日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的耐药性是由可靶向的TGFβ衰老分泌组驱动的。

González-Gualda, Estela; Reinius, Marika A V; Macias, David; Morsli, Samir; Ge, Jianfeng; Olan, Ioana; Martín, José Ezequiel; Ou, Hui-Ling; Hartono, Muhamad; Puerto-Camacho, María Pilar; Denholm, Mary; Kieran, Rosalind; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Jimenez-Linan, Mercedes; Fruk, Ljiljana; Martins, Carla P; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E; Rassl, Doris M; Doherty, Gary J; Rintoul, Robert C; Narita, Masashi; Brenton, James D; Muñoz-Espín, Daniel

RAF1 as a standalone therapeutic target in KRAS-driven lung adenocarcinoma: No added efficacy from co-targeting ARAF, EGFR, or DDR1

RAF1 作为 KRAS 驱动的肺腺癌的独立治疗靶点:联合靶向 ARAF、EGFR 或 DDR1 并无额外疗效

de-la-Puente-Ovejero, Laura; Fernández-Rodríguez, Ana; Francoz, Sarah; Aizpurua, Gonzalo; Lomba-Riego, Lucía; Drosten, Matthias; Guerra, Carmen; Musteanu, Mónica; Barbacid, Mariano; García-Alonso, Sara

Cell cycle duration determines oncogenic transformation capacity.

细胞周期持续时间决定了其致癌转化能力

Chen Danian, Lu Suying, Huang Katherine, Pearson Joel D, Pacal Marek, Peidis Phillipos, McCurdy Sean, Yu Tao, Sangwan Monika, Nguyen Angela, Monnier Philippe P, Schramek Daniel, Zhu Liang, Santamaria David, Barbacid Mariano, Akeno Nagako, Wikenheiser-Brokamp Kathryn A, Bremner Rod

A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance.

靶向联合疗法可有效抑制胰腺癌并防止肿瘤产生耐药性。

Liaki Vasiliki, Barrambana Sara, Kostopoulou Myrto, Lechuga Carmen G, Zamorano-Dominguez Elena, Acosta Domingo, Morales-Cacho Lucia, Álvarez Ruth, Sun Pian, Rosas-Perez Blanca, Barrero Rebeca, Jiménez-Parrado Silvia, López-García Alejandra, San Roman Marta, López-Gil Juan Carlos, Drosten Matthias, Sainz Bruno Jr, Musteanu Monica, Caleiras Eduardo, Dusetti Nelson, Poli Valeria, Sánchez-Bueno Francisco, Guerra Carmen, Barbacid Mariano

Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice.

系统性 Kras 消融会破坏成年小鼠的髓系细胞稳态

Zamorano-Dominguez Elena, Morales-Cacho Lucía, Barrero Rebeca, Jiménez-Parrado Silvia, Dhawahir Alma, Hernández-Porras Isabel, Simón-Carrasco Lucía, Barrambana Sara, Sun Pian, Galván-Del-Rey Ana, Rosas-Perez Blanca, Liaki Vasiliki, Drosten Matthias, Musteanu Mónica, Virga Federico, Santos Eugenio, Mulero Francisca, Caleiras Eduardo, Guerra Carmen, Barbacid Mariano

The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations

抑制因子Capicua是Kras/Trp53突变驱动的肺肿瘤发展的屏障。

Irene Ballesteros-González ,Iván Hernández-Navas ,Oksana Brehey ,Carmen G Lechuga ,Marina Salmón ,Morena Scotece ,Ricardo Velasco-Vicente ,Alejandra A Flores-Gómez ,Antonio Cebriá ,Lucía Simón-Carrasco ,Gerardo Jiménez ,Monica Musteanu ,Carmen Guerra ,Orlando Domínguez ,Eduardo Caleiras ,Carmen Blanco-Aparicio ,Tirso Pons ,Irene Ferrer ,Luis Paz-Ares ,Raul Torres-Ruiz ,Sandra Rodríguez-Perales ,Mariano Barbacid ,Matthias Drosten

Different Ras isoforms regulate synaptic plasticity in opposite directions.

不同的Ras亚型以相反的方向调节突触可塑性

López-Merino Esperanza, Fernández-Rodrigo Alba, Jiang Jessie G, Gutiérrez-Eisman Silvia, Fernández de Sevilla David, Fernández-Medarde Alberto, Santos Eugenio, Guerra Carmen, Barbacid Mariano, Esteban José A, Briz Víctor

Interleukin-11 promotes lung adenocarcinoma tumourigenesis and immune evasion

白细胞介素-11促进肺腺癌的肿瘤发生和免疫逃逸

Cristina Cirauqui ,Laura Ojeda ,Itziar Otano ,Irene Pazos ,Alba Santos ,Eva M Garrido-Martín ,Patricia Yagüe ,Javier Ramos-Paradas ,Sonia Molina-Pinelo ,Giovanna Roncador ,José Luis Solórzano ,M Teresa Muñoz ,Patricia Cozar ,Patricia Plaza ,Rocío Suárez ,Marta Jiménez ,Roberto Moreno ,Arantxa Rosado ,Pablo Gámez ,Ricardo García-Luján ,Jon Zugazagoitia ,E Alejandro Sweet-Cordero ,Mariano Barbacid ,Amancio Carnero ,Irene Ferrer ,Luis Paz-Ares

Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins.

活性 R-RAS2/TC21 可防止缺乏 RAS 蛋白的小鼠胚胎成纤维细胞发生细胞周期停滞和形态改变

Fernández-Pisonero Isabel, Lorenzo-Martín L Francisco, Drosten Mattias, Santos Eugenio, Barbacid Mariano, Alarcón Balbino, Bustelo Xosé R

T Cell-Specific Inactivation of the PI3K p110α Catalytic Subunit: Effect in T Cell Differentiation and Antigen-Specific Responses

T细胞特异性PI3K p110α催化亚基失活:对T细胞分化和抗原特异性反应的影响

Briones, Alejandro C; Del Estal, Laura; Villa-Gómez, Cristina; Bermejo, Verónica; Cervera, Isabel; Gutiérrez-Huerta, Pedro; Montes-Casado, María; Ortega, Sagrario; Barbacid, Mariano; Rojo, José María; Portolés, Pilar