日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

识别抗淀粉样蛋白伴侣样 BRICHOS 结构域阻断的 Aβ42 原纤维上的潜在聚集热点

Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

分子伴侣结构域 Bri2 BRICHOS 对 α-突触核蛋白寡聚体的生成和毒性有特异性的抑制作用

Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E Otzen, Jan Johansson, Axel Abelein

Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain

BRICHOS 结构域不同底物结合位点和分子伴侣功能的分子基础

Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson

Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer's disease pathology in mouse models

使用针对 β-淀粉样蛋白毒性的分子伴侣进行静脉注射治疗可改善小鼠模型中的阿尔茨海默病病理

Shaffi Manchanda, Lorena Galan-Acosta, Axel Abelein, Simone Tambaro, Gefei Chen, Per Nilsson, Jan Johansson

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

BRICHOS 结构域中的短疏水环基序决定了分子伴侣对抗无定形蛋白质聚集的活性,但不对抗淀粉样蛋白的形成

Gefei Chen #, Axel Leppert #, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson

Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform

蛛丝蛋白 N 端结构域形成基于淀粉样蛋白原纤维的水凝胶并提供蛋白质固定平台

Tina Arndt, Kristaps Jaudzems, Olga Shilkova, Juanita Francis, Mathias Johansson, Peter R Laity, Cagla Sahin, Urmimala Chatterjee, Nina Kronqvist, Edgar Barajas-Ledesma, Rakesh Kumar, Gefei Chen, Roger Strömberg, Axel Abelein, Maud Langton, Michael Landreh, Andreas Barth, Chris Holland, Jan Johansso

Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration

外周给药后,同位素标记的β-淀粉样蛋白不会以类似朊病毒的方式传递到大脑。

Mirjam Brackhan ,Giulio Calza ,Kristiina Lundgren ,Pablo Bascuñana ,Thomas Brüning ,Rabah Soliymani ,Rakesh Kumar ,Axel Abelein ,Marc Baumann ,Maciej Lalowski ,Jens Pahnke

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis

脑脊液装饰蛋白增加可预测阿尔茨海默病 Aβ 淀粉样变性引起的脑病理变化

Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C Saido, Vesna Jelic, Stina Syvän

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

BRICHOS 结构域预防神经毒性和纤维形成的能力依赖于高度保守的 Asp 残基

Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska, Axel Abelein, Axel Leppert, Nina Kronqvist, Anna Rising, Hans Hebert, Philip J B Koeck, André Fisahn, Jan Johansson

Autophagy Impairment in App Knock-in Alzheimer's Model Mice

App 基因敲入阿尔茨海默病模型小鼠的自噬受损

Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein, Bengt Winblad, Nenad Bogdanovic, Per Nilsson