SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism
SARS-CoV-2 ORF3a 通过干扰 VPS39 调控的 NPC2 转运和 BMP 代谢来阻断溶酶体胆固醇外流。
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doi:10.1101/2024.11.13.623299
Goodson, Baley A; Vazquez, Valeria Montenegro; Doyle, Aliza; Kolaczkowski, Oralia M; Liu, Rui; Jia, Jingyue; Ishida, Morié; Wang, Hu; Han, Xianlin; Ye, Chunyan; Kell, Alison M; Bradfute, Steven B; Lemus, Monica Rosas; Pu, Jing
