Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region
淀粉样蛋白前体 (APP) 的赖氨酸 624 是淀粉样蛋白 β 肽长度的关键决定因素:支持 γ-分泌酶膜内蛋白水解的顺序模型以及淀粉样蛋白 β 前体 (APP) 近膜区的调节
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M111.274696
Thomas L Kukar, Thomas B Ladd, Paul Robertson, Sean A Pintchovski, Brenda Moore, Maralyssa A Bann, Zhao Ren, Karen Jansen-West, Kim Malphrus, Simone Eggert, Hiroko Maruyama, Barbara A Cottrell, Pritam Das, Guriqbal S Basi, Edward H Koo, Todd E Golde