日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FOXJ1 mediates taxane resistance through regulation of microtubule dynamics.

FOXJ1 通过调节微管动力学介导紫杉烷类药物耐药性。

Xie Fang, Gjyrezi Ada, Fein Daniel, Labaf Maryam, Poluben Larysa, Ersoy-Fazlioglu Betul, Dennehy Christopher M, Voznesensky Olga, Gad Aniket, Corey Eva, Varkaris Andreas, Einstein David J, Bhatt Rupal S, Giannakakou Paraskevi, Balk Steven P

Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer

在同源重组功能正常的的前列腺癌中,AR靶向疗法与PARP抑制剂之间缺乏协同作用

Traphagen, Nicole A; Wheeler, Esmé; Li, Rong; Akhshi, Tara; Ravindranathan, Ramya; Alfieri, Christian; Lu, Feng; Ahmed, Buraq; Tewari, Alok K; Balk, Steven P; Nelson, Peter S; Corey, Eva; Long, Henry; D'Andrea, Alan D; Qiu, Xintao; Brown, Myles

Preclinical Activity of the DLL3-Targeted T-cell Engager MK-6070 in Neuroendocrine Prostate Cancer

DLL3靶向T细胞衔接剂MK-6070在神经内分泌前列腺癌中的临床前活性

Ku, Sheng-Yu; Manzar, Nishat; Garcia, Maria Mica; Kim, Min Jin; Einstein, David J; Balk, Steven P; Yamada, Yasutaka; Beltran, Himisha

Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.

阐明针对致命性前列腺癌的 MCL1 分子分层单药和联合治疗策略。

Jiménez-Vacas Juan M, Westaby Daniel, Figueiredo Ines, De Haven Brandon Alexis, Padilha Ana, Yuan Wei, Seed George, Bogdan Denisa, Gurel Bora, Bertan Claudia, Miranda Susana, Lambros Maryou, Montero-Hidalgo Antonio J, Coleman Ilsa, Yu Ivan Pak Lok, Buroni Lorenzo, Zeng Wanting, Neeb Antje J, Welti Jon, Rekowski Jan, Paravati Roberta, Gabel Florian, Pandell Nicole, Ferreira Ana, Crespo Mateus, Riisnaes Ruth, Das Souvik, Taylor Joe, Waldron Nick, Hobern Emily, Valenti Melanie, Ning Jian, Bernett Ilona, Liodaki Kate, Persse Thomas, Galipeau Patricia, Wilkinson Scott, Trostel Shana Y, Karzai Fatima, Chau Cindy H, Beatson Erica L, Zhang Xiaohu, Klumpp-Thomas Carleen, Varkaris Andreas, Luque Raul M, Swain Amanda, Raynaud Florence, Lack Nathan A, Thomas Craig J, Ha Gavin, Figg William D, Bezzi Marco, Sowalsky Adam G, Nelson Peter S, Carreira Suzanne, Balk Steven P, de Bono Johann S, Sharp Adam

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.

在具有 TMPRSS2:ERG 融合的前列腺癌中,雄激素剥夺介导的 AKT 激活增强。

Ma Fen, Chen Sen, Cecchi Luigi, Ersoy-Fazlioglu Betul, Russo Joshua W, Arai Seiji, Awad Seifeldin, Calagua Carla, Xie Fang, Poluben Larysa, Voznesensky Olga, Ku Anson T, Karzai Fatima, Cai Changmeng, Einstein David J, Ye Huihui, Yuan Xin, Toker Alex, Taplin Mary-Ellen, Sowalsky Adam G, Balk Steven P

Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer.

急性 BRCA 诱导和通过 CDK12/7/9 降解阻断 AR 通路可增强前列腺癌对 PARP 抑制剂的敏感性

Gui Fu, Jiang Baishan, Jiang Jie, He Zhixiang, Tsujino Takuya, Takai Tomoaki, Arai Seiji, Pana Celine, Köllermann Jens, Bradshaw Gary Andrew, Eisert Robyn, Kalocsay Marian, Fassl Anne, Balk Steven P, Kibel Adam S, Jia Li

BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways.

BCL2 通过协调致癌通路之间的相互串扰,驱动去势敏感性前列腺癌产生去势抵抗

Hirani Rahim, Nandakumar Subhiksha, Zaman Nabila, Prabhakaraalva Prathiksha, King Sarah Ann, Kalidindi Teja Muralidhar, Ghale Romina, Rajanala Sai Harisha, Fidele Deborah C, De Stanchina Elisa, Mary Lee Gwo-Shu, Taplin Mary Ellen, Balk Steven P, Sowalsky Adam G, Morris Michael J, Kishore Pillarsetty Naga Vara, Stopsack Konrad H, Gopalan Anuradha, Mucci Lorelei A, Kyprianou Natasha, Tewari Ashutosh K, Danila Daniel, Kantoff Philip W, Chakraborty Goutam

Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells.

去势抵抗性前列腺癌肿瘤中 Rb 功能正常和 Rb 缺陷细胞混合存在时,对高剂量睾酮的反应存在异质性

Labaf Maryam, Han Wanting, Zhang Songqi, Liu Mingyu, Patten Nolan D, Li Muqing, Patalano Susan, Macoska Jill A, Balk Steven P, Han Dong, Zarringhalam Kourosh, Cai Changmeng

RNAs anchoring replication complex control initiation and firing of DNA replication.

RNA锚定复制复合物控制DNA复制的起始和进行

Ummarino Simone, Poluben Larysa, Ebralidze Alex K, Autiero Ida, Zhang Yanzhou, Paniza Theodore, Deshpande Madhura, Rinaldi Lucrezia, Lee Johnathan D, Bassal Mahmoud A, Trinh Bon Q, Balk Steven P, Flaumenhaft Robert, Gerhardt Jeannine, Mirkin Sergei M, Tenen Daniel G, Di Ruscio Annalisa