日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates

口服奥贝地西韦可为非人灵长类动物提供暴露后针对马尔堡病毒的保护作用

Cross, Robert W; Woolsey, Courtney; Prasad, Abhishek N; Borisevich, Viktoriya; Agans, Krystle N; Deer, Daniel J; Harrison, Mack B; Dobias, Natalie S; Fenton, Karla A; Cihlar, Tomas; Nguyen, Anh-Quan; Babusis, Darius; Bannister, Roy; Vermillion, Meghan S; Chu, Victor C; Geisbert, Thomas W

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

口服核苷类似物奥贝地西韦对非洲绿猴的呼吸道合胞病毒感染有效。

Jared Pitts #,J Lizbeth Reyes Zamora #,Savrina Manhas,Thomas Aeschbacher,Josolyn Chan,Vincent Cutillas,Varsha Nair,Nicholas C Riola,Arya Vijjapurapu,Meghan S Vermillion,Stacey Eng,Christopher Richards,Dong Han,Jason K Perry,Subhra Chaudhuri,Szu-Wen Liu,Clarissa Martinez,Nadine Peinovich,Kai-Hui Sun,Arthur Cai,Ross Martin,Jasmine Moshiri,Charlotte Hedskog,Darius Babusis,Dustin S Siegel,Rao Kalla,Vasanthi Avadhanula,Pedro A Piedra,Kim Stobbelaar,Peter L Delputte,Caleb Marceau,Roberto Mateo,Evguenia Maiorova,Hongmei Mo,Raju Subramanian,Richard L Mackman,Tomas Cihlar,Simon P Fletcher,John P Bilello

The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection.

口服药物奥贝尔地西韦可保护非人灵长类动物免受致命的埃博拉病毒感染

Woolsey Courtney, Cross Robert W, Chu Victor C, Prasad Abhishek N, Agans Krystle N, Borisevich Viktoriya, Deer Daniel J, Harrison Mack B, Martinez Jasmine K, Dobias Natalie S, Fenton Karla A, Cihlar Tomas, Nguyen Anh-Quan, Babusis Darius, Bannister Roy, Vermillion Meghan S, Geisbert Thomas W

A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

HPIV-3 感染的稳健小鼠模型以及 GS-441524 对病毒诱发的肺部病理的疗效

Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts

A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques

一项随机、双盲、载体对照剂量范围研究,旨在评估和表征瑞德西韦对恒河猴埃博拉病毒的疗效

Zumbrun, Elizabeth E; Garvey, Carly B; Wells, Jay B; Lynn, Ginger C; Van Tongeren, Sean A; Steffens, Jesse T; Wetzel, Kelly S; Wetzel, Darrell L; Esham, Heather L; Garza, Nicole L; Lee, Eric D; Scruggs, Jennifer L; Rossi, Franco D; Brown, Elizabeth S; Weidner, Jessica M; Gomba, Laura M; O'Brien, Kristan A; Jay, Alexandra N; Zeng, Xiankun; Akers, Kristen S; Kallgren, Paul A; Englund, Ethan; Meinig, J Matthew; Kugelman, Jeffrey R; Moore, Joshua L; Bloomfield, Holly A; Norris, Sarah L; Bryan, Tameka; Scheuerell, Christie H; Walters, Jesse; Mollova, Nevena; Blair, Christiana; Babusis, Darius; Cihlar, Tomas; Porter, Danielle P; Singh, Bali; Hedskog, Charlotte; Bavari, Sina; Warren, Travis K; Bannister, Roy

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

发现 GS-5245(奥贝地西韦),这是核苷 GS-441524 的口服前药,对感染 SARS-CoV-2 的非洲绿猴具有抗病毒功效

Richard L Mackman, Rao V Kalla, Darius Babusis, Jared Pitts, Kimberly T Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B Michael O'Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Kassibla Elodie Dempah, Elaine Bunya

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing

食蟹猴马尔堡病毒病模型的特征分析及治疗试验时机的评估

Zumbrun, Elizabeth E; Garvey, Carly B; Wells, Jay B; Lynn, Ginger C; Van Tongeren, Sean; Steffens, Jesse T; Wetzel, Kelly S; Gomba, Laura M; O'Brien, Kristan A; Rossi, Franco D; Zeng, Xiankun; Lee, Eric D; Raymond, Jo Lynne W; Hoffman, Diana A; Jay, Alexandra N; Brown, Elizabeth S; Kallgren, Paul A; Norris, Sarah L; Cantey-Kiser, Jean; Kudiya, Humza; Arthur, Chris; Blair, Christiana; Babusis, Darius; Chu, Victor C; Singh, Bali; Bannister, Roy; Porter, Danielle P; Cihlar, Tomas; Dye, John M

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

口服核苷前药GS-5245(奥贝地西韦)对SARS-CoV-2和具有大流行潜力的冠状病毒的疗效

Martinez, David R; Moreira, Fernando R; Zweigart, Mark R; Gully, Kendra L; De la Cruz, Gabriela; Brown, Ariane J; Adams, Lily E; Catanzaro, Nicholas; Yount, Boyd; Baric, Thomas J; Mallory, Michael L; Conrad, Helen; May, Samantha R; Dong, Stephanie; Scobey, D Trevor; Montgomery, Stephanie A; Perry, Jason; Babusis, Darius; Barrett, Kimberly T; Nguyen, Anh-Hoa; Nguyen, Anh-Quan; Kalla, Rao; Bannister, Roy; Bilello, John P; Feng, Joy Y; Cihlar, Tomas; Baric, Ralph S; Mackman, Richard L; Schäfer, Alexandra; Sheahan, Timothy P

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

使用瑞德西韦母体核苷的口服前药进行治疗可预防小鼠感染 SARS-CoV-2

Alexandra Schäfer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T B

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

吸入瑞德西韦可减轻非人类灵长类动物 SARS-CoV-2 感染模型中的病毒负担

Meghan S Vermillion, Eisuke Murakami, Bin Ma, Jared Pitts, Adrian Tomkinson, Davin Rautiola, Darius Babusis, Hammad Irshad, Dustin Seigel, Cynthia Kim, Xiaofeng Zhao, Congrong Niu, Jesse Yang, Andrew Gigliotti, Nani Kadrichu, John P Bilello, Scott Ellis, Roy Bannister, Raju Subramanian, Bill Smith,