日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂,在胰腺导管腺癌中表现出强大的抗肿瘤活性。

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A

Pan-cancer Myc modulator that targets Myc-α-tubulin interaction to drive selective mitotic catastrophe

一种靶向Myc-α-微管蛋白相互作用以驱动选择性有丝分裂灾难的泛癌Myc调节剂

Teitel, Jessica; Farah, Margaret; Dziubinski, Michele L; Lee, Pil; White, Andrew; Sobeck, Alexander; Colina, Jose; Takyi-Williams, John; Wen, Bo; Nurmemmedov, Elmar; Babic, Ivan; Monteiro da Rocha, Andre; Bedi, Karan; Robida, Aaron; McIntyre, Grace; Hotta, Takashi; Lin, Yinzhi; Sekhar, Sreeja C; Ohi, Ryoma; DiFeo, Analisa

A phase 1 dose escalation of pritumumab in patients with refractory or recurrent gliomas or brain metastases

一项针对难治性或复发性胶质瘤或脑转移瘤患者的普利妥单抗1期剂量递增试验

Carrillo, Jose; Gill, Jaya Mini; Redfern, Charles; Babic, Ivan; Nomura, Natsuko; Shah, Dhaval K; Carrick, Sean; Kesari, Santosh

De-repression of PDGFRβ transcription promotes acquired resistance to EGFR tyrosine kinase inhibitors in glioblastoma patients.

PDGFRβ 转录的去抑制促进胶质母细胞瘤患者对 EGFR 酪氨酸激酶抑制剂产生获得性耐药性

Akhavan David, Pourzia Alexandra L, Nourian Alex A, Williams Kevin J, Nathanson David, Babic Ivan, Villa Genaro R, Tanaka Kazuhiro, Nael Ali, Yang Huijun, Dang Julie, Vinters Harry V, Yong William H, Flagg Mitchell, Tamanoi Fuyuhiko, Sasayama Takashi, James C David, Kornblum Harley I, Cloughesy Tim F, Cavenee Webster K, Bensinger Steven J, Mischel Paul S

EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.

EGFR 突变诱导的 Max 选择性剪接促进脑癌中糖酵解肿瘤的生长

Babic Ivan, Anderson Erik S, Tanaka Kazuhiro, Guo Deliang, Masui Kenta, Li Bing, Zhu Shaojun, Gu Yuchao, Villa Genaro R, Akhavan David, Nathanson David, Gini Beatrice, Mareninov Sergey, Li Rui, Camacho Carolina Espindola, Kurdistani Siavash K, Eskin Ascia, Nelson Stanley F, Yong William H, Cavenee Webster K, Cloughesy Timothy F, Christofk Heather R, Black Douglas L, Mischel Paul S

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

mTOR 复合物 2 通过 FoxO 乙酰化和 c-Myc 上调控制胶质母细胞瘤中的糖酵解代谢

Masui Kenta, Tanaka Kazuhiro, Akhavan David, Babic Ivan, Gini Beatrice, Matsutani Tomoo, Iwanami Akio, Liu Feng, Villa Genaro R, Gu Yuchao, Campos Carl, Zhu Shaojun, Yang Huijun, Yong William H, Cloughesy Timothy F, Mellinghoff Ingo K, Cavenee Webster K, Shaw Reuben J, Mischel Paul S

Multiple functions of a glioblastoma fusion oncogene

胶质母细胞瘤融合癌基因的多种功能

Babic, Ivan; Mischel, Paul S

The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas.

mTOR 激酶抑制剂 CC214-1 和 CC214-2 优先阻断 EGFRvIII 激活的胶质母细胞瘤的生长

Gini Beatrice, Zanca Ciro, Guo Deliang, Matsutani Tomoo, Masui Kenta, Ikegami Shiro, Yang Huijun, Nathanson David, Villa Genaro R, Shackelford David, Zhu Shaojun, Tanaka Kazuhiro, Babic Ivan, Akhavan David, Lin Kelly, Assuncao Alvaro, Gu Yuchao, Bonetti Bruno, Mortensen Deborah S, Xu Shuichan, Raymon Heather K, Cavenee Webster K, Furnari Frank B, James C David, Kroemer Guido, Heath James R, Hege Kristen, Chopra Rajesh, Cloughesy Timothy F, Mischel Paul S

Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance

致癌性 EGFR 信号通路激活 mTORC2-NF-κB 通路,从而促进化疗耐药性。

Tanaka, Kazuhiro; Babic, Ivan; Nathanson, David; Akhavan, David; Guo, Deliang; Gini, Beatrice; Dang, Julie; Zhu, Shaojun; Yang, Huijun; De Jesus, Jason; Amzajerdi, Ali Nael; Zhang, Yinan; Dibble, Christian C; Dan, Hancai; Rinkenbaugh, Amanda; Yong, William H; Vinters, Harry V; Gera, Joseph F; Cavenee, Webster K; Cloughesy, Timothy F; Manning, Brendan D; Baldwin, Albert S; Mischel, Paul S