日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis

SALL4B 不是 IMiD 的靶点,但它对 SALL4 介导的肿瘤发生至关重要。

L Vu, Kim Anh; Kumari, Kalpana; Liu, Bee Hui; Gao, Chong; Li, Feng; Tang, Jing Ping; Maddalo, Danilo; Auld, Douglas S; Casalena, Dominick E; Tian, Xi; Liu, Miao; Bassal, Mahmoud A; Moein, Shiva; Iakovleva, Viktoriia; Tan, Justin L; Stein, Alicia J; Zhou, Qiling; Fischer, Patrick D; Sigua, Logan H; Qi, Jun; Arthanari, Haribabu; Tenen, Daniel G; Chai, Li

The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation

NCATS检测指导手册计划:推进临床前转化实践和严谨性

Markossian, Sarine; Brimacombe, Kyle R; Sittampalam, G Sitta; Grossman, Abigail; Coussens, Nathan P; Inglese, James; Auld, Douglas S; Chin, William; Austin, Christopher P; Hall, Matthew D

Nuisance compounds in cellular assays

细胞检测中的干扰化合物

Dahlin, Jayme L; Auld, Douglas S; Rothenaigner, Ina; Haney, Steve; Sexton, Jonathan Z; Nissink, J Willem M; Walsh, Jarrod; Lee, Jonathan A; Strelow, John M; Willard, Francis S; Ferrins, Lori; Baell, Jonathan B; Walters, Michael A; Hua, Bruce K; Hadian, Kamyar; Wagner, Bridget K

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

用于药物筛选的高通量三维肿瘤球体的构建

Griner, Lesley Mathews; Gampa, Kalyani; Do, Toan; Nguyen, Huyen; Farley, David; Hogan, Christopher J; Auld, Douglas S; Silver, Serena J

Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase

生物发光法在定量高通量筛选 (qHTS) 中检测激酶,应用于 Yes1 酪氨酸激酶、葡萄糖激酶和 PI5P4Kα 脂质激酶。

Davis, Mindy I; Auld, Douglas S; Inglese, James

Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation

变异组学筛选鉴定出钙激活氯离子通道 ANO1 的重入环,该重入环促进通道激活。

Bill, Anke; Popa, M Oana; van Diepen, Michiel T; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A; Auld, Douglas S; Gosling, Martin; Groot-Kormelink, Paul J; Gaither, L Alex

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

鉴定出ML251,一种强效的布氏锥虫和克氏锥虫磷酸果糖激酶抑制剂

Brimacombe, Kyle R; Walsh, Martin J; Liu, Li; Vásquez-Valdivieso, Montserrat G; Morgan, Hugh P; McNae, Iain; Fothergill-Gilmore, Linda A; Michels, Paul A M; Auld, Douglas S; Simeonov, Anton; Walkinshaw, Malcolm D; Shen, Min; Boxer, Matthew B

Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs

从已批准药物库中筛选治疗慢性淋巴细胞白血病的候选药物

Shen, Min; Zhang, Yaqin; Saba, Nakhle; Austin, Christopher P; Wiestner, Adrian; Auld, Douglas S

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

一类新型共价抑制剂可阻断核苷酸与丙酮酸激酶活性位点的结合

Morgan Hugh P, Walsh Martin J, Blackburn Elizabeth A, Wear Martin A, Boxer Matthew B, Shen Min, Veith Henrike, McNae Iain W, Nowicki Matthew W, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D

Identification of clinically used drugs that activate pregnane X receptors

鉴定临床上使用的能激活孕烷X受体的药物

Shukla, Sunita J; Sakamuru, Srilatha; Huang, Ruili; Moeller, Timothy A; Shinn, Paul; Vanleer, Danielle; Auld, Douglas S; Austin, Christopher P; Xia, Menghang