Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
拓扑异构酶抑制剂Topobexin靶向拓扑异构酶II ATPase结构域，选择性抑制β亚型，发挥蒽环类药物心脏保护作用
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60167-9
KubeÅ¡ Jan, Karabanovich Galina, Cong Anh T Q, Melnikova Iuliia, LenÄová Olga, Kollárová Petra, BavloviÄ PiskáÄková Hana, KeresteÅ¡ Veronika, Applová Lenka, Arrouye Lise C M, Alvey Julia R, Paluncic Jasmina, Witter Taylor L, Jirkovská Anna, KuneÅ¡ JiÅÃ, Å tÄrbová-KovaÅÃková Petra, Austin Caroline A, Å tÄrba Martin, Å imůnek Tomáš, Roh Jaroslav, Schellenberg Matthew J
