Bai Ruoli相关文献与解析，生知库 | 链接生命科学的每一步

VanNatta, Jennifer M; Carlson, Graham J; Niu, Haichan; Bai, Ruoli; Wanniarachchi, Hashini I; Schuetze, Regan; Trawick, Mary Lynn; Hamel, Ernest; Mason, Ralph P; Pinney, Kevin G

发表日期：2025

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Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents

OXi8006 的 2-苯基吲哚类似物作为秋水仙碱位点抑制剂抑制微管蛋白聚合和血管破坏剂的设计、合成和生物学评价

期刊:Bioorganic & Medicinal Chemistry

影响因子:3

doi:10.1016/j.bmc.2024.117981

Vairin, Rebecca; Tamminga, Caleb; Shi, Zhe; Borchardt, Christian; Jambulapati, Jayaram; Bai, Ruoli; Wanniarachchi, Hashini; Bueno, Lorena; Hamel, Ernest; Mason, Ralph P; Trawick, Mary Lynn; Pinney, Kevin G

发表日期：2025

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Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers

具有独特双机制微管蛋白结合有效载荷的药物连接子结构，通过可切割和不可切割连接子连接

期刊:Tetrahedron

影响因子:2.2

doi:10.1016/j.tet.2024.134350

Ford, Jacob W; VanNatta, Jennifer M; Mondal, Deboprosad; Lin, Chen-Ming; Deng, Yuling; Bai, Ruoli; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G

发表日期：2025

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Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

吡咯并[3',4':3,4]环庚并[1,2-d][1,2]噁唑类化合物被鉴定为治疗淋巴瘤的潜在新候选药物

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2023.115372

Barreca, Marilia; Spanò, Virginia; Rocca, Roberta; Bivacqua, Roberta; Gualtieri, Gianmarco; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Manfreda, Lorenzo; Bai, Ruoli; Montalbano, Alessandra; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Viola, Giampietro; Barraja, Paola

淋巴瘤

发表日期：2023

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Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues

基于结构的含氧杂环丁烷吲哚类似物的设计、合成及生物学评价

期刊:Bioorganic & Medicinal Chemistry

影响因子:3

doi:10.1016/j.bmc.2023.117400

Ren, Wen; Vairin, Rebecca; Ward, Jacob D; Francis, Ricardo; VanNatta, Jenny; Bai, Ruoli; Tankoano, Pouguiniseli E; Deng, Yuling; Hamel, Ernest; Trawick, Mary Lynn; Pinney, Kevin G

发表日期：2023

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2-Difluoromethoxy-Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition

2-二氟甲氧基取代的雌三烯磺酰胺：合成、抗增殖构效关系、抗微管蛋白活性和类固醇硫酸酯酶抑制

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202200408

Dohle, Wolfgang; Asiki, Hannah; Gruchot, Wojciech; Foster, Paul A; Sahota, Havreen K; Bai, Ruoli; Christensen, Kirsten E; Hamel, Ernest; Potter, Barry V L

发表日期：2022

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The interaction of spongistatin 1 with tubulin

海绵抑素1与微管蛋白的相互作用

期刊:Archives of Biochemistry and Biophysics

影响因子:3

doi:10.1016/j.abb.2022.109296

Bai, Ruoli; Smith, Amos B 3rd; Pettit, George R; Hamel, Ernest

发表日期：2022

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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents

新型吡唑并[4,3-d]嘧啶微管靶向剂（MTAs）：合成、构效关系、体外和体内抗肿瘤活性评价

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2021.127923

Islam, Farhana; Quadery, Tasdique M; Bai, Ruoli; Luckett-Chastain, Lerin R; Hamel, Ernest; Ihnat, Michael A; Gangjee, Aleem

Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

吡咯并[2',3':3,4]环庚并[1,2-d][1,2]噁唑，一类新型抗有丝分裂剂，对多种恶性细胞类型有效

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.0c01315

Spanò, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai, Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola

细胞生物学

发表日期：2020

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Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

二芳基二硫化物和硫代磺酸酯作为康布瑞他汀A-4类似物：合成、细胞毒性和抗微管蛋白活性

期刊:Bioorganic Chemistry

影响因子:4.7

doi:10.1016/j.bioorg.2020.104017

Khodyuk, Rejane Gonçalves Diniz; Bai, Ruoli; Hamel, Ernest; Lourenço, Estela Mariana Guimarães; Barbosa, Euzébio Guimarães; Beatriz, Adilson; Dos Santos, Edson Dos Anjos; de Lima, Dênis Pires

Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization

苯并环庚烯及其四环类似物作为秋水仙碱位点抑制剂抑制微管蛋白聚合

Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents

OXi8006 的 2-苯基吲哚类似物作为秋水仙碱位点抑制剂抑制微管蛋白聚合和血管破坏剂的设计、合成和生物学评价

Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers

具有独特双机制微管蛋白结合有效载荷的药物连接子结构，通过可切割和不可切割连接子连接

Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

吡咯并[3',4':3,4]环庚并[1,2-d][1,2]噁唑类化合物被鉴定为治疗淋巴瘤的潜在新候选药物

Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues

基于结构的含氧杂环丁烷吲哚类似物的设计、合成及生物学评价

2-Difluoromethoxy-Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition

2-二氟甲氧基取代的雌三烯磺酰胺：合成、抗增殖构效关系、抗微管蛋白活性和类固醇硫酸酯酶抑制

The interaction of spongistatin 1 with tubulin

海绵抑素1与微管蛋白的相互作用

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents

新型吡唑并[4,3-d]嘧啶微管靶向剂（MTAs）：合成、构效关系、体外和体内抗肿瘤活性评价

Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

吡咯并[2',3':3,4]环庚并[1,2-d][1,2]噁唑，一类新型抗有丝分裂剂，对多种恶性细胞类型有效

Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity

二芳基二硫化物和硫代磺酸酯作为康布瑞他汀A-4类似物：合成、细胞毒性和抗微管蛋白活性