日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity

设计具有改进的体外ADME特性和降低的hERG亲和力的高效Menin-KMT2A相互作用抑制剂

Chapsal, Bruno D; Kimbrough, Jennifer R; Bester, Stephanie M; Bergstrom, Alex; Backos, Donald S; Campos, Bismarck; McDonald, Matthew G; Abrahamsen, Rebecca; Allen, Andrew C; Doerner Barbour, Patrick M; Bettendorf, Tanna; Boys, Mark L; Brown, Karin; Chicarelli, Mark J; Cook, Adam W; Crooks, Amy L; Cruz, Cole L; Dahlke, Joshua R; Eide, Alida; Fell, Jay B; Fulton, Jennifer L; Gargus, Matthew; Gaudino, John J; Guarnieri, Anna L; Hansen, Erik P; Holt, Melissa C; Kahn, Dean R; Laird, Ellen R; Larsen, Paul D; Linwood, Rebecca; Martinson, Matthew C; McCown, Joseph; Mejia, Macedonio J; Moreno, David A; Mou, Tung-Chung; Newhouse, Brad; O'Leary, Jacob M; Rodriguez, Martha E; Singh, Anurag; Sinik, Lenka; Strand, Keith A; Touney, Eric E; Wollenberg, Lance A; Wong, Jim; Zhou, Yeyun; Fischer, John P; Allen, Shelley

Endocrine-Disrupting Activities of Flavones on Steroid Receptors: Structural Requirements and Synthesis of Novel Flavone with Improved Estrogenic Activity

黄酮类化合物对类固醇受体的内分泌干扰活性:结构要求及新型黄酮的合成及其雌激素活性的增强

Nordeen, Steven K; Kumar, Vijay; Bona, Betty J; Batson, Joshua D; Backos, Donald S; Wempe, Michael F

The Lateral Metalation of Isoxazolo[3,4-d]pyridazinones towards Hit-to-Lead Development of Selective Positive Modulators of Metabotropic Glutamate Receptors

异噁唑并[3,4-d]哒嗪酮的侧向金属化在代谢型谷氨酸受体选择性正向调节剂的先导化合物开发中的应用

Gates, Christina A; Backos, Donald S; Reigan, Philip; Natale, Nicholas R

Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data

取代的蝶啶酮、嘧啶、吡咯并嘧啶和嘌呤作为p90核糖体S6蛋白激酶-2 (RSK2) 抑制剂:药效团模型数据

Warfield, Becka M; Casalvieri, Kimberly A; Matheson, Christopher J; Backos, Donald S; Reigan, Philip

Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes

NLRP3的计算模型揭示了与冷吡啉相关的周期性综合征中ATP结合和多聚化的增强

Samson, Jenny Mae; Ravindran Menon, Dinoop; Vaddi, Prasanna K; Kalani Williams, Nazanin; Domenico, Joanne; Zhai, Zili; Backos, Donald S; Fujita, Mayumi

10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties

10-N-杂环芳基异噁唑酰胺(AIMs)对乳腺癌和脑癌细胞系具有强大的抗肿瘤活性,并具有有用的荧光特性。

Weaver, Matthew J; Stump, Sascha; Campbell, Michael J; Backos, Donald S; Li, Chun; Reigan, Philip; Adams, Earle; Beall, Howard D; Natale, Nicholas R

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

4-羟基-2-壬烯醛可减弱8-氧鸟嘌呤DNA糖基化酶1的活性

Pan Guodong, Deshpande Mandar, Pang Haiyan, Stemmer Paul M, Carruthers Nicholas J, Shearn Colin T, Backos Donald S, Palaniyandi Suresh S

Molecular docking of substituted pteridinones and pyrimidines to the ATP-binding site of the N-terminal domain of RSK2 and associated MM/GBSA and molecular field datasets

取代蝶啶酮和嘧啶与RSK2 N端结构域ATP结合位点的分子对接以及相关的MM/GBSA和分子场数据集

Casalvieri, Kimberly A; Matheson, Christopher J; Backos, Donald S; Reigan, Philip

Identification and characterization of novel mutations implicated in congenital fibrinogen disorders

鉴定和表征与先天性纤维蛋白原疾病相关的新突变

Smith, Natalie; Bornikova, Larissa; Noetzli, Leila; Guglielmone, Hugo; Minoldo, Salvador; Backos, Donald S; Jacobson, Linda; Thornburg, Courtney D; Escobar, Miguel; White-Adams, Tara C; Wolberg, Alisa S; Manco-Johnson, Marilyn; Di Paola, Jorge

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4

异噁唑并[3,4-d]哒嗪酮正向调节代谢型谷氨酸受体亚型2和4

Gates, Christina; Backos, Donald S; Reigan, Philip; Kang, Hye Jin; Koerner, Chris; Mirzaei, Joseph; Natale, N R