim; Schmidt, Stefan; Krauss, Michael; Gawlik, Verena; Joost, Hans-Georg; Schürmann, Annette; Haucke, Volker; Augustin, Robert