日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader

发现 SD-965 是一种高效、选择性强且有效的 STAT3 PROTAC 降解剂

Wu, Dimin; Zhou, Haibin; Bai, Longchuan; Acharyya, Ranjan Kumar; Metwally, Hoda; McEachern, Donna; Wang, Mi; Tošović, Jelena; Rej, Rohan Kalyan; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng

MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration

MD-4251:一种首创的口服MDM2降解剂,单次给药即可诱导肿瘤完全消退

Acharyya, Ranjan Kumar; Huang, Liyue; Aguilar, Angelo; Hu, Biao; Bai, Longchuan; Metwally, Hoda; McEachern, Donna; Jiang, Wei; Wang, Yu; Li, Qiuxia; Wen, Bo; Sun, Duxin; Wang, Shaomeng

IL-4-STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock

IL-4-STAT6轴加剧组胺诱导的血管内皮功能障碍和低血容量性休克

Krempski, James; Yamani, Amnah; Thota, Lakshmi Narasimha Rao; Marella, Sahiti; Ganesan, Varsha; Sharma, Ankit; Kaneshige, Atsunori; Bai, Longchuan; Zhou, Haibin; Foster, Paul S; Wang, Shaomeng; Obi, Andrea T; Hogan, Simon P

Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer

发现 ERD-1233 是一种强效且口服有效的雌激素受体 PROTAC 降解剂,可用于治疗 ER+ 人类乳腺癌

Acharyya, Ranjan Kumar; Rej, Rohan Kalyan; Hu, Biao; Chen, Zhixiang; Wu, Dimin; Lu, Jianfeng; Metwally, Hoda; McEachern, Donna; Wang, Yu; Jiang, Wei; Bai, Longchuan; Tošović, Jelena; Gersch, Christina L; Xu, Guozhang; Zhang, Weihong; Wu, WenXue; Priestley, E Scott; Sui, Zhihua; Sarkari, Farzad; Wen, Bo; Sun, Duxin; Rae, James M; Wang, Shaomeng

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

SD-436 的发现:一种强效、高选择性和高效的 STAT3 PROTAC 降解剂,能够实现完全且持久的肿瘤消退

Xu, Renqi; Zhou, Haibin; Bai, Longchuan; McEachern, Donna; Wu, Dimin; Acharyya, Ranjan Kumar; Wang, Mi; Tošović, Jelena; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Meagher, Jennifer L; Stuckey, Jeanne A; Liu, Cai; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng

Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).

发现 ERD-12310A 是一种效力极强且口服有效的雌激素受体 α (ERα) PROTAC 降解剂。

Rej Rohan Kalyan, Hu Biao, Chen Zhixiang, Acharyya Ranjan Kumar, Wu Dimin, Metwally Hoda, McEachern Donna, Wang Yu, Jiang Wei, Bai Longchuan, Nishimura Leticia S, Gersch Christina L, Wang Meilin, Wen Bo, Sun Duxin, Carlson Kathryn, Katzenellenbogen John A, Xu Guozhang, Zhang Weihong, Wu Wenxue, Priestley E Scott, Sui Zhihua, Rae James M, Wang Shaomeng

Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors

基于Apcin的CDC20抑制剂的设计、合成和生物学评价

Bhuniya, Rajib; Yuan, Xinrui; Bai, Longchuan; Howie, Kathryn L; Wang, Rui; Li, Wei; Park, Frank; Yang, Chao-Yie

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

基于结构的 CF53 发现是一种强效且口服生物利用度高的溴结构域和末端外 (BET) 溴结构域抑制剂

Zhao Yujun, Zhou Bing, Bai Longchuan, Liu Liu, Yang Chao-Yie, Meagher Jennifer L, Stuckey Jeanne A, McEachern Donna, Przybranowski Sally, Wang Mi, Ran Xu, Aguilar Angelo, Hu Yang, Kampf Jeff W, Li Xiaoqin, Zhao Ting, Li Siwei, Wen Bo, Sun Duxin, Wang Shaomeng

MCL-1 inhibition in cancer treatment

MCL-1抑制剂在癌症治疗中的应用

Xiang, Weiguo; Yang, Chao-Yie; Bai, Longchuan

Small-molecule SMAC mimetics as new cancer therapeutics

小分子SMAC模拟物作为新型癌症治疗药物

Bai, Longchuan; Smith, David C; Wang, Shaomeng