日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection

宿主导向的恶二唑化合物通过人类巨噬细胞和小鼠感染模型中的锌中毒增强抗结核治疗

Alexandra Maure, Emeline Lawarée, Francesco Fiorentino, Alexandre Pawlik, Saideep Gona, Alexandre Giraud-Gatineau, Matthew J G Eldridge, Anne Danckaert, David Hardy, Wafa Frigui, Camille Keck, Claude Gutierrez, Olivier Neyrolles, Nathalie Aulner, Antonello Mai, Mélanie Hamon, Luis B Barreiro, Prisci

Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge

鉴定细菌感染后肠上皮细胞中β-防御素-2表达所需的人类宿主因子

Wozniak, Weronika; Sechet, Emmanuel; Kwon, Yong-Jun; Aulner, Nathalie; Navarro, Lionel; Sperandio, Brice

An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus

基于马 iPSC 的表型筛选平台可识别针对西尼罗河病毒的亲病毒和抗病毒分子

Marielle Cochet, François Piumi, Kamila Gorna, Noémie Berry, Gaëlle Gonzalez, Anne Danckaert, Nathalie Aulner, Odile Blanchet, Stéphan Zientara, Francesc Xavier Donadeu, Hélène Munier-Lehmann, Jennifer Richardson, Alexandra Benchoua, Muriel Coulpier

Complete Genome Sequences of Cluster S Mycobacteriophages Beelzebub, Raela, and RedRaider77

S簇分枝杆菌噬菌体Beelzebub、Raela和RedRaider77的完整基因组序列

Sevcik, Kristina; Preston, Peace; Aulner, Michaela; Noordewier, Byron; Tolsma, Sara S

Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

利用强大的基于细胞的协议揭示人类成纤维细胞先天免疫反应的个体间变异

Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L Shorte, Brigitte David-Watine

LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images

LocalZProjector 和 DeProj:用于大型 3D 显微镜图像的局部 2D 投影和精确形态测量的工具箱

Sébastien Herbert #, Léo Valon #, Laure Mancini, Nicolas Dray, Paolo Caldarelli, Jérôme Gros, Elric Esposito, Spencer L Shorte, Laure Bally-Cuif, Nathalie Aulner, Romain Levayer, Jean-Yves Tinevez

Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response

以巨噬细胞组蛋白 H3 修饰为靶点作为利什曼原虫抑制 NF-κB/NLRP3 介导的炎症反应的策略

Hervé Lecoeur, Eric Prina, Thibault Rosazza, Kossiwa Kokou, Paya N'Diaye, Nathalie Aulner, Hugo Varet, Giovanni Bussotti, Yue Xing, Geneviève Milon, Robert Weil, Guangxun Meng, Gerald F Späth

Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening

通过比较表型筛选发现对内脏和皮肤利什曼原虫具有广谱活性的新型先导化合物。

Lamotte, S; Aulner, N; Späth, G F; Prina, E

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

从药物筛选到靶标反卷积:基于靶标的药物发现流程,利用利什曼原虫酪蛋白激酶 1 同工型 2 来识别具有抗利什曼原虫活性的化合物

Emilie Durieu, Eric Prina, Olivier Leclercq, Nassima Oumata, Nicolas Gaboriaud-Kolar, Konstantina Vougogiannopoulou, Nathalie Aulner, Audrey Defontaine, Joo Hwan No, Sandrine Ruchaud, Alexios-Leandros Skaltsounis, Hervé Galons, Gerald F Späth, Laurent Meijer, Najma Rachidi

Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

药理学评估确定杜氏利什曼原虫酪蛋白激酶1为药物靶点,并揭示其在寄生虫存活和细胞内感染中的重要功能。

Rachidi, Najma; Taly, Jean François; Durieu, Emilie; Leclercq, Olivier; Aulner, Nathalie; Prina, Eric; Pescher, Pascale; Notredame, Cedric; Meijer, Laurent; Späth, Gerald F