日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designing allosteric modulators to change GPCR G protein subtype selectivity

设计变构调节剂以改变GPCR G蛋白亚型选择性

Moore, Madelyn N; Person, Kelsey L; Robleto, Valeria L; Alwin, Abigail R; Krusemark, Campbell L; Foster, Noah; Ray, Caroline; Inoue, Asuka; Jackson, Michael R; Sheedlo, Michael J; Barak, Lawrence S; Marron Fernandez de Velasco, Ezequiel; Olson, Steven H; Slosky, Lauren M

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.

神经降压素受体 1 的 Arrestin 偏向性变构调节剂可缓解急性和慢性疼痛

Guo Ran, Chen Ouyang, Zhou Yang, Bang Sangsu, Chandra Sharat, Li Yize, Chen Gang, Xie Rou-Gang, He Wei, Xu Jing, Zhou Richard, Song Shaoyong, Person Kelsey L, Moore Madelyn N, Alwin Abigail R, Spasojevic Ivan, Jackson Michael R, Olson Steven H, Caron Marc G, Slosky Lauren M, Wetsel William C, Barak Lawrence S, Ji Ru-Rong

Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators

利用虚拟化合物筛选发现多巴胺D1受体偏向性变构调节剂

Zhou, Yang; Wetsel, William C; Olson, Steven H; Barak, Lawrence S

Nonlinear progression during the occult transition establishes cancer lethality.

隐匿性转变期间的非线性进展导致癌症致命性

Ginzel Joshua D, Chapman Henry, Sills Joelle E, Allen Edwin J, Barak Lawrence S, Cardiff Robert D, Borowsky Alexander D, Lyerly Herbert Kim, Rogers Bruce W, Snyder Joshua C

Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents

神经降压素受体1的偏向性变构调节剂可降低啮齿动物的乙醇摄入量和对乙醇给药的反应

Gereau, Graydon B; Zhou, Diana; Voorhies, Kalynn Van; Tyler, Ryan E; Campbell, Jeffrey; Murray, Jackson G; Alvarez-Pamir, Ali; Wykoff, Luke A; Companion, Michel A; Jackson, Michael R; Olson, Steven H; Barak, Lawrence S; Slosky, Lauren M; Vetreno, Ryan P; Besheer, Joyce; McElligott, Zoe A

β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

β-arrestin偏向性神经降压素受体1变构调节剂可降低啮齿动物的乙醇摄入量和对乙醇给药的反应

Gereau, Graydon B; Zhou, Diana; Van Voorhies, Kalynn; Tyler, Ryan E; Campbell, Jeffrey; Murray, Jackson G; Alvarez-Pamir, Ali; Wykoff, Luke A; Companion, Michel A; Jackson, Michael R; Olson, Steven H; Barak, Lawrence S; Slosky, Lauren M; Vetreno, Ryan P; Besheer, Joyce; McElligott, Zoe A

Nonlinear progression during the occult transition establishes cancer lethality

隐匿性转变期间的非线性进展导致癌症致命性

Ginzel, Joshua D; Chapman, Henry; Sills, Joelle E; Allen, Edwin J; Barak, Lawrence S; Cardiff, Robert D; Borowsky, Alexander D; Lyerly, H Kim; Rogers, Bruce W; Snyder, Joshua C

Ghrelin receptor signaling in health and disease: a biased view

胃饥饿素受体信号传导在健康和疾病中的作用:一种有偏见的观点

Gross, Joshua D; Zhou, Yang; Barak, Lawrence S; Caron, Marc G

Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens

神经降压素受体1偏向性配体减弱神经降压素介导的腹侧被盖区多巴胺神经元的兴奋以及伏隔核中的多巴胺释放

Singhal, Sarthak M; Zell, Vivien; Faget, Lauren; Slosky, Lauren M; Barak, Lawrence S; Caron, Marc G; Pinkerton, Anthony B; Hnasko, Thomas S

Establishment of multi-stage intravenous self-administration paradigms in mice

建立小鼠多阶段静脉注射自我给药模型

Slosky, Lauren M; Pires, Andrea; Bai, Yushi; Clark, Nicholas B; Hauser, Elizabeth R; Gross, Joshua D; Porkka, Fiona; Zhou, Yang; Chen, Xiaoxiao; Pogorelov, Vladimir M; Toth, Krisztian; Wetsel, William C; Barak, Lawrence S; Caron, Marc G