日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineered multifunctional transforming growth factor-β type II receptor ectodomain fusions for oncology applications

用于肿瘤治疗的工程化多功能转化生长因子-β II型受体胞外域融合蛋白

Lenferink, Anne E G; Zwaagstra, John C; Baardsnes, Jason; Delafosse, Laurence; Parat, Marie; Iqbal, Umar; Lessard, Etienne; Haqqani, Arsalan S; Jezierski, Anna; Abu-Thuraia, Afnan; Tabariès, Sébastien; Siegel, Peter M; Sulea, Traian

Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model.

改变 SARS-CoV-2 刺突蛋白亚单位疫苗的糖基化特征,可以改变小鼠模型中体液免疫反应的集中程度

Renner Tyler M, Stuible Matthew, Rossotti Martin A, Rohani Nazanin, Cepero-Donates Yuneivy, Sauvageau Janelle, Deschatelets Lise, Dudani Renu, Harrison Blair A, Baardsnes Jason, Koyuturk Izel, St Michael Frank, Hill Jennifer J, Hemraz Usha D, Lenferink Anne E G, Tanha Jamshid, Fernandes Barbara, Roldao Antonio, McCluskie Michael J, Akache Bassel, Durocher Yves

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity

一种抗 HER2 双互补位抗体,可诱导独特的 HER2 聚集和补体依赖性细胞毒性

Nina E Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O'Toole, Elizabeth Whalen, Peter W Y Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E Atkinson, Jason Baardsnes, Liam J Worrall, Duncan Browman, E

TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival

TNX-1500 是一种可结晶片段修饰的抗 CD154 抗体,可延长非人类灵长类动物肾移植存活期

Grace Lassiter, Ryo Otsuka, Takayuki Hirose, Ivy Rosales, Ahmad Karadagi, Toshihide Tomosugi, Abbas Dehnadi, Hang Lee, Robert B Colvin, Jason Baardsnes, Anna Moraitis, Emma E Smith, Zahida Ali, Phil Berhe, Andrew Mulder, Bernd Meibohm, Bruce Daugherty, Siobhan Fogarty, Richard N Pierson, Seth Lederm

Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

调节免疫反应:硫酸化古细菌糖脂古菌体作为有效的疫苗佐剂,可诱导针对 SARS-CoV-2 Omicron 变体的体液和细胞介导免疫

Tyler M Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J Hill, Usha D Hemraz, Sophie Régnier, Anne E G Lenferink, Yves Durocher, Michael J McCluskie

Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold

探索生物制剂发现中的刚性骨架蛋白质对接:使用 DARPin 支架进行的测试

Francis Gaudreault, Jason Baardsnes, Yuliya Martynova, Aurore Dachon, Hervé Hogues, Christopher R Corbeil, Enrico O Purisima, Mélanie Arbour, Traian Sulea

Structure-based dual affinity optimization of a SARS-CoV-1/2 cross-reactive single-domain antibody

基于结构的 SARS-CoV-1/2 交叉反应单域抗体双亲和力优化

Traian Sulea, Jason Baardsnes, Matthew Stuible, Nazanin Rohani, Anh Tran, Marie Parat, Yuneivy Cepero Donates, Mélanie Duchesne, Pierre Plante, Guneet Kour, Yves Durocher

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

氢-氘交换质谱揭示了针对 hCAIX 催化域的 mAb 的三种独特结合反应

Joey G Sheff, John F Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L'Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C Chafe, Paul C McDonald, Shoukat Dedhar,

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

分离和鉴定抗人碳酸酐酶IX的单克隆抗体

Anne E G Lenferink,Paul C McDonald,Christiane Cantin,Suzanne Grothé,Mylene Gosselin,Jason Baardsnes,Myriam Banville,Paul Lachance,Alma Robert,Yuneivy Cepero-Donates,Stevo Radinovic,Patrick Salois,Marie Parat,Hafida Oamari,Annie Dulude,Mehul Patel,Martin Lafrance,Andrea Acel,Nathalie Bousquet-Gagnon,Denis L'Abbé,Alex Pelletier,Félix Malenfant,Maria Jaramillo,Maureen O'Connor-Mccourt,Cunle Wu,Yves Durocher,Mélanie Duchesne,Christine Gadoury,Anne Marcil,Yves Fortin,Beatrice Paul-Roc,Maurizio Acchione,Shawn C Chafe,Oksana Nemirovsky,Joseph Lau,Francois Bénard,Shoukat Dedhar

Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences

通过虚拟筛选人类生殖系衍生序列小型文库重新设计抗体 H3 环

Christopher R Corbeil, Mahder Seifu Manenda, Traian Sulea, Jason Baardsnes, Marie-Ève Picard, Hervé Hogues, Francis Gaudreault, Christophe Deprez, Rong Shi, Enrico O Purisima