日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

γ-分泌酶调节剂和 APH1 同工型调节 γ-分泌酶裂解但不调节淀粉样前体蛋白 (APP) ε-裂解的位置

Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo

Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region

淀粉样蛋白前体 (APP) 的赖氨酸 624 是淀粉样蛋白 β 肽长度的关键决定因素:支持 γ-分泌酶膜内蛋白水解的顺序模型以及淀粉样蛋白 β 前体 (APP) 近膜区的调节

Thomas L Kukar, Thomas B Ladd, Paul Robertson, Sean A Pintchovski, Brenda Moore, Maralyssa A Bann, Zhao Ren, Karen Jansen-West, Kim Malphrus, Simone Eggert, Hiroko Maruyama, Barbara A Cottrell, Pritam Das, Guriqbal S Basi, Edward H Koo, Todd E Golde