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Simultaneous multigene integration in Aspergillus fumigatus using CRISPR/Cas9 and endogenous counter-selectable markers

利用 CRISPR/Cas9 和内源性反向选择标记在烟曲霉中同时进行多基因整合

Sastré-Velásquez, Luis Enrique; Mach, Natalia; Mertens, Birte; Kühbacher, Alexander; Merschak, Petra; Dallemulle, Alex; Lechner, Lukas; Baldin, Clara; Diallinas, George; Gsaller, Fabio

发表日期：2025

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Development and optimization of large-scale approaches to identify iron-related genes in Aspergillus fumigatus.

开发和优化大规模方法以识别烟曲霉中的铁相关基因

期刊:Frontiers in Microbiology

影响因子:4.5

doi:10.3389/fmicb.2025.1646661

Baldin Clara, Binder Ulrike, Scheler Jakob, Werner Ernst R, Gsaller Fabio, Bromley Michael J, Haas Hubertus

其它

发表日期：2025

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Simply cut out - Combining CRISPR/Cas9 RNPs and transiently selected telomere vectors for marker free-gene deletion in Trichoderma atroviride

简单切割——结合 CRISPR/Cas9 RNP 和瞬时选择的端粒载体，实现木霉属真菌中无标记基因的敲除

期刊:Frontiers in Genome Editing

影响因子:4.4

doi:10.3389/fgeed.2025.1623963

Gründlinger, Mario; Ellensohn, Chiara; Drechsel, Leo; Schreiner, Ulrike; Pierson, Siebe; Baldin, Clara; Zeilinger, Susanne

微生物学

发表日期：2025

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Author Correction: Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

作者更正：对烟曲霉激酶组的功能分析发现了一种可成药的DYRK激酶，该激酶调节隔膜堵塞。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-024-50129-y

van Rhijn, Norman; Zhao, Can; Al-Furaiji, Narjes; Storer, Isabelle S R; Valero, Clara; Gago, Sara; Chown, Harry; Baldin, Clara; Grant, Rachael-Fortune; Bin Shuraym, Hajer; Ivanova, Lia; Kniemeyer, Olaf; Krüger, Thomas; Bignell, Elaine; Goldman, Gustavo H; Amich, Jorge; Delneri, Daniela; Bowyer, Paul; Brakhage, Axel A; Haas, Hubertus; Bromley, Michael J

The histone deacetylase Hda1 affects oxidative and osmotic stress response as well as mycoparasitic activity and secondary metabolite biosynthesis in Trichoderma atroviride

组蛋白去乙酰化酶Hda1影响绿色木霉的氧化应激和渗透应激反应，以及真菌寄生活性和次级代谢产物生物合成。

期刊:Microbiology Spectrum

影响因子:3.8

doi:10.1128/spectrum.03097-23

Speckbacher, Verena; Flatschacher, Daniel; Martini-Lösch, Nora; Ulbrich, Laura; Baldin, Clara; Bauer, Ingo; Ruzsanyi, Veronika; Zeilinger, Susanne

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

对烟曲霉激酶组的功能分析表明，参与隔膜堵塞的DYRK激酶是一种新型抗真菌药物靶点。

期刊:

影响因子:

doi:10.21203/rs.3.rs-2960526/v1

van Rhijn, Norman; Zhao, Can; Al-Furaji, Narjes; Storer, Isabelle; Valero, Clara; Gago, Sara; Chown, Harry; Baldin, Clara; Fortune-Grant, Rachael; Shuraym, Hajer Bin; Ivanova, Lia; Kniemeyer, Olaf; Krüger, Thomas; Bignell, Elaine; Goldman, Gustavo; Amich, Jorge; Delneri, Daniela; Bowyer, Paul; Brakhage, Axel; Haas, Hubertus; Bromley, Michael

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment

真菌排出5-氟胞嘧啶衍生的氟嘧啶会减弱其抗真菌活性并产生细胞毒性环境。

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1011066

Sastré-Velásquez, Luis Enrique; Dallemulle, Alex; Kühbacher, Alexander; Baldin, Clara; Alcazar-Fuoli, Laura; Niedrig, Anna; Müller, Christoph; Gsaller, Fabio

Modular Inducible Multigene Expression System for Filamentous Fungi

用于丝状真菌的模块化诱导多基因表达系统

期刊:Microbiology Spectrum

影响因子:3.8

doi:10.1128/spectrum.03670-22

Baldin, Clara; Kühbacher, Alexander; Merschak, Petra; Wagener, Johannes; Gsaller, Fabio

微生物学

发表日期：2022

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Inducible Selectable Marker Genes to Improve Aspergillus fumigatus Genetic Manipulation

利用诱导型选择标记基因改进烟曲霉的基因操作

期刊:Journal of Fungi

影响因子:4

doi:10.3390/jof7070506

Baldin, Clara; Kühbacher, Alexander; Merschak, Petra; Sastré-Velásquez, Luis Enrique; Abt, Beate; Dietl, Anna-Maria; Haas, Hubertus; Gsaller, Fabio

发表日期：2021

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Exploring salicylic acid biosynthesis in Trichoderma spp. using an enhanced transformation approach

利用增强转化方法探索木霉属真菌中水杨酸的生物合成

Simultaneous multigene integration in Aspergillus fumigatus using CRISPR/Cas9 and endogenous counter-selectable markers

利用 CRISPR/Cas9 和内源性反向选择标记在烟曲霉中同时进行多基因整合

Development and optimization of large-scale approaches to identify iron-related genes in Aspergillus fumigatus.

开发和优化大规模方法以识别烟曲霉中的铁相关基因

Simply cut out - Combining CRISPR/Cas9 RNPs and transiently selected telomere vectors for marker free-gene deletion in Trichoderma atroviride

简单切割——结合 CRISPR/Cas9 RNP 和瞬时选择的端粒载体，实现木霉属真菌中无标记基因的敲除

Author Correction: Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

作者更正：对烟曲霉激酶组的功能分析发现了一种可成药的DYRK激酶，该激酶调节隔膜堵塞。

The histone deacetylase Hda1 affects oxidative and osmotic stress response as well as mycoparasitic activity and secondary metabolite biosynthesis in Trichoderma atroviride

组蛋白去乙酰化酶Hda1影响绿色木霉的氧化应激和渗透应激反应，以及真菌寄生活性和次级代谢产物生物合成。

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

对烟曲霉激酶组的功能分析表明，参与隔膜堵塞的DYRK激酶是一种新型抗真菌药物靶点。

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment

真菌排出5-氟胞嘧啶衍生的氟嘧啶会减弱其抗真菌活性并产生细胞毒性环境。

Modular Inducible Multigene Expression System for Filamentous Fungi

用于丝状真菌的模块化诱导多基因表达系统

Inducible Selectable Marker Genes to Improve Aspergillus fumigatus Genetic Manipulation

利用诱导型选择标记基因改进烟曲霉的基因操作