日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain

BRICHOS 结构域不同底物结合位点和分子伴侣功能的分子基础

Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson

The heat shock protein LarA activates the Lon protease in response to proteotoxic stress

热休克蛋白 LarA 可激活 Lon 蛋白酶来应对蛋白毒性应激

Deike J Omnus #, Matthias J Fink #, Aswathy Kallazhi, Maria Xandri Zaragoza, Axel Leppert, Michael Landreh, Kristina Jonas

Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation

BRICHOS 结构域中的短疏水环基序决定了分子伴侣对抗无定形蛋白质聚集的活性,但不对抗淀粉样蛋白的形成

Gefei Chen #, Axel Leppert #, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson

ATP-independent molecular chaperone activity generated under reducing conditions

还原条件下产生的不依赖 ATP 的分子伴侣活性

Axel Leppert, Gefei Chen, Danai Lianoudaki, Chloe Williams, Xueying Zhong, Jonathan D Gilthorpe, Michael Landreh, Jan Johansson

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

BRICHOS 结构域预防神经毒性和纤维形成的能力依赖于高度保守的 Asp 残基

Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska, Axel Abelein, Axel Leppert, Nina Kronqvist, Anna Rising, Hans Hebert, Philip J B Koeck, André Fisahn, Jan Johansson

Maresin 1 attenuates pro-inflammatory activation induced by β-amyloid and stimulates its uptake

Maresin 1 可减弱 β-淀粉样蛋白诱导的促炎激活并刺激其吸收

Ying Wang, Axel Leppert, Shuai Tan, Bram van der Gaag, Nailin Li, Marianne Schultzberg, Erik Hjorth

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

重组 Bri3 BRICHOS 结构域是一种分子伴侣,具有抗淀粉样蛋白形成和非纤维蛋白聚集的作用

Helen Poska, Axel Leppert, Helene Tigro, Xueying Zhong, Margit Kaldmäe, Harriet E Nilsson, Hans Hebert, Gefei Chen, Jan Johansson