日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug

利用NQO1激活前药选择性靶向NRF2高表达的胰腺导管腺癌

Antonucci, Laura; Watari, Kosuke; Feng, Yechen; Qi, Jingjing; Zhu, Mandy; Wang, Tingya; Ng, Isabella; Vucic, Emily A; Riahi, Irene; Huang, Li; Hosseini, Mojgan; Mose, Evangeline; French, Randall; Weitz, Jonathan; Bar-Sagi, Dafna; Dawson, David W; Sun, Beicheng; Tiriac, Herve; Xu, Jinyi; Xu, Shengtao; Lowy, Andrew M; Karin, Michael

Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

自我扩增的 NRF2-EZH2 表观遗传环将 KRAS 启动的祖细胞转化为侵袭性胰腺癌

Antonucci Laura, Li Na, Duran Angeles, Cobo Isidoro, Nicoletti Chiara, Watari Kosuke, Nandi Shuvro Prokash, Zhu Feng, Zhao Yongmei, Riahi Irene, Tsuda Motoyuki, Shah Vidhi M, Morgan Terry, Waugh Trent, Caputo Luca, Liu Yuan, Rundberg Nilsson Alexandra, Xian Hongxu, Todoric Jelena, Gu Li, Sanchez-Lopez Elsa, Eibl Guido, Vucic Emily A, Krawczyk Michal, Xu Qianlan, Lowy Andrew M, Hatzivassiliou Georgia, Roose-Girma Merone, Skowronska-Krawczyk Dorota, Scott David A, Bar-Sagi Dafna, Tamayo Pablo, Wu Ying, Sears Rosalie C, Glass Christopher K, Alexandrov Ludmil B, Puri Pier Lorenzo, Dawson David W, Hu Yinling, Diaz-Meco Maria T, Moscat Jorge, Karin Michael

Embracing cancer complexity: Hallmarks of systemic disease

拥抱癌症的复杂性:系统性疾病的标志

Swanton, Charles; Bernard, Elsa; Abbosh, Chris; André, Fabrice; Auwerx, Johan; Balmain, Allan; Bar-Sagi, Dafna; Bernards, René; Bullman, Susan; DeGregori, James; Elliott, Catherine; Erez, Ayelet; Evan, Gerard; Febbraio, Mark A; Hidalgo, Andrés; Jamal-Hanjani, Mariam; Joyce, Johanna A; Kaiser, Matthew; Lamia, Katja; Locasale, Jason W; Loi, Sherene; Malanchi, Ilaria; Merad, Miriam; Musgrave, Kathryn; Patel, Ketan J; Quezada, Sergio; Wargo, Jennifer A; Weeraratna, Ashani; White, Eileen; Winkler, Frank; Wood, John N; Vousden, Karen H; Hanahan, Douglas

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

在缺氧条件下,巨胞饮作用的适应性刺激可克服癌细胞中天冬氨酸的限制。

Garcia-Bermudez, Javier; Badgley, Michael A; Prasad, Sheela; Baudrier, Lou; Liu, Yuyang; La, Konnor; Soula, Mariluz; Williams, Robert T; Yamaguchi, Norihiro; Hwang, Rosa F; Taylor, Laura J; de Stanchina, Elisa; Rostandy, Bety; Alwaseem, Hanan; Molina, Henrik; Bar-Sagi, Dafna; Birsoy, Kıvanç

Exploiting cancer's drinking problem: regulation and therapeutic potential of macropinocytosis

利用癌症患者的“饮水问题”:巨胞饮作用的调控及其治疗潜力

Puccini, Joseph; Badgley, Michael Alexander; Bar-Sagi, Dafna

A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment

胰腺癌联合免疫疗法的新靶点:IL-1β介导肿瘤微环境中的免疫抑制

Winograd, Rafael; Simeone, Diane M; Bar-Sagi, Dafna

Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells

巨胞饮作用是癌细胞摄取肽模拟物的关键决定因素

Yoo, Daniel Y; Barros, Stephanie A; Brown, Gordon C; Rabot, Christian; Bar-Sagi, Dafna; Arora, Paramjit S

Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics

利用合理设计的肽模拟物对 Ras G12C 进行共价靶向

Yoo, Daniel Y; Hauser, Andrew D; Joy, Stephen T; Bar-Sagi, Dafna; Arora, Paramjit S

ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis

ATDC是KRAS诱导的胰腺肿瘤发生的必要条件。

Wang, Lidong; Yang, Huibin; Zamperone, Andrea; Diolaiti, Daniel; Palmbos, Phillip L; Abel, Ethan V; Purohit, Vinee; Dolgalev, Igor; Rhim, Andrew D; Ljungman, Mats; Hadju, Christina H; Halbrook, Christopher J; Bar-Sagi, Dafna; di Magliano, Marina Pasca; Crawford, Howard C; Simeone, Diane M

Kras and Tumor Immunity: Friend or Foe?

Kras与肿瘤免疫:敌友难辨?

Cullis, Jane; Das, Shipra; Bar-Sagi, Dafna