日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and optimization of first-in-class RNA helicase inhibitors of DDX1, LGP2, and MDA5

鉴定和优化首创的DDX1、LGP2和MDA5 RNA解旋酶抑制剂

Wang, Xiaowen; Wang, Feijun; Kong, Deyu; Uredi, Dilipkumar; Li, Fengling; Li, Feng; Rayadurgam, Jayachandra; Li, Hanxuan; Wolf, Esther; Chan, U Hang; Chau, Irene; Zeng, Hong; Perez, Julia Garcia; Wilson, Derek J; Bashore, Frances M; Wang, Xiaodong; Halabelian, Levon; Frankowski, Kevin J; Kireev, Dmitri; Axtman, Alison D

A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells

多激酶抑制剂筛选鉴定出能够维持干细胞样嵌合抗原受体T细胞的抑制剂

Feifei Song ,Ourania Tsahouridis ,Simone Stucchi ,Tara Walhart ,Sophie Mendell ,P Brian Hardy ,Matthew Axtman ,Shiva K R Guduru ,Thomas S K Gilbert ,Lee M Graves ,Laura E Herring ,Barbara Savoldo ,Xingcong Ma ,Mark Woodcock ,Justin J Milner ,Anastasia Ivanova ,Kenneth H Pearce ,Yang Xu ,Gianpietro Dotti

Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve

PIKfyve 第二代体内化学探针的开发

Sophia M Min, Frances M Bashore, Jeffery L Smith, Tammy M Havener, Stefanie Howell, Haoxi Li, Rafael M Couñago, Konstantin I Popov, Alison D Axtman

Targeting Na(v)1.7 and Na(v)1.8 with a PIKfyve inhibitor to reverse inflammatory and neuropathic pain.

使用 PIKfyve 抑制剂靶向 Na(v)1.7 和 Na(v)1.8 来逆转炎症性和神经性疼痛

Rodríguez-Palma Erick J, Loya-Lopez Santiago, Min Sophia M, Calderon-Rivera Aida, Gomez Kimberly, Khanna Rajesh, Axtman Alison D

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication

不仅仅是酰胺生物电子等排体:发现含 1,2,4-三唑的吡唑并[1,5- a]嘧啶宿主 CSNK2 抑制剂用于对抗 β-冠状病毒复制

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2

通过战略性氟化获得强效、选择性、代谢稳定且口服生物可利用的 CSNK2 抑制剂

Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael M Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David H Drewry, Timothy M Willson

Illumination of understudied ciliary kinases

对研究不足的纤毛激酶的揭示

Flax, Raymond G; Rosston, Peter; Rocha, Cecilia; Anderson, Brian; Capener, Jacob L; Durcan, Thomas M; Drewry, David H; Prinos, Panagiotis; Axtman, Alison D

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants

针对获得功能变体的 SYK NanoBRET 细胞靶标参与检测的开发

Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Sabrina C D Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B Robers, Alison D Axtman, Frances M Bashore

Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants

开发用于功能获得性变异体的SYK NanoBRET细胞靶标结合分析方法

Capener, Jacob L; Vasta, James D; Katis, Vittorio L; Michaud, Ani; Beck, Michael T; Daglish, Sabrina C D; Cohen-Kedar, Sarit; Barda, Efrat Shaham; Howell, Stefanie; Dotan, Iris; Robers, Matthew B; Axtman, Alison D; Bashore, Frances M

Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen

利用聚焦DNA编码文库筛选发现53BP1小分子拮抗剂

Devan J Shell ,Caroline A Foley ,Qinhong Wang ,Chelsea M Smith ,Shiva K R Guduru ,Hong Zeng ,Aiping Dong ,Jacqueline L Norris-Drouin ,Matthew Axtman ,P Brian Hardy ,Gaorav Gupta ,Levon Halabelian ,Stephen V Frye ,Lindsey I James ,Kenneth H Pearce