日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Endocrine-Disrupting Activities of Flavones on Steroid Receptors: Structural Requirements and Synthesis of Novel Flavone with Improved Estrogenic Activity

黄酮类化合物对类固醇受体的内分泌干扰活性：结构要求及新型黄酮的合成及其雌激素活性的增强

期刊:Biomedicines
影响因子:3.9
doi:10.3390/biomedicines13030748
Nordeen, Steven K; Kumar, Vijay; Bona, Betty J; Batson, Joshua D; Backos, Donald S; Wempe, Michael F
信号转导
免疫/内分泌
发表日期：2025
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Statin therapy inhibits fatty acid synthase via dynamic protein modifications

他汀类药物治疗通过动态蛋白质修饰抑制脂肪酸合酶

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-022-30060-w
Alec G Trub, Gregory R Wagner, Kristin A Anderson, Scott B Crown, Guo-Fang Zhang, J Will Thompson, Olga R Ilkayeva, Robert D Stevens, Paul A Grimsrud, Rhushikesh A Kulkarni, Donald S Backos, Jordan L Meier, Matthew D Hirschey
信号转导
WB
HMDH
发表日期：2022
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Iloprost requires the Frizzled-9 receptor to prevent lung cancer

伊洛前列素需要 Frizzled-9 受体来预防肺癌

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2022.104442
Kayla Sompel, Lori D Dwyer-Nield, Alex J Smith, Alamelu Elango, Don S Backos, Bicheng Zhang, James Gross, Kristina Ternyak, Jennifer L Matsuda, Katrina Kopf, Robert L Keith, Meredith A Tennis
肿瘤
肺癌
发表日期：2022
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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice

脱乙酰酶 SIRT5 对戊二酰辅酶 A 脱氢酶进行脱乙酰化，促进小鼠赖氨酸氧化

期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2022.101723
Dhaval P Bhatt, C Allie Mills, Kristin A Anderson, Bárbara J Henriques, Tânia G Lucas, Sara Francisco, Juan Liu, Olga R Ilkayeva, Alexander E Adams, Shreyas R Kulkarni, Donald S Backos, Michael B Major, Paul A Grimsrud, Cláudio M Gomes, Matthew D Hirschey
表观遗传
WB
Mouse
IgG light chain
发表日期：2022
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Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice

小鼠持续性、进行性肺纤维化和上皮重塑

期刊:American Journal of Respiratory Cell and Molecular Biology
影响因子:5.9
doi:10.1165/rcmb.2020-0542MA
Elizabeth F Redente, Bart P Black, Donald S Backos, Ali N Bahadur, Stephen M Humphries, David A Lynch, Rubin M Tuder, Rachel L Zemans, David W H Riches
发表日期：2021
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Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data

取代的蝶啶酮、嘧啶、吡咯并嘧啶和嘌呤作为p90核糖体S6蛋白激酶-2 (RSK2) 抑制剂：药效团模型数据

期刊:Data in Brief
影响因子:1.4
doi:10.1016/j.dib.2021.107433
Warfield, Becka M; Casalvieri, Kimberly A; Matheson, Christopher J; Backos, Donald S; Reigan, Philip
信号转导
发表日期：2021
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Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

取代的氧吲哚-3-亚甲基作为AMP激活蛋白激酶（AMPK）抑制剂

期刊:European Journal of Medicinal Chemistry
影响因子:6
doi:10.1016/j.ejmech.2020.112316
Christopher J Matheson ,Kimberly A Casalvieri ,Donald S Backos ,Mohammed Minhajuddin ,Craig T Jordan ,Philip Reigan
AMPK
信号转导
发表日期：2020
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Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes

NLRP3的计算模型揭示了与冷吡啉相关的周期性综合征中ATP结合和多聚化的增强

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2020.584364
Samson, Jenny Mae; Ravindran Menon, Dinoop; Vaddi, Prasanna K; Kalani Williams, Nazanin; Domenico, Joanne; Zhai, Zili; Backos, Donald S; Fujita, Mayumi
NLRP3
LRP3
发表日期：2020
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Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX

新型瞬时受体电位黑素 2 拮抗剂 tatM2NX 的表征与优化

期刊:Molecular Pharmacology
影响因子:3.2
doi:10.1124/mol.119.117549
I Cruz-Torres, D S Backos, P S Herson
信号转导
WB
发表日期：2020
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10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties

10-N-杂环芳基异噁唑酰胺（AIMs）对乳腺癌和脑癌细胞系具有强大的抗肿瘤活性，并具有有用的荧光特性。

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2020.115781
Weaver, Matthew J; Stump, Sascha; Campbell, Michael J; Backos, Donald S; Li, Chun; Reigan, Philip; Adams, Earle; Beall, Howard D; Natale, Nicholas R
肿瘤
IF
肿瘤免疫
神经科学
乳腺癌
细胞生物学
发表日期：2020
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