日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug

利用NQO1激活前药选择性靶向NRF2高表达的胰腺导管腺癌

Antonucci, Laura; Watari, Kosuke; Feng, Yechen; Qi, Jingjing; Zhu, Mandy; Wang, Tingya; Ng, Isabella; Vucic, Emily A; Riahi, Irene; Huang, Li; Hosseini, Mojgan; Mose, Evangeline; French, Randall; Weitz, Jonathan; Bar-Sagi, Dafna; Dawson, David W; Sun, Beicheng; Tiriac, Herve; Xu, Jinyi; Xu, Shengtao; Lowy, Andrew M; Karin, Michael

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

自我扩增的 NRF2-EZH2 表观遗传环将 KRAS 启动的祖细胞转化为侵袭性胰腺癌

Antonucci Laura, Li Na, Duran Angeles, Cobo Isidoro, Nicoletti Chiara, Watari Kosuke, Nandi Shuvro Prokash, Zhu Feng, Zhao Yongmei, Riahi Irene, Tsuda Motoyuki, Shah Vidhi M, Morgan Terry, Waugh Trent, Caputo Luca, Liu Yuan, Rundberg Nilsson Alexandra, Xian Hongxu, Todoric Jelena, Gu Li, Sanchez-Lopez Elsa, Eibl Guido, Vucic Emily A, Krawczyk Michal, Xu Qianlan, Lowy Andrew M, Hatzivassiliou Georgia, Roose-Girma Merone, Skowronska-Krawczyk Dorota, Scott David A, Bar-Sagi Dafna, Tamayo Pablo, Wu Ying, Sears Rosalie C, Glass Christopher K, Alexandrov Ludmil B, Puri Pier Lorenzo, Dawson David W, Hu Yinling, Diaz-Meco Maria T, Moscat Jorge, Karin Michael

Embracing cancer complexity: Hallmarks of systemic disease

拥抱癌症的复杂性:系统性疾病的标志

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

CD73依赖性腺苷信号通过Adora2b驱动导管胰腺癌的免疫抑制

Erika Y Faraoni # ,Kanchan Singh # ,Vidhi Chandra ,Olivereen Le Roux ,Yulin Dai ,Ismet Sahin ,Baylee J O'Brien ,Lincoln N Strickland ,Le Li ,Emily Vucic ,Amanda N Warner ,Melissa Pruski ,Trent Clark ,George Van Buren ,Nirav C Thosani ,John S Bynon ,Curtis J Wray ,Dafna Bar-Sagi ,Kyle L Poulsen ,Lana A Vornik ,Michelle I Savage ,Shizuko Sei ,Altaf Mohammed ,Zhongming Zhao ,Powel H Brown ,Tingting Mills ,Holger K Eltzschig ,Florencia McAllister ,Jennifer M Bailey-Lundberg

A Multivalent Peptoid Conjugate Modulates Androgen Receptor Transcriptional Activity to Inhibit Therapy-resistant Prostate Cancer

多价肽缀合物通过调节雄激素受体转录活性抑制耐药性前列腺癌

Justine Habault ,Jeffrey A Schneider ,Susan Ha ,Rachel Ruoff ,Luiza D Pereira ,Joseph Puccini ,Michela Ranieri ,Ruveyda Ayasun ,Jiehui Deng ,Amanda C Kasper ,Dafna Bar-Sagi ,Kwok-Kin Wong ,Amina Zoubeidi ,Frank Claessens ,David R Wise ,Susan K Logan ,Kent Kirshenbaum ,Michael J Garabedian

Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis

ATP柠檬酸裂解酶的细胞骨架结合控制大胞饮作用的机械动力学

Joseph Puccini, Jia Wei, Liang Tong, Dafna Bar-Sagi

Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer

运动诱导的IL-15/IL-15Rα轴激活可促进胰腺癌的抗肿瘤免疫。

Emma Kurz ,Carolina Alcantara Hirsch ,Tanner Dalton ,Sorin Alberto Shadaloey ,Alireza Khodadadi-Jamayran ,George Miller ,Sumedha Pareek ,Hajar Rajaei ,Chirayu Mohindroo ,Seyda Baydogan ,An Ngo-Huang ,Nathan Parker ,Matthew H G Katz ,Maria Petzel ,Emily Vucic ,Florencia McAllister ,Keri Schadler ,Rafael Winograd ,Dafna Bar-Sagi

EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

EMSY 抑制同源重组修复和干扰素反应,促进肺癌免疫逃避

Antonio Marzio, Emma Kurz, Jennifer M Sahni, Giuseppe Di Feo, Joseph Puccini, Shaowen Jiang, Carolina Alcantara Hirsch, Arnaldo A Arbini, Warren L Wu, Harvey I Pass, Dafna Bar-Sagi, Thales Papagiannakopoulos, Michele Pagano

MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis

MACHETE 发现干扰素包含的 9p21.3 染色体缺失是免疫逃避和转移的介质

Francisco M Barriga #, Kaloyan M Tsanov #, Yu-Jui Ho, Noor Sohail, Amy Zhang, Timour Baslan, Alexandra N Wuest, Isabella Del Priore, Brigita Meškauskaitė, Geulah Livshits, Direna Alonso-Curbelo, Janelle Simon, Almudena Chaves-Perez, Dafna Bar-Sagi, Christine A Iacobuzio-Donahue, Faiyaz Notta, Ronan

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

在缺氧条件下,巨胞饮作用的适应性刺激可克服癌细胞中天冬氨酸的限制。

Garcia-Bermudez, Javier; Badgley, Michael A; Prasad, Sheela; Baudrier, Lou; Liu, Yuyang; La, Konnor; Soula, Mariluz; Williams, Robert T; Yamaguchi, Norihiro; Hwang, Rosa F; Taylor, Laura J; de Stanchina, Elisa; Rostandy, Bety; Alwaseem, Hanan; Molina, Henrik; Bar-Sagi, Dafna; Birsoy, Kıvanç