日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fast and slow strains of misfolded mutant superoxide dismutase 1 in familial amyotrophic lateral sclerosis

家族性肌萎缩侧索硬化症中错误折叠突变超氧化物歧化酶 1 的快慢两种菌株

Xu, Guilian; Dillon, Kristy; Lopez, Amanda; Brkic, Selma; Fromholt, Susan; Ostrow, Lyle W; Glass, Jonathan D; Chakrabarty, Paramita; Ayers, Jacob I; Borchelt, David R

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

多种因素影响SOD1转基因小鼠ALS朊病毒样传播的潜伏期

Ayers, Jacob I; Xu, Guilian; Lu, Qing; Dillon, Kristy; Fromholt, Susan; Borchelt, David R

Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

肌萎缩侧索硬化症的表型多样性及多构象蛋白错误折叠的作用

Ayers, Jacob I; Borchelt, David R

Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

表达人超氧化物歧化酶 1 的小鼠对朊病毒样播散的易感性存在差异:一级氨基酸序列影响的研究

Ayers, Jacob I; Xu, Guilian; Dillon, Kristy; Lu, Qing; Chen, Zhijuan; Beckman, John; Moreno-Romero, Alma K; Zamora, Diana L; Galaleldeen, Ahmad; Borchelt, David R

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

与肌萎缩侧索硬化症相关的SOD1突变体增强成年运动神经元的神经突生长和分支

Osking, Zachary; Ayers, Jacob I; Hildebrandt, Ryan; Skruber, Kristen; Brown, Hilda; Ryu, Daniel; Eukovich, Amanda R; Golde, Todd E; Borchelt, David R; Read, Tracy-Ann; Vitriol, Eric A

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

超氧化物歧化酶 1 中暴露于溶剂的赖氨酸残基的电荷丢失突变不会在培养细胞模型中诱导包涵体形成。

Crosby, Keith; Crown, Anthony M; Roberts, Brittany L; Brown, Hilda; Ayers, Jacob I; Borchelt, David R

Prion-like Spreading in Tauopathies

tau蛋白病中的朊病毒样传播

Ayers, Jacob I; Giasson, Benoit I; Borchelt, David R

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

野生型和突变型α-突触核蛋白聚集的局部诱导揭示了其沿神经解剖通路传播的现象

Ayers, Jacob I; Riffe, Cara J; Sorrentino, Zachary A; Diamond, Jeffrey; Fagerli, Eric; Brooks, Mieu; Galaleldeen, Ahmad; Hart, P John; Giasson, Benoit I

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

超氧化物歧化酶-1中的赖氨酸酰化通过静电作用抑制具有朊病毒样种子结构的纤维形成

Rasouli, Sanaz; Abdolvahabi, Alireza; Croom, Corbin M; Plewman, Devon L; Shi, Yunhua; Ayers, Jacob I; Shaw, Bryan F

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

转基因小鼠外周注射α-突触核蛋白原纤维后出现明显的中枢神经系统病理

Ayers, Jacob I; Brooks, Mieu M; Rutherford, Nicola J; Howard, Jasie K; Sorrentino, Zachary A; Riffe, Cara J; Giasson, Benoit I