日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

通过共价双亚基抑制疟原虫蛋白酶体降低抗疟药耐药性风险

Ioanna Deni, Barbara H Stokes, Kurt E Ward, Kate J Fairhurst, Charisse Flerida A Pasaje, Tomas Yeo, Shirin Akbar, Heekuk Park, Ryan Muir, Daniella S Bick, Wenhu Zhan, Hao Zhang, Yi Jing Liu, Caroline L Ng, Laura A Kirkman, Jehad Almaliti, Alexandra E Gould, Maëlle Duffey, Anthony J O'Donoghue, Anne-

A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin

恶性疟原虫 Na+ 泵 PfATP4 中的 G358S 突变导致对西帕加明产生临床相关的耐药性

Deyun Qiu #, Jinxin V Pei #, James E O Rosling #, Vandana Thathy, Dongdi Li, Yi Xue, John D Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K Tripathi, Nina F Gnadig, Tomas Yeo, Kate J Fairhurst, Barbara H Stokes, James M Murithi, Krittikorn Kümpornsin, Hea

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival

青蒿素抗性 K13 突变重新连接恶性疟原虫的红细胞内代谢程序以提高存活率

Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech #, Andrew B Tobin #, David A Fidock

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

非洲和亚洲的恶性疟原虫K13突变影响青蒿素耐药性和寄生虫适应性

Barbara H Stokes,Satish K Dhingra,Kelly Rubiano,Sachel Mok,Judith Straimer,Nina F Gnädig,Ioanna Deni,Kyra A Schindler,Jade R Bath,Kurt E Ward,Josefine Striepen,Tomas Yeo,Leila S Ross,Eric Legrand,Frédéric Ariey,Clark H Cunningham,Issa M Souleymane,Adama Gansané,Romaric Nzoumbou-Boko,Claudette Ndayikunda,Abdunoor M Kabanywanyi,Aline Uwimana,Samuel J Smith,Olimatou Kolley,Mathieu Ndounga,Marian Warsame,Rithea Leang,François Nosten,Timothy Jc Anderson,Philip J Rosenthal,Didier Ménard,David A Fidock

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

抗疟天然产物Salinipostin A 可鉴定恶性疟原虫脂质代谢中必需的α/β丝氨酸水解酶

Euna Yoo ,Christopher J Schulze ,Barbara H Stokes ,Ouma Onguka ,Tomas Yeo ,Sachel Mok ,Nina F Gnädig ,Yani Zhou ,Kenji Kurita ,Ian T Foe ,Stephanie M Terrell ,Michael J Boucher ,Piotr Cieplak ,Krittikorn Kumpornsin ,Marcus C S Lee ,Roger G Linington ,Jonathan Z Long ,Anne-Catrin Uhlemann ,Eranthie Weerapana ,David A Fidock ,Matthew Bogyo

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

深入了解恶性疟原虫 K13 的细胞内定位、蛋白质关联和青蒿素抗性特性

Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock