日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Design, synthesis, in silico studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity

设计、合成、计算机模拟研究并评估了一系列新型噻唑/1,2,3-三唑杂合物作为凋亡诱导剂和多激酶抑制剂的抗增殖活性，这些杂合物具有抗乳腺癌活性。

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra07556d
Mohamed, Fatma A M; Alakilli, Saleha Y M; Alhassan, Hassan H; Yousif, Sara Osman; Alatwi, Eid; Gomaa, Hesham A M; Alrub, Heba Abu; Alyami, Bandar A; Abdelhafez, Ahmed H; Bräse, Stefan; Youssif, Bahaa G M
肿瘤
凋亡
表观遗传
肿瘤免疫
信号转导
乳腺癌
发表日期：2026
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Design, synthesis and antiproliferative, apoptotic, and immunomodulatory properties of new heteroaryl pyridine-linked 1,2,4-oxadiazoles as prospective dual EGFR/BRAF(V600E) inhibitors

新型杂芳基吡啶连接的1,2,4-恶二唑类化合物的设计、合成及其抗增殖、凋亡和免疫调节特性研究，旨在探索其作为潜在双重EGFR/BRAF(V600E)抑制剂的潜力。

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d6ra00207b
Gomaa, Hesham A M; Shaker, Mohamed E; Alzarea, Sami I; Alatwi, Eid; Mohamed, Fatma A M; Abdullah Alzahrani, Abdullah Yahya; Alyami, Bandar A; Bräse, Stefan; Rabea, Safwat M; Youssif, Bahaa G M
凋亡
表观遗传
EGF
BRAF
EGFR
免疫/内分泌
发表日期：2026
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Design, synthesis, and antibacterial assessment of a new series of ciprofloxacin-based compounds as possible dual DNA gyrase/topoisomerase IV inhibitors

设计、合成及抗菌活性评价一系列新型环丙沙星类化合物作为潜在的双重DNA促旋酶/拓扑异构酶IV抑制剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-50106-z
Al-Wahaibi, Lamya H; Alzahrani, Hayat Ali; Bräse, Stefan; Youssif, Bahaa G M; Hisham, Mohamed
发表日期：2026
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Design, synthesis, and antiproliferative activity of new 5-ethylsulfonyl-indazole-3-carbohydrazides as dual EGFR/VEGFR-2 kinases inhibitors

新型5-乙基磺酰基-吲唑-3-甲酰肼类化合物作为双重EGFR/VEGFR-2激酶抑制剂的设计、合成及抗增殖活性研究

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2516075
Al-Wahaibi, Lamya H; Abou-Zied, Hesham A; Mahmoud, Mohamed A; Youssif, Bahaa G M; Bräse, Stefan; Rabea, Safwat M
信号转导
EGF
EGFR
VEGF
发表日期：2025
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Design, synthesis, antiproliferative activity, and molecular dynamics simulation of pyrazoline-based derivatives as dual EGFR and HER-2 inhibitors

吡唑啉类衍生物作为双重EGFR和HER-2抑制剂的设计、合成、抗增殖活性及分子动力学模拟

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra01169h
Hafez, Hani Mohamed; Said, Basmat Amal M; Sayed, Ahmed M; Alatwi, Eid; Youssif, Bahaa G M; Bräse, Stefan; El-Sherief, Hany A M
EGFR
EGF
发表日期：2025
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Design, synthesis, and antiproliferative activity of new 2-amino-pyrano[3,2-c]quinoline-3-carbonitriles as potential EGFR, BRAF(V600E), and HER-2 inhibitors

新型2-氨基吡喃并[3,2-c]喹啉-3-腈类化合物的设计、合成及其作为潜在EGFR、BRAF(V600E)和HER-2抑制剂的抗增殖活性

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra04276c
Al-Wahaibi, Lamya H; Mohassab, Aliaa M; Rabea, Safwat M; Youssif, Bahaa G M; Bräse, Stefan; El-Sheref, Essmat M
EGFR
EGF
BRAF
发表日期：2025
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Design, synthesis, and apoptotic antiproliferative activity of novel dihydropyrimidine-5-carbonitrile/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors endowed with antioxidant activity

新型二氢嘧啶-5-腈/1,2,4-噁二唑杂合物的设计、合成及其作为具有抗氧化活性的双重EGFR/VEGFR-2抑制剂的凋亡抗增殖活性

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra05685c
Al-Wahaibi, Lamya H; Mohamed, Amira M; Abou-Zied, Hesham A; Abdullah Alzahrani, Abdullah Yahya; Bräse, Stefan; Youssif, Bahaa G M
凋亡
表观遗传
EGF
EGFR
VEGF
发表日期：2025
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Design, synthesis, and characterization of novel 5-ethylsulfonyl-indazole-3-carboxamides as dual VEGFR-2 and EGFR inhibitors: apoptotic antiproliferative and immunomodulatory evaluations

新型5-乙基磺酰基-吲唑-3-甲酰胺类化合物作为VEGFR-2和EGFR双重抑制剂的设计、合成和表征：凋亡抑制、抗增殖和免疫调节评价

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra07017a
Al-Wahaibi, Lamya H; Othman, Shimaa A; Abou-Zied, Hesham A; Bräse, Stefan; Youssif, Bahaa G M; Rabea, Safwat M
凋亡
表观遗传
EGF
EGFR
VEGF
免疫/内分泌
发表日期：2025
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Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties

设计、合成并研究新型噻唑类衍生物作为多靶点抑制剂的生物学特性，这些衍生物具有抗增殖、抗氧化和抗菌活性。

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2025.1595997
Gomaa, Hesham A M; Atta, Asmaa M; Shaker, Mohamed E; Alzarea, Sami I; Alsahli, Tariq G; Alatwi, Eid; Musa, Arafa; Mohamed, Fatma A M; Alzahrani, Hayat Ali; Mohassab, Aliaa M; Abdelmoez, Alshaimaa; Bräse, Stefan; Youssif, Bahaa G M
发表日期：2025
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Correction: Design, synthesis, antiproliferative assessments, and computational studies of new quinolin-2(1H)-ones as dual EGFR/HER-2 inhibitors

更正：新型喹啉-2(1H)-酮类化合物作为双重EGFR/HER-2抑制剂的设计、合成、抗增殖评估和计算研究

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2025.1748491
Al-Wahaibi, Lamya H; Abou-Zied, Hesham A; Nieger, Martin; Bräse, Stefan; Youssif, Bahaa G M; Tawfeek, Hendawy N
EGF
EGFR
发表日期：2025
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